9 research outputs found
Human pluripotent stem cell-derived DDX4 and KRT-8 positive cells participate in ovarian follicle-like structure formation
No full textAristophanes and Euripides: A Palimpsestuous Relationship
Get PDFAristophanes allows Euripides to interrupt constantly. In Athenian comedy of the fifth century they are on stage together, both literally and figuratively. Despite Aristophanes’ comedies having a meaning of their own, Euripides’ lines are so clearly visible underneath them that they can only be described as the verbal equivalent of a palimpsest. The Oxford English Dictionary defines a palimpsest as a manuscript or piece of writing on which later writing has superimposed or effaced earlier writing, or something reused or altered but still bearing visible traces of its earlier form. It is clear that a palimpsest is the product of layering that results in something as new, whilst still bearing traces of the original. Dillon describes the palimpsest as “...an involuted phenomenon where otherwise unrelated texts are involved and entangled, intricately interwoven, interrupting and inhabiting each other”. Aristophanes takes texts, particularly those of Euripides, which may otherwise have been unrelated, and weaves them together to form something new.
I will show that in a number of cases Aristophanes offers scenes that have already been performed in Euripides’ plays but lays his own plot over the tragedian’s, whilst at the same time drawing the audiences’ attention to the original. The nature of this borrowing overwrites Kristeva’s theory of ‘intertextuality’ and provides a new and more apposite name for the permutation of texts in which the geno-text corresponds to infinite possibilities of palimpsestuous textuality (and the pheno-text to a singular text, which contains echoes of what it could have been). The plurality of Euripides’ texts, whilst engendering those of Aristophanes, constantly interrupts them. Through the consideration of ancient and modern literary theory and by a close analysis of Aristophanes’ and Euripides’ plays, this thesis sets out to offer a new reading of the relationship between these two poets. It shows that they were engaged in a dialogue of reciprocal influence that came to a head at the end of the Peloponnesian War
Why Worry About Climate Change? A Research Agenda
Get PDFEstimates of the marginal damage costs of carbon dioxide emissions suggest that, although climate change is a problem and some emission reduction is justified, very stringent abatement does not pass the cost-benefit test. However, current estimates of the economic impact of climate change are incomplete. Some of the missing impacts are likely to be positive and others negative, but overall the uncertainty seems to concentrate on the downside risks and current estimates of the damage costs may have a negative bias. The research effort on the economic impacts of climate change is minute, and should be strengthened, with a particular focus on the quantification of uncertainties; estimating missing impacts, interactions between impacts and higher-order effects; the valuation of biodiversity loss; the implications of extreme climate scenarios and violent conflict; and climate change in the very long term.Climate Change, Impacts, Valuation, Cost-benefit Analysis
Data for "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish"
No full textThis dataset contains the free arena data and imaging data for the following research paper.
Sy, S.K.H., Chan, D.C.W., Chan, R.C.H. et al. An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish. Nat Commun 14, 227 (2023). https://doi.org/10.1038/s41467-023-35836-
The British environmental movement: The development of an environmental consciousness and environmental activism, 1945-1975
No full textThis work investigates the development of an environmental consciousness and environmental activism in Britain, 1945-1975. The 1970s have been described as ‘the decade of the environment’ and was the period when the modern environmental movement emerged. In this thesis, the environmental movement is considered to be a broad network of individuals and pressure groups engaging in collective action with shared environmental beliefs. Much of the work on the movement has ignored or played down the importance of the post-war period on its development. This project challenges that, dealing less with the movement itself and more with the developments which led to its emergence: through analysing events like the great London smog of 1952 and the Torrey Canyon oil spill of 1967, as well as through television programmes, this thesis traces the post-war influences of the movement and the growth of environmental awareness.
Environmental pressure groups form part of the movement and a number of them are studied here, such as the Newcastle-based group Save Our City from Environmental Mess and the London-based group Commitment, WWF, Friends of the Earth and the National Smoke Abatement Society. From analysing the resources of these groups and the political processes within which they appear (resource mobilisation theory and political process theory) a better understanding is made about their successes, failures and how they fed into a growing environmental awareness. Television programmes from the 1950s, 1960s and 1970s – notably natural history programmes such as Look, Zoo Quest, Doctor Who and Doomwatch – also helped an environmental consciousness develop. In marrying together these different issues, this work provides an original contribution to knowledge, and assesses some of the influences which led to the environmental movement emerging in 1970s Britain
Studying the Pulmonary Endothelium in Health and Disease An Official American Thoracic Society Workshop Report
No full text388406Lung endothelium resides at the interface between the circulation and the underlying tissue, where it senses biochemical and mechanical properties of both the blood as it flows through the vascular circuit and the vessel wall. The endothelium performs the bidirectional signaling between the blood and tissue compartments that is necessary to maintain homeostasis while physically separating both, facilitating a tightly regulated exchange of water, solutes, cells, and signals. Disruption in endothelial function contributes to vascular disease, which can manifest in discrete vascular locations along the artery-to-capillary-to-vein axis. Although our understanding of mechanisms that contribute to endothelial cell injury and repair in acute and chronic vascular disease have advanced, pathophysiological mechanisms that underlie site-specific vascular disease remain incompletely understood. In an effort to improve the translatability of mechanistic studies of the endothelium, the American Thoracic Society convened a workshop to optimize rigor, reproducibility, and translation of discovery to advance our understanding of endothelial cell function in health and disease.71
Education Research Gender, Education and Development - A Partially Annotated and Selective Bibliography
Get PDFCommunity/Rural/Urban Development,
A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration
Get PDFBackground
High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ −6.00 diopters (D), is a leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk of HM and to test if a PGS is predictive of MMD after accounting for SER.
Methods
The PGS was derived from genome-wide association studies in participants of UK Biobank, CREAM Consortium, and Genetic Epidemiology Research on Adult Health and Aging. MMD severity was quantified by a deep learning algorithm. Prediction of HM was quantified as the area under the receiver operating curve (AUROC). Prediction of severe MMD was assessed by logistic regression.
Findings
In independent samples of European, African, South Asian and East Asian ancestry, the PGS explained 19% (95% confidence interval 17–21%), 2% (1–3%), 8% (7–10%) and 6% (3–9%) of the variation in SER, respectively. The AUROC for HM in these samples was 0.78 (0.75–0.81), 0.58 (0.53–0.64), 0.71 (0.69–0.74) and 0.67 (0.62–0.72), respectively. The PGS was not associated with the risk of MMD after accounting for SER: OR = 1.07 (0.92–1.24).
Interpretation
Performance of the PGS approached the level required for clinical utility in Europeans but not in other ancestries. A PGS for refractive error was not predictive of MMD risk once SER was accounted fo
