9,952 research outputs found
Population differentiation and gene flow revealed by microsatellite DNA markers in the house mouse (Mus musculus castaneus) in Taiwan.
No full textThe protein conformation and a zinc-binding domain of an autoantigen from mouse seminal vesicle.
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Joint optimization of transmit power and operating point of channel sensing for cognitive radio networks
No full textThe ecology of parental care in an arboreal breeding frog, Chirixalus eiffingeri (Anura: Rhacophoridae) from Taiwan.
No full textRegenerative third-harmonic frequency modulated(FM) mode-locking in a bulk Nd : YLF laser
No full textWe have demonstrated a regenerative harmonic frequency modulated(FM) mode-locking in a bulk Nd:LiYF4 (YLF) laser for the first time. After suppressing the mode competition between positive (up-chirped) and negative (down-chirped) modes using an etalon, a third-harmonic FM mode-locking based on a regenerative feedback loop was realized in a Nd:YLF laser. Stable, self-starting pulses were generated with a duration of 6.5 ps at 1-GHz repetition rate and an average output power of 240 mW at a 1-W laser diode pumping power.This work is supported by the Minstry of Science and Technology of Korea Through the Creative Research Initiative Program
A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity
No full textAbstractProtein kinase B (PknB) is one of the Mycobacterium tuberculosis serine/threonine protein kinases and has an essential role in sustaining mycobacterial growth. Here, we identified and characterized a novel small molecule compound named IMB-YH-8 that inhibited PknB and served as anti-mycobacteria lead compound. IMB-YH-8 inhibited PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner. The compound did not inhibit human Akt1 or other serine/threonine kinases in M. tuberculosis except for the highly homologous PknA. IMB-YH-8 bound to PknB with a moderate affinity. Molecular docking revealed that IMB-YH-8 interacts with the catalytic domain of PknB. Observations of electron microscopy showed that IMB-YH-8 changed the morphology of H37Rv and disrupted the cell wall. The differential transcriptional response of M. tuberculosis to IMB-YH-8 revealed changes in SigH regulatory pathways modulated by PknB. Notably IMB-YH-8 not only potently inhibited drug-sensitive and multidrug-resistant clinical isolates but also exhibited a dose dependent inhibition of intracellular M. tuberculosis. Taken together, these in vitro data demonstrate that IMB-YH-8 is a novel inhibitor of PknB, which potently prevents growth of M. tuberculosis. It is as yet unclear whether inhibition of PknA contributes to the anti-tubercular action of IMB-YH-8.</jats:p
Correlation of a missense mutation in the human Secretor alpha-1, 2-fucosyl-transferase gene with the Lewis (a+b+) phenotype: a potential molecular-basis for the weak Secretor allele (Se-w).
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