239 research outputs found
Scene thinking
No full textAn introduction is presented in which the author discusses several articles within the issue on topics including social research for scene thinking , genealogy development and Actor-Network Theory.Peer reviewedFinal article publishe
Postcard of a young man in a military uniform
No full textOn the back it says: "Compliments of the season, Jamie, P.S. thanks very much for the box. Postcard addressed to Mrs. Stuart. Added note on the bottom is "Jamie sent this from the Convalescent Depot where he is recovering from being gassed"
Beyond Jamie’s School Dinners: Social entrepreneurs and other actants in the moral geographies of young people and food
No full textOver the last decade school food has emerged as one of a number of ways in which concerns over children and young people’s health might be addressed. In 2005 Jamie Oliver, TV chef, emerged as a significant voice, championing the capacity of school food to avert a range of potentially detrimental health conditions. This chapter attempts to identify and analyze the ways in which the complex and ambiguous figure of Jamie Oliver has, and continues to claim some authority – in a variety of TV shows and social/moral enterprises such as Working in Jamie’s Kitchen and Jamie’s School Dinners –to intervene into what might be termed ‘the moral geographies of young people and food’. This chapter is concerned with those programs and interventions that aim to educate and encourage people (families, parents, young people, school teachers, dinners ladies) to make ‘better’ food choices in what has been called the battleground of school dining rooms. The intervention of social/moral entrepreneurs into these issues/spaces raise troubling questions not only about knowledge, expertise, authority in relation to young people, food and health but perhaps more significantly, who is/can/should be an actor in programs that overwhelmingly target the children of disadvantaged/poor families. Drawing on the work of Foucault and the late Stuart Hall the chapter explores how the figure of the moral entrepreneur might compel us to imagine the State as only one of a possible range of actors in the moral geographies of young people and food
Nothung up my sleeve : the Wagnerian impulses in James Joyce's Ulysses and A portrait of the artist as a young man
No full textBibliography : pages 245-249.The Introduction isolates the particular focus of the dissertation - viz. the importance of the Wagnerian themes and allusions in James Joyce's Ulysses and A Portrait of the Artist as a Young Man, considering existing studies of the same subject, as well as elucidating the structure and argument of the dissertation as a whole. In Chapters 111-V, the argument focuses on particular themes and characters in the operas that appear to influence Joyce, whether in terms of direct reference or oblique allusion. The focus of each of these three chapters is, respectively, the artist-hero, the father-son relationship and the symbolic role of woman
Molecular detection of Mycobacterium bovis in the environment
No full textAn investigation was carried out to determine the presence and persistence of
Mycobacterium bovis in the environment. Soil samples were taken in April 2000 from a
farm in Ireland which had undergone a bovine tuberculosis outbreak some four months
prior. Total community DNA was extracted from these samples and PCR carried out
targeted to two genes specific for the Mycobacterium tuberculosis complex; mpb64 and
mpb70. These genes were detected in soil samples taken from entrances to two badger
sets and in soil from two sites where the infected cattle grazed. Further analysis of DNA
using oligonucleotide primers specific for the 16S rRNA genes of slow-growing
mycobacteria was carried out. This revealed the presence of 16S rRNA genes relating to
Mycobacterium bovis. RT-PCR was also carried out using these primers on total
community RNA. Sequences relating to M. bovis were found, indicating that the DNA
and RNA came from viable, intact cells in the soil, and that M. bovis persists in soil for
up to four months after contamination of the soil. Sampling was repeated in November
2002 following a second TB outbreak in January 2001. DNA sequences for mpb64 and
mpb7O were only found in the samples from the badger setts, as were 16S rRNA
sequences.
The survival of the vaccine strain M. bovis BCG was also determined, using soil
microcosms experiments in defined environmental conditions. M. bovis BCG was found
to survive for longest at temperatures of 37°C and at soil wetting levels of 30%.
Culturable cells could not be detected after 60 days, however DNA and RNA relating to
M. bovis BCG could be detected up to 18 months after initial inoculation. This suggests
the cells persisted in a viable non-culturable state. Experiments to determine the rate of
persistence of DNA in soil were carried out. DNA was found to persist for no longer than
10 days in soil.
