332 research outputs found

    sj-pdf-1-vdi-10.1177_10406387231202529 – Supplemental material for Apocrine carcinoma-and-malignant myoepithelioma in a dog: a case of simultaneous malignant progression of both luminal epithelium and myoepithelium

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    Supplemental material, sj-pdf-1-vdi-10.1177_10406387231202529 for Apocrine carcinoma-and-malignant myoepithelioma in a dog: a case of simultaneous malignant progression of both luminal epithelium and myoepithelium by Kana Matsumoto, Takuya Evan Kishimoto, Masami Yamamoto, Masaki Michishita, Kimimasa Takahashi and Hisashi Yoshimura in Journal of Veterinary Diagnostic Investigation</p

    Supplemental Material, DS1_VET_10.1177_0300985818823772l - Expression and Roles of S100A4 in Anaplastic Cells of Canine Mammary Carcinomas

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    Supplemental Material, DS1_VET_10.1177_0300985818823772l for Expression and Roles of S100A4 in Anaplastic Cells of Canine Mammary Carcinomas by Hisashi Yoshimura, Aya Otsuka, Masaki Michishita, Masami Yamamoto, Minori Ashizawa, Manami Zushi, Maiko Moriya, Daigo Azakami, Kazuhiko Ochiai, Yoko Matsuda, Toshiyuki Ishiwata, Shinji Kamiya, and Kimimasa Takahashi in Veterinary Pathology</p

    Prevalence and correlates of regional pain and associated disability in Japanese workers

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    Objectives: to assess the prevalence and correlates of regional pain and associated disability in four groups of Japanese workers.Methods: as part of a large international survey of musculoskeletal symptoms (the CUPID study), nurses, office workers, sales/marketing personnel and transportation operatives in Japan completed a self-administered questionnaire (response rate 83%) covering experience of pain in six anatomical regions, associated disability and sickness absence, and various possible occupational and psychosocial risk factors for these outcomes. Associations with risk factors were assessed by logistic regression.Results: analysis was based on 2290 subjects. Rates of regional pain were generally less than in the UK, with a particularly low prevalence of wrist/hand pain among office workers (6% in past month). The strongest and most consistent risk factor for regional pain in the past month was tendency to somatise (ORs (95% CIs) for report of ?2 versus 0 distressing somatic symptoms 3.1 (2.4 to 4.0) for low back pain, 2.8 (2.1 to 3.8) for shoulder pain, and 2.5 (1.6 to 4.1) for wrist/hand pain). Sickness absence for regional pain complaints in the past year was reported by 5% of participants, the major risk factor for this outcome being absence during the same period for other medical reasons (OR 3.7, 95% CI 2.4 to 5.8).Conclusions: Japanese office workers have markedly lower rates of wrist/hand pain than their UK counterparts. In Japan, as in Western Europe, somatising tendency is a major risk factor for regional pain. Sickness absence attributed to regional pain complaints appears to be much less common in Japan than in the UK, and to be driven principally by a general propensity to take sickness absenc

    Special Economic Zones and Economic Corridors

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    Various reports show that special economic zones (SEZ) have become a prime catalyst for regional development in developing countries such as China and the ASEAN countries. The SEZ can be defined as a specific geographical region with economic laws that are more liberal than a country's typical economic laws. Many SEZs have characteristics of bonded zones, export processing zone (EPZ) or free trade zones and provide special incentives, including tax exemption or reduction to investors. The purpose of the paper is to enumerate the candidates for SEZ in Cambodia, Laos, Myanmar, and Vietnam (CLMV countries) according to four types: "metropolitan areas," "ports and harbors," "border areas" and "junctions or intersections." The first two types are based on the experience of forerunning ASEAN countries and the latter two are based on the economic corridors of the Greater Mekong Sub region Economic Cooperation Program. The paper concludes by identifying locations for the questionnaire and flowchart approach-based surveys, and presenting country-specific strategies.ASEAN, SEZ, Port, Harbor, Junction, Economic Corridor, CLMV, GMS.

    Disaster communication with African American, Black immigrant and refugee communities

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    prepared by: the Center for Public Service, Mark O. Hatfield School of Government, Portland State University ; Masami Nishishiba, Nhu To-Haynes, Carl Christiansen, Cameron Simmons.Title from PDF title page (viewed on October 19, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 26-28).Mode of access: Internet from the Oregon Government Publications Collection.Text in English

    Letter from incarcerees requesting release of prisoners, April 17, 1944

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    Letter from incarcerees requesting the release of 21 inmates from the army stockades at Tule Lake Camp. Names: Kazama, Masami; Shimada, Shunichi; Harauchi, Akio; Kusuda, Masanao; Gushiken, Yoshitsune; Gushiken, Yoshio; Matsumoto, Mitsuru; Matsumoto, Tsuneto; Masuoka, Hiro; Tarumoto, Sadaichi; Obara, Wataru; Shimamura, Hiroichi; Fujii, Yoshio; Aoki, Jin; Kurashige, Kenichi; Okata, Masanao; Nakahara, Tokushige; Morikawa, Masao; Morikawa, Shigeto; Yoshimura, Minoru; Takaishi, Awako; Takato, Jitsuo; Taniguchi, HitoshiThe Willard Schmidt collection, documents some of the administrative duties of Willard Schmidt, the Chief of Internal Security for the War Relocation Authority and the Tule Lake incarceration/segregation camp. This collection contains administrative records and photos documenting the Tule Lake camp, the largest incarceration camp with a peak population of 18,789 and with the most turbulent history. In 1943, the camp was turned into a segregation center to house "disloyal" Japanese Americans relocated from other camps based on their answers to a confusing loyalty questionnaire. The camp endured martial law from November 1943- Jan 1944 after escalating protests and unrest. The hostile environment of the camp lead to many incarcerees renouncing their American citizenship upon the end of incarceration, a process which took 14 years to reverse if they did not wish to be deported to Japan

