170 research outputs found
Results of recombinant growth hormone treatment in children with end-stage renal disease on regular hemodialysis
No full textChildren with chronic kidney disease are at high risk for growth retardation and decreased adult height. Growth hormone (GH) treatment is known to stimulate growth in children with short stature suffering from chronic kidney disease. However, the extent to which this the-rapy affects final adult height is not known. This study was performed on 15 patients with end-stage renal disease (ESRD) on regular hemodialysis to detect the effect of using recombinant human growth hormone (rhGH) on growth of patients with ESRD on regular hemodialysis and compa-ring this effect with the growth velocity in the same group without using rhGH in the year before therapy. There were eight females and seven males with mean age 10.6 ± 2.8 (range 5-14 years). For each patient, recombinant GH was given for one year, three-times weekly. The data of these 15 patients was compared with the year before treatment versus data of the same group of patients after six months and after one year of rhGH therapy. Our results showed that, in the year before therapy, height of these patients increased from a mean of 112.1 ± 11.6 cm to 112.7 ± 11.5 cm, which is a non-significant increase statistically (P >0.05) as well as clinically (mean growth velocity 0.6 cm/year), while height of these patients increased from a mean of 112.7 ± 11.5 cm at the start of therapy to 116.8 ± 11 cm after therapy for one year, which, although statically not significant (P >0.05), was of clinical significance as it makes rate of increase, i.e. the mean growth velocity, 4.1 cm/year close to the normal growth velocity, which is 5 cm/year, before puberty. rhGH therapy for patients with ESRD on regular hemodialysis is helpful in height gain and catch-up growth even when given three-times per week instead of five- or six-times per week. We recommend giving rhGH therapy as a routine supplementation to pediatric patients before epiphyseal closure
Value of renal resistive index as an early marker of diabetic nephropathy in children with type-1 diabetes mellitus
No full textConstant increase in the incidence of type-1 diabetes (T1-DM) has made it necessary to have new markers for the early detection of diabetic nephropathy (DN). One of the markers that could be helpful in detecting functional alterations in renal hemodynamics is assessment of the renal resistive index (RI) by using renal Doppler. We studied 25 patients with T1-DM (Group-A), which comprised of 15 females and 10 males, with a mean age of 10.8 ± 2.2 years and duration of diabetes of 5 ± 1.1 years. A control group (Group-B) comprising 20 healthy children, 12 females and eight males with mean age of 11.6 ± 2 years, was also studied. The following parameters were studied in the two groups: age, serum creatinine, albumin excretion rate (AER), glomerular filtration rate (GFR), glycosylated hemoglobin (HbA1c) and mean renal RI of both kidneys. We found an increase in the mean RI in diabetic patients versus healthy children; the mean RI in Group-A was 0.64 ± 0.55 while it was 0.58 ± 0.0.28 in Group-B (P <0.000). This increase in RI had a positive correlation with duration of the disease, GFR and HbA1c levels, but there was no correlation with serum creatinine or AER. We conclude that RI is increased early in TI-DM, and it can be a predictor of DN
Chamomile essential oil improves the growth, immunity, and antioxidant status of Nile tilapia exposed to nanosized alumina
No full textDue to their peculiar physicochemical properties, nanoparticles (NPs) have the potential to have a detrimental impact on molecular (proteins and nucleic acids), subcellular, cellular, tissue, and organism levels. However, available works on the harmful effects of the water-borne ionizable NPs, such as aluminum oxide nanoparticles (ALNPs) on fish are scarce. Therefore, the toxic impacts of ALNPs on hematological, biochemical, and immunological responses in Nile Tilapia fish were investigated in this work. Additionally, the possible benefits of the promising chamomile essential oil (CEO) as dietary supplement in alleviating such impacts were also targeted. For this, four fish groups were used. The control group received only the basic diet, CEO group (basic diet + 2 mg CEO/kg diet), ALNP group (basic diet with exposure to5.08 mg ALNPs/L water, and ALNPs/CEO group (basal diet + 2 mg CEO/kg diet + 5.08 mg ALNPs/L). Fish exposed to ALNPs showed declines in the growth performance and fish survivability in addition to changes seen in the hematological and protein profiles and stress variables. Along with decreased resistance to the Aeromonas hydrophila challenge, there were also substantial decreases in all humoral immune indicators. In addition to increased mRNA expressions of immune genes in the hepatic tissues. CEO significantly modulated the toxic effects of ALNPs suggesting its utilization as a valuable dietary supplement for fish
Pediatric systemic lupus erythematosus in a single nephrology unit
No full textClinical manifestations of systemic lupus erythematosus (SLE) are widely variable, and its course is unpredictable. SLE that begins in childhood has been considered more severe than SLE with onset during adulthood. Our aim was to determine the presentation and the outcome of SLE of 26 children (20 females and 6 males, with a female to male ratio of 3.8:1) with SLE in our center, their ages ranging from 5 - 18 years and followed from 2005 till October 2011. They were diagnosed according to the American Rheumatism Association′s revised criteria. Complete blood count, erythrocyte sedimentation rate, C3, urine analysis, 24-h urinary protein, antinuclear antibodies, anti-ds DNA and renal biopsy were obtained for the patients. We found that the most extra-renal manifestation of SLE was fever (57.7%), while lupus nephritis (LN) was the most commonly affected organ (50%). Hemolytic anemia was the most common hematological abnormality (80.8%), while immunological characteristics were positive in all the patients. Remission in patients without LN was more than 5.3-times the remission in LN patients. The outcome of the patients without LN was better than the patients with LN
Mandibular mass in a child on hemodialysis
No full textWe here with report a 13-year-old female patient on regular hemodialysis for the past five years who presented with a large mandibular mass. This was detected to be a brown tumor due to severe renal osteodystrophy as a complication of secondary hyperparathyroidism. The tumor did not regress even with intensive treatment with intravenous active vitamin D and needed surgical removal
FP797EFFECT OF HEAT KILLED PROBIOTIC AND WHEAT BRAN ON GASTROINTESTINAL SYMPTOMS IN HEMODIALYSIS CHILDREN
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1-Bit ADCヲジッソウシタタスウアンテナツウシンシステム
No full text東京農工大学Tokyo University of Agriculture and Technology博士（工学）Doctor of Philosophy (Engineering
When You are About to Diagnose Chronic Hemolytic Uremic Syndrome, Please Think More Deep
No full textAntiphospholipid syndrome is one type of immunological diseases which may be primary or secondary characterized by repeated thrombosis that it may be called “sticky blood syndrome”. Although a well-known disease in gynecology, there is no sufficient data in pediatrics field; so we see that it is important to discuss this interesting case
MP833ASSESSMENT OF THE VALUE OF URINARY KIDNEY INJURY MOLECULE-1 (UKIM -1) AS AN EARLY PREDICTOR OF ACUTE KIDNEY INJURY (AKI) IN FULL TERM ASPHYXIATED NEONATES
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