197 research outputs found
Supplemental Material - Risk Factors in Japanese Drug Overdose Patients: Identifying Their Associations With Suicide Risk
No full textSupplemental Material for Risk Factors in Japanese Drug Overdose Patients: Identifying Their Associations With Suicide Risk by Naomichi Okamoto, Atsuko Ikenouchi, Enkhmurun Chibaatar, Keita Watanabe, Ryohei Igata, Issei Seki, and Reiji Yoshimura in OMEGA - Journal of Death and Dying</p
Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes
No full textAtsuko Ikenouchi-Sugita, Reiji Yoshimura, Nobuhisa Ueda, Yuki Kodama, Wakako Umene-Nakano, Jun NakamuraDepartment of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, JapanAbstract: In the present study, the authors reported on a case in neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) with irreversible organic brain changes. The authors also longitudinally investigated serum brain-derived neurotrophic factor (BDNF) levels in the patient. We found that serum BDNF levels in the NPSLE patient with irreversible organic brain change were consistently low, independent of the severity of psychiatric symptoms. Thus, the longitudinal measurement of serum BDNF levels might be useful in predicting the prognosis of NPSLE.Keywords: brain-derived neurotrophic factor; neuropsychiatric syndrome of systemic lupus erythematosus; organic brain chang
Pure Just Tuning — Complete Harmonic Modulation with 8 Notes
No full textNote
This work is based on Reiji’s original ideas, verbal explanations, and handwritten notes in Japanese.
The English version has been translated by AI and organized by his guardian, with final approval from Reiji himself.
Abstract
This study proposes a novel theoretical approach to achieving a complete modulation system in pure just intonation using only eight notes.
Traditionally, just intonation provides exceptionally beautiful harmony within a single key, but suffers from pitch inconsistencies when modulating to other keys. This research introduces a unique method that combines progressions of perfect fifths and perfect fourths, enabling full key modulation while preserving pure just intonation.
The approach is designed using microtonal approximation, dimensional analysis, and frequency-space visualization, and is based on principles distinct from those of existing tuning systems such as Werckmeister III, Kirnberger III, Vallotti, and Young.
As a result, it theoretically achieves free modulation in pure just intonation—a capability that has long been considered impossible.
Authors: Reiji Konagaya (Primary Author), Nobuyuki Konagaya (Guardian, Co-author)
Update (v1.1):
Added a new figure, “Handwritten Diagram of Second Intervals in Pure Just Intonation,” illustrating the classification of second intervals (minor, neutral, and major) within the proposed tuning system. This addition enhances the visual explanation of the interval structure. No other changes were made to the main content.
Update (v1.2):
Added two new figures — “Handwritten Interval Map with Harmonic Ratios,” showing a sequential layout of pitches with their corresponding frequency ratios, and “Factorized Mathematical Representation of Tuning Ratios,” presenting each note’s ratio in multiple forms including prime factorization. These additions provide further clarity on both the musical and mathematical structure of the proposed tuning system. No other changes were made to the main content.
Update (v1.3):
Added one new figure, “Handwritten Structural Diagram of Pure Just Tuning,” which illustrates how each pitch ratio is derived and interconnected. In addition, new explanatory text was added to the sections “Definitions used in this article,” “Examples,” and “Fifths–Fourths relation,” further clarifying the theoretical framework of the system
A simple computational model of the evolution of a communicative trait and its phenotypic plasticity
No full textAbstract We consider a simple computational model of the evolution of a quantitative trait and its phenotypic plasticity based on directional and positive frequency-dependent selection in order to explore whether and how leaning might facilitate evolution under the dynamics that arise from communicative interactions among individuals. In the model, each individual expresses, at many different times in its lifetime, its real-valued trait depending on the probability distribution determined by its own genotypes. In communicative interactions between two individuals, the contribution of an interaction to the fitness is high when their trait values are close to each other as well as large, which represents the positive frequency-dependent and directional components of selection, respectively. The iterative interactions allow individuals to acquire a more adaptive trait pair through trial and error. Under the stochastic evolution process with the limited number of individuals, we show that learning allows the population to avoid getting stuck in the global but low optimum of the innate and individual-level fitness landscape via both aspects of the components of selection, and brings about the successful evolution by increasing the genetic variation of the population. We also analyze how such an effect of learning can be realized by measuring the degree of the two different contributions for increasing the adaptivity and similarity of communicative traits, respectively. We show that this effect of learning arises from these different types of contributions depending on the biological and environmental conditions such as the mutation rate and the duration of * Corresponding author Email addresses: [email protected] (Reiji Suzuki), [email protected] (Takaya Arita) Preprint submitted to Journal of Theoretical Biology April 8, 2013 communicative interactions. We further show the condition for the complete genetic assimilation to occur
Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder
No full textReiji Yoshimura, Asuka Katsuki, Kiyokazu Atake, Hikaru Hori, Ryohei Igata, Yuki KonishiDepartment of Psychiatry, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan Objectives: The etiology of depression remains unknown. There is, however, a growing body of evidence that cytokines are involved in the pathophysiology of depression. The aim of this study is to investigate the effects of fluvoxamine on plasma interleukin-6 (IL-6) levels and on clinical improvement of the depressive state.Subjects and methods: Thirty patients who met the DSM-IV criteria for major depressive disorder (MDD) were enrolled in the study. Thirteen were male and 17 were female, and their ages ranged from 26 to 70 years (mean ± standard deviation 45.0±14.2). The patients were treated with fluvoxamine for 8 weeks. The dosages of fluvoxamine varied among the patients and, based on ethical considerations, were not fixed.Results: The fluvoxamine doses were positively related to plasma fluvoxamine levels (r=0.8798, P<0.001). A significant correlation was observed between the patients’ plasma IL-6 levels and their 17-item Hamilton Rating Scale for Depression (HAMD17) scores (r=0.4555, P=0.0010). A positive correlation was found between the delta plasma IL-6 (week 0–week 8) and the delta HAMD17 (week 0–week 8) (r=0.5226, P=0.002).Conclusion: Effect of fluvoxamine on IL-6 is partially associated with its clinical efficacy for MDD. Keywords: fluvoxamine, interleukin, Hamilton Rating Scale for Depression, major depressive disorde
Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes
No full textPharmacokinetics, Clinical Effect and Side Effect of New Antidepressants, SSRI: 5. New Antidepressants Introducing to Japan Near Future
No full textPlasma Interleukin 6 Predicts Response to Serotonin Noradrenaline Reuptake Inhibitors in Major Depressive Disorder
No full textA CASE OF MAJOR DEPRESSION COMORBID WITH SOCIAL PHOBIA TREATED SUCCESSFULLY WITH VORTIOXETINE
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