3,359 research outputs found
Opportunities for linking young surveyors across professional surveying member organisations and FIG
No full textAssociation of TIM-3 expression with glucose metabolism in Jurkat T cells
No full textBACKGROUND: T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation and leads to insufficient immunity in cancer and chronic infection. TIM-3 regulates T cell activation possibly through alterations in metabolism; however, the relationship between TIM-3 expression and T cell metabolic changes has not been well studied. RESULTS: We investigated the association between TIM-3 expression and metabolic changes by analyzing glucose metabolism, glutamine metabolism, and mitochondrial function in TIM-3 overexpressing or knockout Jurkat T cell lines relative to their control cell lines. Glucose uptake and consumption, and lactate release were downregulated by TIM-3 expression but upregulated by TIM-3 knockout. Concomitantly, the expression of the glucose transporter, Glut1, but not Glut2, 3, or 4 was altered by TIM-3 expression. However, TIM-3 expression alone could not account for the change in glutamine consumption, glutamate release, and mitochondrial mass, ROS production or membrane potential in these cell lines. CONCLUSION: Our results show the association of TIM-3 expression with T cell glucose metabolism. These results are significant in chronic infections and cancers where it is necessary to control TIM-3 expressing T cells
Supplemental Material, GSJ_Supplemental_Material - Cell Therapy for Treatment of Intervertebral Disc Degeneration: A Systematic Review
No full textSupplemental Material, GSJ_Supplemental_Material for Cell Therapy for Treatment of Intervertebral Disc Degeneration: A Systematic Review by Dino Samartzis, Niccole M. Germscheid, Michael G. Fehlings, Charles G. Fisher, Marinus de Kleuver, F. Cumhur Öner, S. Tim Yoon, Luiz R. Vialle, Hans-Joerg Meisel, Neha Agarwal, Patrick C. Hsieh, Andrea Skelly, Jong-Beom Park, Darrel Brodke, Jeffrey C. Wang, S. Tim Yoon and Zorica Buser in Global Spine Journal</p
Supplemental Material - Dosing Strategy for Osteobiologics Used in Acdf Surgery, Influence on Fusion Rates and Associated Complications. A Systematic Literature Review
No full textSupplemental Material for Dosing Strategy for Osteobiologics Used in Acdf Surgery, Influence on Fusion Rates and Associated Complications. A Systematic Literature Review by Waeel O. Hamouda, Sotiris Veranis, Oscar Krol, Navraj S. Sagoo, Peter G. Passias, Zorica Buser, Hans Joerg Meisel and Tim Yoon in Global Spine Journal</p
Supplemental Material, autologous_sc_lumbar_spinal_fusion_final_appendices_03-24-2020 - Use of Autologous Stem Cells in Lumbar Spinal Fusion: A Systematic Review of Current Clinical Evidence
No full textSupplemental Material, autologous_sc_lumbar_spinal_fusion_final_appendices_03-24-2020 for Use of Autologous Stem Cells in Lumbar Spinal Fusion: A Systematic Review of Current Clinical Evidence by Zorica Buser, Patrick Hsieh, Hans-Joerg Meisel, Andrea C. Skelly, Erika D. Brodt, Darrel S. Brodke, Jong-Beom Park, S. Tim Yoon, Jeffrey Wang and AO KF Degenerative in Global Spine Journal</p
UTSim2 validation
No full textThe Center for NDE (CNDE) at Iowa State University has a long history of developing physics models for NDE and packaging these models into simulation tools which make the modeling capabilities accessible to CNDEs industrial sponsors. Recent work at CNDE has led to the development of a new ultrasonic simulation package, UTSim2, which aims to continue this tradition of supporting industrial application of CNDE models. In order to meet this goal, UTSim2 has been designed as an extensible software package which can support previously-developed physics models as well as future models yet to be developed. Initial work has focused on the implementation of a Gauss-Hermite beam model, a paraxial approximation, which is implemented as part of the Thompson-Gray measurement model. This paper will present recent validation results and include comparisons against both previously-validated model output and newly-performed experiments.This proceeding may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This proceeding appeared in Grandin, Robert, and Tim Gray. "UTSim2 validation." AIP Conference Proceedings, 1806, no. 1 (2017): 150007, and may be found at DOI: 10.1063/1.4974731. Posted with permission.</p
Evaluating Citebase, an open access Web-based citation-ranked search and impact discovery service
No full textCitebase is a new citation-ranked search and impact discovery service that measures citations of scholarly research papers which are openly accessible on the Web, i.e. papers that are assessable continuously online. Other services, such as ResearchIndex, have emerged in recent years to offer citation indexing of Web research papers. In the first detailed user evaluation of an open access Web citation indexing service, Citebase has been evaluated by nearly 200 users from different backgrounds. The paper details the procedures used in the evaluation, and analyses the results of this study, which took place between June and October 2002. It was found that within the scope of its primary components, the search interface and services available from its rich bibliographic records, Citebase can be used simply and reliably for the purpose intended, and that it compares favourably with other bibliographic services. It is shown tasks can be accomplished efficiently with Citebase regardless of the background of the user. More data need to be collected and the process refined before it is as reliable for measuring citation impact of indexed papers. Better explanations and guidance are required for first-time users. Coverage is seen as a limiting factor, even though Citebase indexes over 200,000 papers from arXiv. Non-physicists were frustrated at the lack of papers from other sciences. The principle of citation searching of open access archives has thus been demonstrated and need not be restricted to current users. Since the evaluation, Citebase has become a featured service of the ArXiv physics eprint archives
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Putting the S-word back into Sustainability: Can we be more social?
No full textIn an era dominated by climate change debate and environmentalism
there is a real danger that the important ‘social’ pillar of sustainability
drops out of our vocabulary. This can happen at a variety of scales from
business level through to building and neighbourhood level regeneration
and development. Social sustainability should be at the heart of all
housing and mixed-use development but for a variety of reasons tends
to be frequently underplayed. The recent English city riots have brought
this point back sharply into focus. The relationships between people,
places and the local economy all matter and this is as true today as
it was in the late 19th century when Patrick Geddes, the great
pioneering town planner and ecologist, wrote of ‘place-work-folk’.
This paper, commissioned from Tim Dixon, explains what is meant by
social sustainability (and how it is linked to concepts such as social capital
and social cohesion); why the debate matters during a period when
‘localism’ is dominating political debate; and what is inhibiting its growth
and its measurement. The paper reviews best practice in post-occupancy
social sustainability metric systems, based on recent research undertaken
by the author on Dockside Green in Vancouver, and identifi es some of
the key operational issues in mainstreaming the concept within major
mixed-use projects. The paper concludes by offering a framework for the
key challenges faced in setting strategic corporate goals and objectives;
prioritising and selecting the most appropriate investments; and measuring
social sustainability performance by identifying the required data source
Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells
No full textGSJ883256_Appendix1 - Structural Allograft Versus PEEK Implants in Anterior Cervical Discectomy and Fusion: A Systematic Review
No full textGSJ883256_Appendix1 for Structural Allograft Versus PEEK Implants in Anterior Cervical Discectomy and Fusion: A Systematic Review by Amit Jain, Majd Marrache, Andrew Harris, Varun Puvanesarajah, Brian J. Neuman, Zorica Buser, Jeffrey C. Wang, S. Tim Yoon, Hans Jörg Meisel and AOSpine Knowledge Forum Degenerative in Global Spine Journal</p
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