3,118 research outputs found
Fast-Synthesis of alpha-Phosphonyloxy Ketones as Drug Scaffolds in a Capillary Microreactor
No full textA simple, room temperature approach for the fast single-step synthesis of alpha-phosphonyloxy ketone, a drug scaffold, has been developed which involves highly reactive species i.e., 1,2-dicarbonyls that readily react with trialkyl phosphites and formic acids in batch as well as in continuous-flow with the flow rate of 3 ml/min (t (R) = similar to 4 s). The present approach reduced the synthesis time from hours to minutes in batch, which was further lowered to a few seconds precisely controlled by single capillary microfluidics. A wide range of 1,2-dicarbonyl derivatives were smoothly transformed to their corresponding alpha-phosphonyloxy ketones in moderate to good yields (50-82 %) under optimized flow-reaction conditions. Further, the alpha-phosphonyloxy ketones produced can be utilized in batch process to form benzoin, oxazole core, and alpha,alpha '-diarylated carbonyl compounds in 82 %, 50 %, and 54 % yields, respectively, which are alternative key precursors/scaffolds of natural products and active pharmaceutical ingredients (APIs).11Nsciescopu
Walter E. Oberer Retirement Luncheon
No full textDean Oberer was emeritus of law and former dean of the S.J. Quinney College of Law. He received the Burlington Resources Foundation Faculty Achievement Award in 1991 and was particularly noted for his scholarship in labor law and was co-author of a book, "Cases and Materials on Labor Law: Collective Bargaining in a Free Society.
Arsaces Armeniae rex in scenam dabitvr ab auctoribus & actoribus eloquentiæ studiosis in collegio societatis Iesv Antverpiæ die [ ] ianuarij, M.DC.XXXIX.
No full textProbably printed in AntwerpBacker-Sommervogel [S.J.] VIII, 1667, nr. 30bis; VIII, 9, nr. 1 (mentions Gilles Thybault as the author)Europeana-GoogleBook
Daily Reflections (Meditations) on the Scriptures from the Roman Catholic Lectionary.
No full textThe recipients of the Letter to the Hebrews were folks who were flagging in their commitment to faith and the Christian life. The author addresses their lack of faith in the sacrifice and priesthood of Jesus. Hebrews has been the focus of the first readings in Ordinary Time since the ending of the Christmas season.|We all need to hear that message of the author because of our need to grow in faithfulness and love as we encounter the daily-ness of our lives. Let's look at just one of the features expressed in the first reading for today's liturgy.|The reading is from the last chapter of Hebrews, a kind of summary of how to live effectively with the will to follow Jesus and make that following effective in their everyday lives. The people are exhorted to live simply and to trust that "the Lord is my helper and I will not be afraid. What can anyone do to me?"|The virtues they are called to live out seem to be fundamental for living the Christ-life within them (and, clearly, within us): "do not neglect hospitality;" "be mindful of prisoners;" "let marriage be honored;" "let your life be free from love of money." How do these injunctions relate to us today?|This list seems doable; there's not a grand scheme here that we'd think of as way beyond what we might be called to accomplish. There's a simplicity here that is inviting for our growth as persons of faith and a members of the Body of Christ. We're not asked to convert vast numbers of our contemporaries, but only to be attentive to those around us.|Take "hospitality" for example. Can I be open to offering hospitality to those I meet? This sounds simple enough, but there's a lot more to it in the fast-paced world around us. It is so easy for me to refuse the person in need who approaches me and asks for a hand-out. Do I see Christ in that person? I have to conclude that I do not. With that said, I need to look to continued conversion in faith. |Multiply my little encounter and consider a more pressing issue of hospitality: the thousands who are fleeing from their homelands as refugees. Where is Christ in our response to these people? Can we even see Christ's or God's call to respond in faith, hope and love? What WOULD Jesus do?|Merciful God, help us to reflect your goodness, mercy and forgiveness in our present situations. Keep us faithful to your Word (in the Good News and in the very person of Jesus). Open us to your guidance and be with us as the very source of all life. Thank you for the opportunities to discover you in our daily lives and histories. Help us to know that YOU are the source of our freedom and that you call us to fearlessness in our living and serving with you. Thank you for approaching us and our often faltering commitment in faith. This reflection was was written by Tom Shanahan, S.J., for this date, in 2017
Nonlinear vibrations of a stroke-saturated inertial actuator
No full textProof-mass actuators are typically used to supply an external control force to a structure,for the purpose of vibration suppression. These devices comprise a proof-mass suspended in a magnetic field that is accelerated in order to provide a reaction force on the actuator casing and the structure itself. If the actuator stroke length is reached or exceeded, the proof-mass will hit the end stops, resulting in a nonlinear phenomenon known as stroke saturation. In this paper, a theoretical and experimental investigation into the actuator’s dynamical behaviour is undertaken. First, the blocked inertial force of the actuator in response to an input voltage was measured experimentally using a variety of excitation amplitudes and frequencies. An analysis was conducted in the time- and frequency-domains, and the first-order force-voltage FRF of the actuator was ascertained for each excitation amplitude. The information provided by the analysis was then used to estimate the parameters for a linear piecewise stiffness model of the actuator, in order to simulate the time-domain response. Finally, a comparison of the simulated and measured signals is conducted to establish the accuracy of the model
