318 research outputs found
sj-docx-1-pcr-10.1177_26323524231214814 – Supplemental material for Facilitators and barriers to implementation of a patient and staff reported measure for screening of palliative concerns of patients with heart failure: a qualitative analysis using the Consolidated Framework for Implementation Research
No full textSupplemental material, sj-docx-1-pcr-10.1177_26323524231214814 for Facilitators and barriers to implementation of a patient and staff reported measure for screening of palliative concerns of patients with heart failure: a qualitative analysis using the Consolidated Framework for Implementation Research by Shirlyn Hui-Shan Neo, Jasmine Yun-Ting Tan, Elaine Swee-Ling Ng and Sungwon Yoon in Palliative Care and Social Practice</p
sj-pdf-1-ajh-10.1177_10499091211053624 – Supplemental Material for Factors Influencing Potentially Futile Treatments at the End of Life in a Multiethnic Asian Cardiology Setting: A Qualitative Study
No full textSupplemental Material, sj-pdf-1-ajh-10.1177_10499091211053624 for Factors Influencing Potentially Futile Treatments at the End of Life in a Multiethnic Asian Cardiology Setting: A Qualitative Study by Jamie J. Lo, Sungwon Yoon, Shirlyn Hui Shan Neo, David Kheng Leng Sim and Nicholas Graves in American Journal of Hospice and Palliative Medicine®</p
Recent advances in graphene monolayers growth and their biological applications: A review
No full textDevelopment of two-dimensional high-quality graphene monolayers has recently received great concern owing to their enormous applications in diverging fields including electronics, photonics, composite materials, paints and coatings, energy harvesting and storage, sensors and metrology, and biotechnology. As a result, various groups have successfully developed graphene layers on different substrates by using the chemical vapor deposition method and explored their physical properties. In this direction, we have focused on the state-of-the-art developments in the growth of graphene layers, and their functional applications in biotechnology. The review starts with the introduction, which contains outlines about the graphene and their basic characteristics. A brief history and inherent applications of graphene layers followed by recent developments in growth and properties are described. Then, the application of graphene layers in biodevices is reviewed. Finally, the review is summarized with perspectives and future challenges along with the scope for future technological applications. © 2020 Elsevier B.V.1
Stimulation of the Migration and Expansion of Adult Mouse Neural Stem Cells by the FPR2-Specific Peptide WKYMVm
No full textNeural stem cells (NSCs) are multipotent cells capable of self-renewal and differentiation into different nervous system cells. Mouse NSCs (mNSCs) are useful tools for studying neurogenesis and the therapeutic applications of neurodegenerative diseases in mammals. Formyl peptide receptor 2 (FPR2), expressed in the central nervous system and brain, is involved in the migration and differentiation of murine embryonic-derived NSCs. In this study, we explored the effect of FPR2 activation in adult mNSCs using the synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met-NH2 (WKYMVm), an agonist of FPR2. After isolation of NSCs from the subventricular zone of the adult mouse brain, they were cultured in two culture systems—neurospheres or adherent monolayers—to demonstrate the expression of NSC markers and phenotypes. Under different conditions, mNSCs differentiated into neurons and glial cells such as astrocytes, microglia, and oligodendrocytes. Treatment with WKYMVm stimulated the chemotactic migration of mNSCs. Moreover, WKYMVm-treated mNSCs were found to promote proliferation; this result was confirmed by the expansion of mNSCs in Matrigel and the increase in the number of Ki67-positive cells. Incubation of mNSCs with WKYMVm in a supplement-free medium enhanced the survival rate of the mNSCs. Together, these results suggest that WKYMVm-induced activation of FPR2 stimulates cellular responses in adult NSCs
Large phase change by cascaded second-order effects in 3-methyl-4-methoxy-4''-nitrostilbene single crystals
No full textLarge phase change by cascaded second-order effect in 3-methyl-4-methoxy-4'-nitrostilbene (MMONS) single crystals
No full textA systematic reallocation and prioritization scheme for error-resilient transmission of video packets
No full textThis paper proposes a novel video transmission scheme that provides error-resilient transmission of encoded video on a per-packet basis over wireless networks. In conventional schemes, the error-resilient transmission of encoded video has been conducted using the unit of a video frame or data partition. However, in order to provide higher error-resilient transmission for significant video data that critically impacts the decoding when it is lost, the unit of prioritized video transmission should be more fine-grained. Moreover, the transmission overhead incurred by the application of the prioritized video transmission should be further minimized. In order to overcome these limitations, this paper proposes a scheme that identifies and reallocates significant video data within the unit of inter-frame dependency, which is a hierarchical relationship between video frames, in order to enhance the compression efficiency such as a group of pictures. Consequently, the encoded video is transmitted with different transmission priorities on a per-packet basis depending on the packet's significance for decoding. The evaluation results with standard definition and high definition videos demonstrate that the proposed scheme has significant performance enhancements over the conventional video frame prioritization scheme in terms of transmission overhead, transmitted video data utilization, peak signal-to-noise ratio, and subject quality test.
