1,721,200 research outputs found
The latest achievements in study of tuberculosis
No full textTuberculosis is one of the leading causes of mortality and morbidity worldwide. In 2010, there were 8.8 million (range, 8.5-9.2 million) incident cases of TB, 1.1 million deaths from TB among HIV-negative people and an additional 0.35 million deaths from HIV-associated TB. Due to such health-related importance, tuberculosis is one of areas being actively researched. Many numbers of tuberculosis-related papers are being presented each year, and in this review, it summarizes contents of a few papers that had been selected among the papers presented from 2009 to early 2011. Copyright©2011. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.Y
Diagnosis and treatment of latent tuberculosis infection in Korea
No full text[No abstract available]N
Serial interferon-gamma release assays after chemoprophylaxis in a tuberculosis outbreak cohort
No full textInterferon-gamma release assay (IGRA) results have been suggested as a surrogate marker of treatment response in latent tuberculosis infection (LTBI). However, data have not been consistent, and most previous studies focused on participants taking isoniazid prophylaxis. The aim of this study was to elucidate the changes in the IGRA results in patients who underwent chemoprophylaxis with isoniazid and rifampicin daily for 3 months. In a TB outbreak cohort, 26 asymptomatic close contacts with normal chest radiographs and positive QuantiFERON-TB Gold In-Tube assay (QFT-GIT) results were recruited. These patients were treated with isoniazid and rifampicin daily for 3 months. The QFT-GIT was repeated at 3 and 6 months following treatment initiation. Compared with the initial QFT-GIT results (3.59 +/- A 3.39 IU/mL), the interferon-gamma (IFN-gamma) levels had decreased significantly at 6 months (0.84 +/- A 1.14 IU/mL; P = 0.005), but not at 3 months (3.58 +/- A 3.64 IU/mL; P = 0.98). Reversions occurred in seven (26.9 %) patients at 3 months and in an additional two participants at 6 months; a total of nine participants (34.6 %) had reversions. Recent conversion was associated with reversion of the test results (odds ratio 26.3, 95 % confidence interval 3.04-226.6). Chemoprophylaxis with isoniazid and rifampicin generally decreased IFN-gamma levels among tuberculosis contacts. However, only a small portion of participants achieved reversion.N
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