49 research outputs found
Social practice in the legal secretariat of the municipality of Bucaramanga to monitor and control court rulings on class actions duly enforced in the second instance, for which the infrastructure secretariat has been designated for compliance from September 19, 2004, to July 31, 2025.
No full textTítulo: Practica social en la secretaría jurídica del municipio de Bucaramanga para realizar el
seguimiento y control de los fallos judiciales de acciones populares debidamente ejecutoriados en
segunda instancia que para su cumplimiento se haya designado a la secretaría de infraestructura
desde el 19 de septiembre de 2004 hasta el 31 de julio de 2025.
Autor: Gamaliel Eliu Garcia Rojas
Palabras Clave: Sistema Jurídico Integral, SAMAI, Consulta de Procesos Nacional Unificada
Descripción: El Municipio de Bucaramanga es un ente territorial encargado del desarrollo y el
mejoramiento de la calidad de vida de sus habitantes, basado en la efectividad, transparencia y
legalidad, prestando oportuna y eficientemente servicios a los diferentes sectores de la comunidad,
acorde a las necesidades de la ciudadanía, las exigencias del medio y el cumplimiento de la
Constitución y las Leyes, fomentando el autocontrol y la autogestión, para alcanzar la satisfacción
de los usuarios. Centrada en un sistema de gerencia participativa, garantizando la identificación y
la prevención de las condiciones y factores que afectan la salud y seguridad de los servidores
públicos, para garantizar un ambiente de trabajo adecuado, el uso eficiente de los recursos y el
compromiso para estar a la vanguardia en conocimientos, técnicas y metodologías que contribuyan
al desarrollo de la competitividad y continua del Sistema Integrado de Gestión de Calidad.
En el marco de sus competencias el municipio de Bucaramanga debe propender por la defensa
judicial en todas sus dependencias y la prevención del daño antijurídico, en ese sentido, esta
práctica en la secretaría jurídica busca identificar falencias y corregirlas en el cumplimiento de los
fallos judiciales producto de acciones populares ejecutoriadas en segunda instanciaPregradoAbogadoTitle: Social practice in the legal secretariat of the municipality of Bucaramanga to monitor and
control court rulings on class actions duly enforced in the second instance, for which the
infrastructure secretariat has been designated for compliance from September 19, 2004, to July 31,
2025.
Author: Gamaliel Eliu Garcia Rojas
Key Words: Comprehensive Legal System, SAMAI, Unified National Process Inquiry
Description: The Municipality of Bucaramanga is a territorial entity responsible for the
development and improvement of the quality of life of its inhabitants, based on effectiveness,
transparency, and legality, providing timely and efficient services to different sectors of the
community, in accordance with the needs of citizens, the demands of the environment, and
compliance with the Constitution and laws, promoting self-control and self-management to
achieve user satisfaction. Focused on a participatory management system, it guarantees the
identification and prevention of conditions and factors that affect the health and safety of public
servants, to ensure an adequate work environment, the efficient use of resources, and a
commitment to being at the forefront of knowledge, techniques, and methodologies that contribute
to the development of competitiveness and the continuity of the Integrated Quality Management
System.
Within the scope of its powers, the municipality of Bucaramanga must strive for legal defense in
all its departments and the prevention of unlawful damage. In this regard, this practice in the legal
secretariat seeks to identify shortcomings and correct them in compliance with court rulings
resulting from popular actions enforced in the second instance
La postura de garante de los altos funcionarios como criterio configurador del delito de homicidio doloso en las manifestaciones sociales
No full textEl presente trabajo de investigación tiene como fin determinar criterios jurídicos en la postura de garante de los altos funcionarios, a partir del análisis y verificación del estatus que poseen, en razón del cargo, como criterio configurador del delito de homicidio doloso en las manifestaciones sociales. La tesis explora-como referencia-la denuncia constitucional N°1502020, en contra del ex Presidente Merino
de Lama,
como
presunto
autor
del
delito
en
cuestión.
De
ahí
que, se estudió el delito de omisión impropia, en tanto que, el sujeto activo/autor tiene incito el nexo
de evitación, por lo que, está obligado a evitar que se produzca el resultado lesivo, y permite que se
afecte al bien jurídico.
Frente a ello, el estudio desarrollado tiene sustento en la tesis de infracción de deber, en la cual el estatus
del alto funcionario por su condición especial y personal, no tiene relación directa con el resultado lesivo en el delito de homicidio.