    Preservation and Restoration of the International House of Japan

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    The International House of Japan (I-House) in Tokyo is a non-governmental organization that has promoted rich international intellectual exchanges. Designed by three young, up-and-coming architects Kunio Maekawa, Junzo Sakakura, and Junzo Yoshimura, the building of I-House in an exquisite modern Japanese style was built in 1955, but due to financial difficulties, the building was threatened with demolition. The Architectural Institute of Japan scrambled to assemble a special panel to present a conservation plan in 2004. Ultimately, the Board of Trustees decided to follow the panel’s proposal. This paper introduces the process of the restoration activities, discusses what were the driving forces of the preservation and restoration actions, and gives some lessons from the project

    Evidence for a role of nitric oxide in iron homeostasis in plants

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    Nitric oxide (NO), once regarded as a poisonous air pollutant, is now understood as a regulatory molecule essential for several biological functions in plants. In this review, we summarize NO generation in different plant organs and cellular compartments, and also discuss the role of NO in iron (Fe) homeostasis, particularly in Fe-deficient plants. Fe is one of the most limiting essential nutrient elements for plants. Plants often exhibit Fe deficiency symptoms despite sufficient tissue Fe concentrations. NO appears to not only up-regulate Fe uptake mechanisms but also makes Fe more bioavailable for metabolic functions. NO forms complexes with Fe, which can then be delivered into target cells/tissues. NO generated in plants can alleviate oxidative stress by regulating antioxidant defense processes, probably by improving functional Fe status and by inducing post-translational modifications in the enzymes/proteins involved in antioxidant defense responses. It is hypothesized that NO acts in cooperation with transcription factors such as bHLHs, FIT, and IRO to regulate the expression of enzymes and proteins essential for Fe homeostasis. However, further investigations are needed to disentangle the interaction of NO with intracellular target molecules that leads to enhanced internal Fe availability in plants.RKT is grateful to Department of Science and Technology-Science and Engineering Research Board (DST-SERB) New Delhi, for a Teachers Associateship for Research Excellence (TAR/2019/000064).Tewari, RK (corresponding author), Univ Lucknow, Dept Bot, Lucknow 226007, Uttar Pradesh, India. [email protected]

    Effects of straight chain alcohols on specific isoforms of adenylyl cyclase

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    BACKGROUND: Our previous studies showed that the activity of adenylyl cyclase (AC) was enhanced by pharmacologically relevant concentrations of ethanol, that this enhancing effect of ethanol on AC activity was AC isoform specific, and that the alcohol cutoff effect for n-alkanol potentiation of AC activity was also AC isoform specific. Therefore, we hypothesized that within the cyclic AMP-generating system, AC is the target of ethanol\u27s action and that alcohols interact directly with the AC molecules. To characterize the interaction between alcohols and AC proteins, the effects of a series of straight chain alcohols would be very valuable in understanding alcohol action at the molecular level. To our knowledge, straight chain alcohols other than n-alkanols and 1,Omega-diols have not been used extensively to study alcohol effects on the activity of AC or other proteins important in the alcohol research field. METHODS: The effects of a series of straight chain alcohols on D1A dopamine receptor-stimulated activity of AC isoforms type 6, 7, and 9 (AC6, AC7, and AC9) were examined in transfected Hela cells by a cAMP accumulation assay. RESULTS: In general, all 3 AC isoforms responded to a series of straight chain alcohols in a similar manner. The order of responsiveness is as follows: monoalcohol \u3e diol \u3e triol and tetraol. Within monoalcohols, 1-alcohols had larger effects than 2-alcohols. Two of 3 stereoisomers of 2,3-butanediol, [D-(-)-2,3-butanediol and meso-2,3-butanediol] showed similar enhancing effects on all 3 AC isoforms. However, the third stereoisomer, L-(+)-2,3-butanediol, inhibited AC7 activity, while it stimulated AC6 and AC9. CONCLUSION: The number and the position of hydroxyl groups in straight chain alcohols play an important role in the magnitude of the enhancement on AC activity. Regardless of AC isoforms, the most effective of the straight chain alcohols seems to be the 1-alcohol (n-alkanol) for a given chain length. We found that one of the stereoisomers of 2,3-butanediol had opposite effects on AC activity depending on the AC isoform. Overall, the results are consistent with the hypotheses and demonstrate that a series of straight chain alcohols can be a valuable tool to study AC-alcohol interactions
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