Property A and affine buildings
No full textYu's Property A is a non-equivariant generalisation of amenability introduced in his study of the coarse Baum Connes conjecture. In this paper we show that all affine buildings of type A2, B2 and G2 have Property A. Together with results of Guentner, Higson and Weinberger, this completes a programme to show that all affine building have Property A. In passing we use our technique to obtain a new proof for groups acting on buildings.The author was supported by EPSRC postdoctoral fellowship EP/C53171X/1.<br/
On the edge of an inverse cascade
No full textWe demonstrate that systems with a parameter-controlled inverse cascade can exhibit critical behavior for which at the critical value of the control parameter the inverse cascade stops. In many dynamical systems in nature energy is transferred to small or to large length scales by a forward or inverse cascade, respectively. In three-dimensional hydrodynamic (HD) turbulence energy cascades forward from large to small scales while in two-dimensional HD turbulence energy cascades inversely from small scales to large scales. There are some examples, however, that have a mixed behavior such as fast rotating fluids, conducting fluids in the presence of strong magnetic fields, flows in constrained geometry, and others. In these examples the injected energy cascades both forward and inversely in fractions that depend on the value of a control parameter (rotation rate/magnetic field/aspect ratio ect). In the presented work we demonstrate using the 2D-MHD model that the transition from a forward to an inverse cascade can occur by a critical transition, . In the absence of any external magnetic forcing the system reduces to hydrodynamic fluid turbulence with an inverse energy cascade. In the presence of strong magnetic forcing the system behaves as 2D-MHD turbulence with forward energy cascade. As the amplitude of the magnetic forcing is varied a critical value is met for which the energy flux towards the large scales becomes zero. Close to this point the energy flux scales as a power law with the departure from the critical point and the normalized amplitude of the fluctuations diverges. The generality of this behavior to other systems with variable inverse cascades will be discussed
Why is Africa important for the U.S. at this time? A presentation by Fr. Peter Henriot, S.J.
No full textThe political-economic reasons why Africa’s future will have significance for developments in the United States, and some moral-religious reasons why people in U.S. should consider Africa’s future to be of significance to a faith community in the U.S.|Fr. Peter Henriot, S.J. is an internationally respected Jesuit researcher, speaker and writer on Social Justice, Globalization and Africa, who came to the U.S., from his current home in Zambia, to give the keynote address: "Justice in Africa: On Whose Terms?" at the Africa Faith and Justice Network Conference, in Washington, D.C.|Fr. Peter Henriot, born in Tacoma Washington, is a member of the Zambia-Malawi Province of the Society of Jesus. He has worked in Zambia since 1989, and, since 1990, has been the director of the Jesuit Centre for Theological Reflection (JCTR) in Lusaka, Zambia. The JCTR is a project of the Zambia-Malawi Province of the Society of Jesus, founded in 1987 to assist the local church and other groups in matters of political, economic and social justice concerns, through research, education, advocacy and consultation. Their work includes studies on constitutional reform, good governance, poverty eradication, debt cancellation, education for justice, theological reflection.|From 1971 to 1988, he was part of the Center of Concern in Washington, DC, a project founded by the United States Catholic Conference and the Society of Jesus to promote study and advocacy on social issues. He served as Director from 1978 to 1988. Peter is the author of numerous articles, scholarly and popular, on socio-economic development and on church’s social teaching. He is the co-editor of The Pastoral Circle Revisited: A Critical Quest for Truth and Transformation, Orbis Books, 2005; co-author of Catholic Social Teaching: Our Best Kept Secret, Orbis Books, fourth and expanded edition, 2003. Co-author of Social Analysis: Linking Faith and Justice, Orbis Books, 1983. Author of Opting for the Poor: The Challenge for the Twenty-First Century, Center of Concern, 2004. Peter is a weekly columnist for THE POST, Zambia’s independent newspaper
Jesuit art in the Paraguay reductions - Rev. Clement J. McNaspy, S.J.
No full textRev. Clement J. McNaspy, S.J., professor, author and curator at Loyola University New Orleans, discusses the Jesuit mission in the reductions - or settlements - in Paraguay.https://digitalcommons.fairfield.edu/archives-posters/1075/thumbnail.jp
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