En tal sentido,no es posible pretender encajar la tesis del dominio del hecho, por cuanto, no domina
ni el riesgo típico que exige un deber específico-deber que el Presidente no defrauda-previsto en una
norma extra-penal.
De ahí que, se propone la implementación de los criterios jurídicos de: el nexo de evitación, la previsibilidad y el hombre promedio en sociedad; en la postura de garante.
Y a fin de operativizar los conceptos propuestos, se concluye que, no es posible atribuir responsabilidad
penal al Presidente de la República.The purpose of this research work is to determine legal criteria regarding the position of guarantor held by high-ranking officials, based on the analysis and verification of the status they possess by virtue of their office, as a determining factor in the crime of intentional homicide during social demonstrations. The thesis explores, as a reference, the constitutional complaint No. 150-2020 against former President Merino de Lama as the alleged author of the aforementioned crime. From there, improper omission offenses were studied, considering that the active/author subject has a duty to prevent the harmful outcome and allows the infringement of the legal interest. In light of this, the study is grounded in the theory of breach of duty, in which the status of a high-ranking official, due to their special and personal condition, does not have a direct relationship with the harmful outcome in the crime of homicide. Thus, it's not possible to fit the theory of control of the act, as there is no control over the typical risk that
requires a specific duty - a duty that the president does not breach - provided by an extrapenal norm. Therefore, the implementation of the following legal criteria in the position of guarantor is proposed: the duty to prevent, foreseeability, and the average person in society. In order to operationalize the proposed concepts, it is concluded that it is not possible to attribute criminal responsibility to the President of the Republic
Effect of age on the pathogenesis of Duck Tembusu virus in Cherry Valley ducks
No full textThe effect of host age on the outcome of Duck Tembusu virus (DTMUV) infection was studied in ducks. Three groups of Cherry Valley ducks at 1, 3 and 7 weeks of age were intramuscularly infected with DTMUV to systematically observe the clinical symptoms, pathological changes, tissue viral loads and immune responses. Severe clinical symptoms and neurological dysfunction were observed in 1-week-old ducks as early as 2 day post infection (dpi) and some died at 5 –7 dpi. Three week old ducks showed similar but milder symptoms and no deaths. However, 7-week-old ducks showed only transient loss of appetite. Gross lesions gradually reduced in severity as ducks matured. One week old ducks showed endocardial haemorrhage, splenomegaly, swelling in the lymph follicles of the ileum, liver and kidney swelling with degeneration, and meningeal hyperemia. Three week old ducks showed only mild pathological lesions. No visible lesions were observed in 7-week-old ducks. However, pathological histology analysis demonstrated all infected ducks displayed viral encephalitis. DTMUV could be detected in the brains of 1-week-old ducks as early as 1 dpi and virus titers of most organs in 1-week-old ducks were significantly higher than that of 3- and 7-week-old ducks at 3 –5 dpi. The patterns of IFN-γ, IL-2, and serum neutralizing antibodies were similar, and there were significant difference between the youngest ducks and the older ducks at early infection stage (P<0.05). More important is that although the antibody titers of all infected ducks were similar from 9 dpi to 17 dpi, reduced clearance of virus was observed in the youngest groups comparing with the other two groups, indicating that immune system maturity was more important than the presence of neutralizing antibody. In summary, this study demonstrates that viral pathogenesis is strongest in 1-week-old ducks and the age-related immune response plays an important role in the pathogenesis of DTMUV in ducks
The time course of contextual effects on visual word recognition
No full textSentence comprehension depends on continuous prediction of upcoming words. However, when and how contextual information affects the bottom-up streams of visual word recognition is unknown. This study examined the effects of word frequency and contextual predictability (cloze probability of a target word embedded in the sentence) on N1, P200, and N400 components, which are related to various cognitive operations in early visual processing, perceptual decoding, and semantic processing. The data exhibited a significant interaction between predictability and frequency at the anterior N1 component. The predictability effect, in which the low predictability words elicited a more negative N1 than high predictability words, was only observed when reading a high frequency word. A significant predictability effect occurred during the P200 time window, in which the low predictability words elicited a less positive P200 than high predictability words. These data suggest that the contextual information facilitate visual-feature detection and orthographic pre-activation in the early stage of visual word processing. There is also a significant predictability effect on the N400 component; low predictability words elicited a greater N400 than high predictability words, although this effect did not interact with frequency. The temporal dynamics of the manner in which contextual information affects the visual word recognition is discussed. These findings support the interactive account, suggesting that contextual information facilitates visual-feature and orthographic processing in the early stage, and semantic integration in the later stage
