2,605 research outputs found
Supplemental Material, Supplementary_figures - Low-Density Lipoprotein Receptor-Related Protein 6 Is Essential for Trophoblast Survival and Invasion
No full textSupplemental Material, Supplementary_figures for Low-Density Lipoprotein Receptor-Related Protein 6 Is Essential for Trophoblast Survival and Invasion by Lei Li, Jipeng Wan, Jing Xue, Hongyan Li, Shan Wang, Qian Zhou, Yu Zhou, and Xietong Wang in Reproductive Sciences</p
sj-pdf-1-pic-10.1177_09544062211026352 - Supplemental material for Contact characteristics of steel-rubber rollers based on modified contact theory considering viscoelasticity
No full textSupplemental material, sj-pdf-1-pic-10.1177_09544062211026352 for Contact characteristics of steel-rubber rollers based on modified contact theory considering viscoelasticity by Hongyan Chu, Qiang Yu, Caixia Zhang, Qi Chen, Ruilong Ding and Yingjie Hong in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science</p
Corrigendum to “Porosity estimation in kerogen-bearing shale gas reservoirs” [J. Nat. Gas Sci. Eng. 52 (2018) 575–581]
No full textThe authors regret that the Fig. 3 was uploaded wrong by mistake. Refers to: Hongyan Yu, Zhenliang Wang, Reza Rezaee, Yihuai Zhang, Tongcheng Han, Muhammad Arif, Lukman Johnson. Porosity estimation in kerogen-bearing shale gas reservoirs. Journal of Natural Gas Science and Engineering, Volume 52, April 2018, Pages 575-581
Extreme rainfall and snowfall alter responses of soil respiration to nitrogen fertilization : a 3-year field experiment
No full textAuthor Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Global Change Biology 23 (2017): 3403-3417, doi:10.1111/gcb.13620.Extreme precipitation is predicted to be more frequent and intense accompanying global
warming, and may have profound impacts on soil respiration (Rs) and its components, i.e.,
autotrophic (Ra) and heterotrophic (Rh) respiration. However, how natural extreme rainfall or
snowfall events affect these fluxes are still lacking, especially under nitrogen (N) fertilization.
In this study, extreme rainfall and snowfall events occurred during a 3-year field experiment,
allowing us to examine their effects on the response of Rs, Rh and Ra to N supply. In normal
rainfall years of 2011/2012 and 2012/2013, N fertilization significantly stimulated Rs by 23.9%
and 10.9%, respectively. This stimulation was mainly due to the increase of Ra because of
N-induced increase in plant biomass. In the record wet year of 2013/2014, however, Rs was
independent on N supply because of the inhibition effect of the extreme rainfall event.
Compared with those in other years, Rh and Ra were reduced by 36.8% and 59.1%,
respectively, which were likely related to the anoxic stress on soil microbes and decreased
photosynthates supply. Although N supply did not affect annual Rh, the response ratio (RR) of
Rh flux to N fertilization decreased firstly during growing season, increased in nongrowing
season and peaked during spring thaw in each year. Nongrowing season Rs and Rh
contributed 5.5–16.4% to their annual fluxes, and were higher in 2012/2013 than other years
due to the extreme snowfall inducing higher soil moisture during spring thaw. The RR of
nongrowing season Rs and Rh decreased in years with extreme snowfall or rainfall compared
to those in normal years. Overall, our results highlight the significant effects of extreme
precipitation on responses of Rs and its components to N fertilization, which should be
incorporated into models to improve the prediction of carbon-climate feedbacks.This research was funded by the Chinese Academy of Sciences (XDB15020100) and the
National Natural Science Foundation of China (31561143011).2017-12-2
Optimal Taxation of Risky Human Capital
No full textIn a model with ex-ante homogenous households, earnings risk and a general earnings function, we derive the optimal linear labor tax rate and optimal linear education subsidies. The optimal income tax trades off social insurance against incentives to work and to invest in human capital. Education subsidies are not used for social insurance, but are only targeted at off-setting the distortions of the labor tax and internalizing a fiscal externality. Both optimal education subsidies and tax rates increase if labor and education are more complementary, since education subsidies indirectly lower labor tax distortions by stimulating labor supply. Optimal education subsidies (taxes) also correct non-tax distortions arising from missing insurance markets. Education subsidies internalize a positive (negative) fiscal externality if there is underinvestment (overinvestment) in education due to risk. Education policy unambiguously allows for more social insurance if education is a risky activity. However, if education hedges against labor market risk, optimal tax rates could be lower than without education subsidies.labor taxation, human capital investment, education subsidies, idiosyncratic risk, risk properties of human capital
Beyond Control: Why Can Some Chinese Nonprofits Maintain Autonomy When Collaborating with the Government While Others Cannot?