Diversity studies were carried out on the farm samples and on Warwick soil, to determine
the diversity of the mycobacterial population. 16S rRNA analysis was carried out and
showed the presence ofsequences relating to M. bovis, Al. hiberniae, M. avium, Al. fallax,
and M. farcinogenes
Molecular detection of Mycobacterium bovis in the environment
No full textAn investigation was carried out to determine the presence and persistence of Mycobacterium bovis in the environment. Soil samples were taken in April 2000 from a farm in Ireland which had undergone a bovine tuberculosis outbreak some four months prior. Total community DNA was extracted from these samples and PCR carried out targeted to two genes specific for the Mycobacterium tuberculosis complex; mpb64 and mpb70. These genes were detected in soil samples taken from entrances to two badger sets and in soil from two sites where the infected cattle grazed. Further analysis of DNA using oligonucleotide primers specific for the 16S rRNA genes of slow-growing mycobacteria was carried out. This revealed the presence of 16S rRNA genes relating to Mycobacterium bovis. RT-PCR was also carried out using these primers on total community RNA. Sequences relating to M. bovis were found, indicating that the DNA and RNA came from viable, intact cells in the soil, and that M. bovis persists in soil for up to four months after contamination of the soil. Sampling was repeated in November 2002 following a second TB outbreak in January 2001. DNA sequences for mpb64 and mpb7O were only found in the samples from the badger setts, as were 16S rRNA sequences. The survival of the vaccine strain M. bovis BCG was also determined, using soil microcosms experiments in defined environmental conditions. M. bovis BCG was found to survive for longest at temperatures of 37°C and at soil wetting levels of 30%. Culturable cells could not be detected after 60 days, however DNA and RNA relating to M. bovis BCG could be detected up to 18 months after initial inoculation. This suggests the cells persisted in a viable non-culturable state. Experiments to determine the rate of persistence of DNA in soil were carried out. DNA was found to persist for no longer than 10 days in soil. Diversity studies were carried out on the farm samples and on Warwick soil, to determine the diversity of the mycobacterial population. 16S rRNA analysis was carried out and showed the presence ofsequences relating to M. bovis, Al. hiberniae, M. avium, Al. fallax, and M. farcinogenes.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Arctic pedagogy in practice? A story of revitalisation of Scots language in an Aberdeenshire learning community and beyond
No full textAcknowledgements Thanks to Pausauraq Jana Harcharek, former director of the Iñupiaq Education Department, North Slope of Alaska, for inspiring the work 17 years ago and for sharing the Iñupiaq Framework and her wisdom. Thanks also to staff and pupils of Barrow High School, Kiita School and Nunamiut School for welcoming me to their classes. Thanks to my colleagues and the young people of Banff Academy for their thoughts, comments and responses about Scots in education. Many thanks to Stuart Clelland for suggesting I write this article and giving very useful comments and reading suggestions.Peer reviewe
Mediator and cohesin connect gene expression and chromatin architecture
No full textTranscription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound transcription factors and the transcription apparatus at the core promoter, but this process is not well understood. Here we report that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells. Mediator, a transcriptional coactivator, forms a complex with cohesin, which can form rings that connect two DNA segments. The cohesin-loading factor Nipbl is associated with mediator–cohesin complexes, providing a means to load cohesin at promoters. DNA looping is observed between the enhancers and promoters occupied by mediator and cohesin. Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell.National Institutes of Health (U.S.) (Fellowship)Canadian Institutes of Health Research (Research Fellowship)National Institutes of Health (U.S.) (Grant R01 HG002668
No effect of nitrate-rich beetroot juice on microvascular function and blood pressure in younger and older individuals: A randomised, placebo-controlled double-blind pilot study
No full textBackground / Objectives: To compare the effects of supplemental inorganic nitrate (NO3) on microvascular endothelial function and blood pressure in younger vs. older participants.
Subjects / Methods: 25 individuals participated in a double-blind, randomised, placebo-controlled crossover pilot study. Participants were stratified by age (18 – 35 and ≥ 55 years) and consumed a single dose beetroot juice (providing 6.4 mmol NO3) or NO3-depleted beetroot juice. Blood pressure, microvascular function (via Laser Doppler Flowmetry; LDF) and urinary NO3 were assessed, and the effects of NO3 supplementation on cardiovascular parameters were compared between participants and conditions using mixed design ANOVA.
Results: Treatments and methods were well tolerated, and no adverse events were reported. Urinary NO3 increased 3 hours following ingestion in both groups, (P = 0.02). Levels remained elevated at 24 hours post consumption in younger participants only (P = 0.02). Beetroot juice had no effect on blood pressure in either group nor on microcirculatory endothelial function.
Conclusions: Beetroot juice had no effect on blood pressure or microvascular endothelial function in young and older individuals. Dosage and timing regimens for supplemental beetroot juice should be avenues for further inquiry
Factors associated with emergency department service outcomes for people with a mental health problem brought in by police: a retrospective cohort study
No full textObjective This study aimed to identify factors associated with an emergency department (ED) length of stay ≥4 hours (h) and hospital admission for people with a mental health problem brought in by police. Methods We undertook a retrospective, observational cohort study of state-wide adult ED mental health presentations brought in by police from 1 January 2012 to 31 December 2017. We used multivariable logistic regression to determine factors associated with an ED length of stay ≥4 h and hospital admission. Results In total, 9325 ED presentations with a mental health problem brought in by police to Queensland EDs were included. Factors most strongly associated with an ED length of stay ≥4 h included an Australasian Triage Score (ATS) of 1, an age of 85 years or older, night shift arrival and subsequent hospital admission. For hospital admission, an ATS of 1, an age of 85 years or older and an ED length of stay ≥4 h were the strongest factors. Conclusion Findings indicate opportunities for targeted mental health models of care to better support people brought in by police to an ED. Such models should involve ED, pre-hospital providers (police and ambulance) and mental health services to support early intervention and potentially reduce the likelihood of a long ED length of stay and subsequent hospital admission.Full Tex
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