Structure and function of SLC4 family HCO3– transporters
No full textThe SLC4 family contains 10 members, nine of which are HCO3– transporters, including three Na+-independent Cl−/HCO3– exchangers AE1, AE2, and AE3, five Na+-coupled HCO3– transporters NBCe1, NBCe2, NBCn1, NBCn2, and NDCBE, as well as AE4 whose Na+-dependence remains controversial. The SLC4 HCO3– transporters play critical roles in pH regulation and transepithelial movement of electrolytes with a broad range of physiological relevances. Dysfunctions of these transporters are associated with a series of human diseases. During the past decades, tremendous amount of efforts have been undertaken to investigate the topological organization of the SLC4 transporters in the plasma membrane. Based upon the proposed topology models, mutational and functional studies have identified important structural elements likely involved in the ion translocation by the SLC4 transporters. In the present article, we will review the advances during the past decades in understanding the structure and function of the SLC4 transporters
Deep learning methods for enabling real-time gravitational wave and multimessenger astrophysics
No full textA new era of gravitational wave (GW) astronomy has begun with the recent detections by LIGO. However, we need real-time observations of GW signals and their electromagnetic (EM) and astro-particle counterparts to unlock its full potential for scientific discoveries. Extracting and classifying the wide range of modeled and unmodeled GWs, whose amplitudes are often much weaker than the background noise, and rapidly inferring accurate parameters of their source is crucial in enabling this scenario of real-time multimessenger astrophysics. Identifying and automatically clustering anomalous non-Gaussian transient noises (glitches) that frequently contaminate the data and separating them from true GW signals is yet another difficult challenge.
Currently, the most sensitive data analysis pipelines are limited by the extreme computational costs of template-matching methods and thus are unable to scale to all types of GW sources and their full parameter space. Accurate numerical models of GW signals covering the entire range of parameters including eccentric and spin-precessing compact binaries, which are essential to infer the astrophysical parameters of an event, are not available. Searches for unmodeled and anomalous signals do not have sufficient sensitivity compared to the targeted searches. Furthermore, existing search pipelines are not optimal for dealing with the non-stationary, non-Gaussian noise in the detectors. This indicates that many critical events will go unnoticed. The primary objective of this thesis is to resolve these issues via deep learning, a state-of-the-art machine learning method based on artificial neural networks.
In this thesis we develop robust GW analysis algorithms for analyzing real LIGO/Virgo data based on deep learning with neural networks, that overcomes many limitations of existing techniques, allowing real-time detection and parameter estimation modeled GW sources and unmodeled GW bursts as well as classification and unsupervised clustering of anomalies and glitches in the detectors. This pipeline is designed to be highly scalable, therefore it can be trained with template banks of any size to cover the entire parameter-space of eccentric and spin-precessing black hole binaries as well as other sources and also optimized based on the real-time characteristics of the complex noise in the GW detectors.
This deep learning framework may also be extended for low-latency analysis of the raw big data collected across multiple observational instruments to further facilitate real-time multimessenger astrophysics, which promises groundbreaking scientific insights about the origin, evolution, and destiny of the universe. In addition, this work introduces a new paradigm to accelerate scientific discovery by using data derived from high-performance physics simulations on supercomputers to train artificial intelligence algorithms that exploit emerging hardware architectures.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01The student, Daniel George, accepted the attached license on 2018-12-06 at 00:49.The student, Daniel George, submitted this Dissertation for approval on 2018-12-06 at 01:03.This Dissertation was approved for publication on 2018-12-07 at 07:40.DSpace SAF Submission Ingestion Package generated from Vireo submission #13229 on 2019-02-08 at 11:41:24Made available in DSpace on 2019-02-08T18:44:40Z (GMT). No. of bitstreams: 2
GEORGE-DISSERTATION-2018.pdf: 17941667 bytes, checksum: e0e0c87bdfc2d80f0f05249fe6629633 (MD5)
LICENSE.txt: 4210 bytes, checksum: e8bea6db131931d703d8fb97bb52f411 (MD5)
Previous issue date: 2018-12-07Embargo set by: Seth Robbins for item 109973
Lift date: 2021-02-08T18:44:50Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 109973 on 2021-02-09T10:15:30Z
High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice
No full textOsteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer’s disease (AD) than the age-matched non-dementia individuals. Given that there is no evidence that overweight associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In the present study, feeding a high-fat-diet (HFD, 45% calorie from fat) to female APP/PS1 transgenic mice, an AD animal model, induced weight gain. The bone mineral density, microarchitecture, and biomechanical properties of the femurs were then evaluated. The results showed that the middle-aged female APP/PS1 transgenic mice were susceptible to osteoporosis of the femoral bones and that weight gain significantly enhanced bone mass and mechanical properties. Notably, HFD was not detrimental to brain insulin signaling and AβPP processing, as well as to exploration ability and working, learning and memory performance of the transgenic mice measured by T maze and water maze, compared with the mice fed a normal fat diet (10% calorie from fat). In addition, the circulating levels of leptin but not estradiol were remarkably elevated in HFD-treated mice. These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin
Genome-wide analysis of the AP2/ERF superfamily genes and their responses to abiotic stress in Medicago truncatula
No full textThe AP2/ERF superfamily is a large, plant-specific transcription factor family that is involved in many important processes, including plant growth, development and stress responses. Using Medicago truncatula genome information, we identified and characterized 123 putative AP2/ERF genes, which were named as MtERF1–123. These genes were classified into four families based on phylogenetic analysis, which is consistent with the results of other plant species. MtERF genes are distributed throughout all chromosomes but are clustered on various chromosomes due to genomic tandem and segmental duplication. Using transcriptome, high-throughput sequencing data and qRT-PCR analysis, we assessed the expression patterns of the MtERF genes in tissues during development and under abiotic stresses. In total, 87 MtERF genes were expressed in plant tissues, most of which were expressed in specific tissues during development or under specific abiotic stress treatments. These results support the notion that MtERF genes are involved in developmental regulation and environmental responses in M. truncatula. Furthermore, a cluster of DREB subfamily members on chromosome 6 was induced by both cold and freezing stress, representing a positive gene regulatory response under low temperature stress, which suggests that these genes might contribute to freezing tolerance to M. truncatula. In summary, our genome-wide characterization, evolutionary analysis and expression pattern analysis of MtERF genes in M. truncatula provides valuable information for characterizing the molecular functions of these genes and utilizing them to improve stress tolerance in plants
LPAIV H9N2 drives the differential expression of goose interferons and proinflammatory cytokines in both in vitro and in vivo studies
No full textGeese, as aquatic birds, are an important natural reservoir of avian influenza virus (AIV). To characterize the innate antiviral immune response against AIV H9N2 strain infection in geese as well as the probable relationship between the expression of immune-related genes and the distribution of viral antigens, we investigated the levels of immune-related gene transcription both in AIV H9N2 strain-infected geese and in vitro. The patterns of viral location and the tissue distribution of CD4- and CD8α-positive cells were concurrently detected by immunohistochemical staining, which revealed respiratory and digestive organs as the primary sites of antigen-positive signals. Average AIV H9N2 viral loads were detected in the faeces, Harderian gland and trachea, where higher copy numbers were detected compared with the rectum. Our results suggested the strong induction of proinflammatory cytokine expression compared with interferons (IFNs). Notably, in most tissues from the AIV H9N2 strain-infected birds, IFNα and IFNγ gene transcripts were differentially expressed. However, inverse changes in IFNα and IFNγ expression after AIV H9N2 strain infection were observed in vitro. Taken together, the results suggest that AIV H9N2 is widely distributed in multiple tissues, efficiently induces inflammatory cytokines in the Harderian gland and spleen of goslings and inversely influences type I and II IFN expression both in vivo and in vitro. The findings of this study further our understanding of host defence mechanisms and the pathogenesis of the H9N2 influenza virus in geese
Respiratory Sensory Gating measured by Respiratory-Related Evoked Potentials in Generalized Anxiety Disorder
No full textThe perception of respiratory sensations plays an important role both in respiratory diseases and in anxiety disorders. However, little is known about the neural processes underlying respiratory sensory perception, especially in patient groups. Therefore, the present study examined whether patients with generalized anxiety disorder (GAD) would demonstrate altered respiratory sensory gating compared to a healthy control group. Respiratory-related evoked potentials (RREP) were measured in a paired inspiratory occlusion paradigm presenting two brief occlusion stimuli (S1 and S2) within one inspiration. The results showed a significantly greater S2/S1 ratio for the N1 component of the RREP in the GAD group compared to the control group. Our findings suggest altered respiratory sensory processing in patients with GAD, which might contribute to altered perception of respiratory sensations in these patients