No full textPast research assumes that in highly restrictive institutional environments such as China, nonprofits are likely to lose autonomy when collaborating with the government. We challenge this assumption by developing a multi-factor theoretical framework (resource dependency, political connections, cooperation specificity, and organizational reputation) to explain the conditions under which nonprofits would maintain autonomy. We further test this framework using a fuzzy-set qualitative comparative analysis of 20 government-nonprofit partnerships in China. Results show that all four factors combine to contribute to autonomy. The absence of cooperation specificity is necessary for high autonomy, and three configurations are identified for high and low autonomy. The findings indicate how weaker nonprofits strategically use diverse sources of inter-organizational power to gain autonomy when facing significant power imbalances, and reveals the government’s intricate and indirect control tactics, offering insights for building more effective government-nonprofit partnerships in public services delivery.This work was supported by the Ministry of Education of China Key Project of Humanities and Social Sciences (Grant numbers: 21JZD019, 2023JZDZ036 and 2023JZDZ038).Teng, Hongyan; Cheng, Yuan; Yu, Jianxing. (2025). Beyond Control: Why Can Some Chinese Nonprofits Maintain Autonomy When Collaborating with the Government While Others Cannot?. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/276648
Investigating the role of disulfidoptosis in spinal cord injury and development of a novel diagnostic model
No full textObjective: The objective of this study is to explore the role and regulatory mechanisms of disulfidoptosis in spinal cord injury (SCI) and to develop a diagnostic model based on this cell death mechanism.
Methods: The peripheral blood RNA-seq data from SCI patients sourced from dataset GSE151371 was utilized in the study. Various
analytical techniques, including di!erential gene expression analysis, immune infiltration profiling, consistency clustering, and pathway enrichment analysis, were employed to investigate the impact of disulfidoptosis. Machine learning models were also developed to aid in the diagnosis of SCI based on gene expression profiles related to disulfidoptosis.
Results: Gene expression analysis revealed significant upregulation of genes such as GYS1, PDLIM1, NDUFA11, and MYL6, and downregulation of NUBPL, LRPPRC, and CD2AP in SCI patients, with statistical significance (P < .05). Immune infiltration profiling showed a decrease in CD4+ and CD8+ T cells, contrasted by an increase in gamma delta T cells (P < .05), indicating an altered immune landscape. Furthermore, 2 distinct subgroups were identified through consistency clustering, highlighting significant di!erences in disulfidoptosisrelated gene expression. Pathway enrichment analysis revealed di!erent pathways between clusters, suggesting diverse regulatory mechanisms within SCI subtypes. The diagnostic model evaluation using random forest achieved the highest accuracy with an area under the curve (AUC) of 0.955, demonstrating its potential utility in clinical settings for SCI diagnosis.
Conclusion: Disulfidoptosis plays a significant role in the pathophysiology of SCI. This study o!ers novel insights into its molecular
mechanisms and presents a potential foundation for diagnostic modeling.
