56 research outputs found
Organocatalytic asymmetric Michael reaction with acylsilane donors
No full textWe have developed an organocatalytic asymmetric Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane alpha-alkylation with a chiral guanidine catalyst, which afforded products in good yields and high stereoselectivity. The corresponding adducts described here have also been demonstrated to be useful in the synthesis of unnatural amino acids and biologically active compounds
ChemInform Abstract: New Convenient Synthesis of 6‐Fluoropurine and Its 7‐/9‐Unsubstituted Analogues.
No full textChemInform Abstract: Organocatalytic Asymmetric Michael Reaction with Acylsilane Donors.
No full textPractical Synthesis of (‐)‐α‐Aminobenzolactam via Nitration‐Cyclization of L‐Homophenylalanine Ethyl Ester.
No full textA Modular Approach to Dibenzo‐fused ϵ‐Lactams: Palladium‐Catalyzed Bridging‐C−H Activation
No full textSelective and efficient synthesis of trans-arylvinylboronates and trans-hetarylvinylboronates using palladium catalyzed cross-coupling
No full textA versatile method of palladium catalyzed cross-coupling between pinacol vinylboronate and (het)arylbromides to obtain trans-(het)arylvinylboronates in excellent yields and selectivity.</p
Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)-N-methylpicolinamide Derivatives as Potential Antitumor Agents
No full textA novel series of 4-(4-formamidophenylamino)-N-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT116) at low micromolar concentrations and the most potent analog 5q possessed broad-spectrum antiproliferative activity. Experiments in vivo demonstrated that 5q could effectively prolong the longevity of colon carcinoma-burdened mice and slow down the progression of cancer cells by suppression of angiogenesis and the induction of apoptosis and necrosis
Construction of Protoberberine Alkaloid Core through Palladium Carbene Bridging CH Bond Functionalization and Pyridine Dearomatization
No full textVisible Light Enabled Formal Cross Silyl Benzoin Reaction as an Access to α‐Hydroxyketones
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