Interoperability test suite derivation for communication protocols
No full textThis paper addresses the problem of interoperability testing for communication protocols. We develop a coherent framework of interoperability testing in which the notions of interoperability, interoperability testing, interoperability test case and interoperability test architecture are interrelated and a systematic interoperability test suite derivation method based on the framework, The approach to interoperability testing is illustrated with the example of the ATM Signaling Protocol. To demonstrate practicality of the approach, we implemented executable test suites derived by the method on a commercial ATM test platform, applied them for interoperability testing of various ATM equipment and analyzed the testing results. (C) 2000 Elsevier Science B.V. All rights reserved.We are grateful to the referees whose insightful
remarks considerably helped to improve the
quality of the paper. Many thanks to Mr. David
Cypher, NIST, USA, who went over the paper
carefully and quickly and suggested numerous
improvements not only in English but also in
technical terms with his expertise in communication
protocol testing. The ®rst author would like to
thank Prof. Arthur Fleck, University of Iowa,
USA, for his encouragement in this work and
other adventures of the ®rst author for many
years
LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries
No full textNeurexins (Nrxns) and LAR-RPTPs (leukocyte common antigen-related protein tyrosine phosphatases) are presynaptic adhesion proteins responsible for organizing presynaptic machineries through interactions with nonoverlapping extracellular ligands. Here, we report that two members of the LAR-RPTP family, PTPr and PTPd, are required for the presynaptogenic activity of Nrxns. Intriguingly, Nrxn1 and PTPr require distinct sets of intracellular proteins for the assembly of specific presynaptic terminals. In addition, Nrxn1a showed robust heparan sulfate (HS)-dependent, high-affinity interactions with Ig domains of PTPr that were regulated by the splicing status of PTPr. Furthermore, Nrxn1a WT, but not a Nrxn1a mutant lacking HS moieties (Nrxn1a DHS), inhibited postsynapse-inducing activity of PTPr at excitatory, but not inhibitory, synapses. Similarly, cis expression of Nrxn1a WT, but not Nrxn1a DHS, suppressed the PTPr-mediated maintenance of excitatory postsynaptic specializations in mouse cultured hippocampal neurons. Lastly, genetics analyses using male or female Drosophila Dlar and Dnrx mutant larvae identified epistatic interactions that control synapse formation and synaptic transmission at neuromuscular junctions. Our results suggest a novel synaptogenesis model whereby different presynaptic adhesion molecules combine with distinct regulatory codes to orchestrate specific synaptic adhesion pathways. © 2020 the authors1
Ideas, institutions, and interests in the global governance of epidemics in Asia
No full textRecent policy debates provide mounting evidence that global governance of epidemics in Asia is evolving with the rise of new actors, agendas, and programs to address the transnational nature of public health emergencies. However, there have been relatively few studies that address the question of why certain public health approaches are preferred. Drawing on the case studies of severe acute respiratory syndrome and H5N1 avian influenza, this article sets out to answer 2 questions about global governance of epidemics in Asia: What set of ideas characterizes the form of global governance of epidemics in Asia? Why does it prevail while other alternatives fall by the wayside? The central argument in this article is that the global public health agenda and action by policy communities are not only shaped by empirical realities of public health but are also the result of the contending sets of interests and concerns
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