Cite this article as: Wang C, Yu L, Hongyan M. Investigating the role of disulfidoptosis in spinal cord injury and development of a novel diagnostic model. Acta Orthop Traumatol Turc., 2025;59(4):201-209
Zhi shi yu yi li zhi jian: Qi Liang shi ge yong "shi" yan jiu = The disengagement of knowledge from doctrine : a study of allusions to history in the “Qi and Liang” poetry
No full textM.Phil.The “Qi and Liang” (齊梁) is an era characterized by its unusual enthusiasm for collecting, organizing, and categorizing the received textual past. Meanwhile, it had intense awareness of the literary legacy that reached it. In this certain kind of literary ambiance, heavy use of references and allusions in poetry (especially pentasyllabic poetry), became popular in writing practice. Histories, as special utterance outside poetry, were integrated into poetic materials. This kind of change in poetic language, is not only about the expansion of poetic lexicon, and the transformation in rhetoric, but also involves the interrelationship between poetry and history, two different patterns of knowledge and thinking. Poetry was to sing forth one’s inner feelings and innate nature (yinyong qingxing, 吟詠情性), in the eyes of its contemporaries, while, history was to be served as documents consulted for one governing the country (zhiguo wenfu, 治國文符). History has its own pre-established narrative and meaning system for interpretation. In what circumstances, could histories become poetic language? And, as material outside poetic convention, how could this particular category of knowledge, be involved into the process of arousing the poet’s feeling, and be laden with special poetic significance?When poetry is on historical themes, in the “Wei and Jin” (魏晉), both poetry and history shared the same value system and thinking pattern, which were bounded in the narrative structure of history. As for the “Qi and Liang”, they found a new way to understand history. The pre-established writing pattern, existing context and meaning system, were concealed in the Poems on History (yongshishi, 詠史詩). The wholeness of historical writing, was broken into so-called “small stories” (xishi, 細事) which were freed from the allegorical treatment of historiography. In some certain contexts, poems functioned as a way of sorting out knowledge. History becoming stories, was the special condition for it to be transformed into poetic materials. In the context of intertextual relationship between history and poetry, Yu Xin ’s (513-581) works are simultaneously conventional and original. Yu Xin’s writing was cultivated in the Southern writing practices. The use of allusions to history in his poetry, could help us to understand, how histories lurking beneath the objects, shapes the poet’s perception of them; and how objects surrounded by textual memories, become images entrusted with the poet’s life experiences and feelings. At the same time, as a survivor who experienced the fall of the Liang dynasty, Yu Xin invented a new poetic language to reminisce past historical events and personal experience, from borrowing references and allusions to history. Where did Yu Xin’s historical metaphors come from? Why did he return to the same historical events and allusions again and again? How was his voice shaped by both received knowledge and material circumstances? In the response to the questions above, it might be seen that poetic language is not isolated inside itself but circulated in the repertoire of knowledge.齊梁時，是一個熱衷於收集、整理、歸類知識的時代，對於前代文學遺產，有著高度自覺。如此學風中，大量用事，成為普遍的詩歌寫作實踐。史，作為詩歌體類之外的語言，進入詩（尤其指五言詩）中。此一新變，不只關乎詩歌語料的擴展、修辭的更新，同時蘊含了詩與史，兩種不同知識類別之間，思維的交叉與融合。詩在時人眼中，是為「吟詠情性」，而史乃「經國文符」。史，有其既定的敘述方式、義理闡釋系統。那麼，怎樣的契機下，史可以成為詩的材料？以及，史作為區別於詩的語言，如何參與詩的興感，怎樣在詩中承擔特殊表意功能？當歷史作為詩歌主題、士人吟詠對象時，魏晉詩中，詩與史共享同一價值系統，詩的思維框定於史的敘述。至於齊梁，時人以新的方式認識歷史：史的既定敘述方式及義理系統，在所謂「詠史」詩中消解，進而破碎為「細事」。「史」變為「事」，是史轉化作詩歌資源的契機。詩與史的脈絡裡，庾信的作品，既典型又特殊。滋養於南朝寫作傳統的庾信，其詩作對史事的引用，幫助我們理解，物周邊潛伏的「事」，怎樣參與詩人的感物經驗、塑造詩人眼中的物象。同時，在特殊的個人經歷與時代變革中，庾信借用史的語言，賦予詩新的主題。魏紅岩."2019年9月".Parallel title from English abstract.Thesis M.Phil. Chinese University of Hong Kong 2019.Includes bibliographical references (leaves 141-152).Abstracts in Chinese and English.Title from PDF title page (viewed on February 15, 2022).Wei Hongyan
Mussel-inspired fabrication of pH-responsive pomelo peels as “smart” bio-based adsorbents for controllable removal of both cationic and anionic dyes
No full textSupplemental Material, PTD878658_supp_mat - Estimating total small solute clearance in patients treated with continuous ambulatory peritoneal dialysis without urine and dialysate collection
No full textSupplemental Material, PTD878658_supp_mat for Estimating total small solute clearance in patients treated with continuous ambulatory peritoneal dialysis without urine and dialysate collection by Li Fan, Dominik Steubl, Lesley A Inker, Hocine Tighiouart, Andrew L Simon, Meredith C Foster, Amy B Karger, John H Eckfeldt, Hongyan Li, Jiamin Tang, Yongcheng He, Minyan Xie, Fei Xiong, Hongbo Li, Hao Zhang, Jing Hu, Yunhua Liao, Xudong Ye, Tariq Shafi, Wei Chen, Xueqing Yu and Andrew S Levey in Peritoneal Dialysis International</p
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