6,011 research outputs found
In Conversation with Daniel Liang
No full textIntroduction to Programming author Daniel Liang discusses how Revel Programming brings coding to life with interactives and the successful results he\u27s experienced in his own classroom
Accelerated J-resolved proton magnetic resonance spectroscopic imaging
No full text1H-MRSI has long been recognized as a powerful tool for noninvasive mapping of metabolites and neurotransmitters. A fundamental challenge of conventional 1H-MRSI is that resonances from different molecules overlap with one another in the crowded chemical shift frequency spectrum, which will lead to great difficulties in separating different resonances and accurate detection of specific molecules. J-resolved 1H-MRSI has the potential to overcome this limitation by encoding J-evolution information of different molecules thus adding another spectral dimension. The additional dimension, however, requires multiple repetitions of conventional 1H-MRSI scans with different acquisition parameters, leading to a prohibitively long scan time.
In this work, we present a novel approach to accelerating J-resolved 1HMRSI by integrating semi-LASER based signal excitation, sparse data acquisition and subspace based data processing. More specifically, we first recognize that the high-dimensional J-resolved 1H-MRSI signals reside in a lowdimensional subspace, thereby significantly reducing the degrees-of-freedom of the desired image function. Based on the subspace model, a semi-LASER J-resolved 1H-MRSI pulse sequence is developed to efficiently sample sparse and limited data, whose parameters are optimally selected according to theoretic analysis. Finally, a joint subspace model is utilized to reconstruct high-quality spatiospectral distributions of metabolites and neurotransmitters, incorporating both spatial and spectral prior information through a weighted regularization and pre-trained spectral basis. Phantom and in vivo experiments were performed to demonstrate the feasibility of the proposed method, generating impressive results. The proposed method achieved unprecedented capability of high-resolution mapping of metabolites and neurotransmitters within a clinically feasible scan time. The proposed method is expected to make high-resolution J-resolved 1H-MRSI experiments more practically useful.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-12-01The student, Yibo Zhao, accepted the attached license on 2019-11-21 at 15:21.The student, Yibo Zhao, submitted this Thesis for approval on 2019-11-21 at 15:50.This Thesis was approved for publication on 2019-11-22 at 11:03.DSpace SAF Submission Ingestion Package generated from Vireo submission #14583 on 2020-02-28 at 17:36:37Made available in DSpace on 2020-03-02T22:38:45Z (GMT). No. of bitstreams: 2
ZHAO-THESIS-2019.pdf: 1471638 bytes, checksum: 7001e1a094e84d04aad9b84e1ef9cc9f (MD5)
LICENSE.txt: 4206 bytes, checksum: 14aceb441d8aaf3bfb3fcc7f6711a13f (MD5)
Previous issue date: 2019-11-22Embargo set by: Seth Robbins for item 113996
Lift date: 2022-03-02T22:39:04Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 113996 on 2022-03-03T10:15:30Z
sj-pdf-2-imr-10.1177_03000605221139667 - Supplemental material for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing
No full textSupplemental material, sj-pdf-2-imr-10.1177_03000605221139667 for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing by Yao Lu, Liang Sun, Qian Wang, Cheng Ren, Yibo Xu, Haobo Ye, Ming Li, Hanzhong Xue, Qiang Huang, Zhong Li, Kun Zhang and Teng Ma in Journal of International Medical Research</p
Research Data for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing
No full textResearch Data for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing by Yao Lu, Liang Sun, Qian Wang, Cheng Ren, Yibo Xu, Haobo Ye, Ming Li, Hanzhong Xue, Qiang Huang, Zhong Li, Kun Zhang and Teng Ma in Journal of International Medical Research</p
Supplemental Material - A meta-analysis of the Masquelet technique and the Ilizarov bone transport method for the treatment of infected bone defects in the lower extremities
No full textSupplemental Material for A meta-analysis of the Masquelet technique and the Ilizarov bone transport method for the treatment of infected bone defects in the lower extremities by Cheng Ren, Ming Li, Teng Ma, Zhong Li, Yibo Xu, Liang Sun, Yao Lu, Qian Wang, Hanzhong Xue and Kun Zhang in Journal of Orthopaedic Surgery</p
Pulangke wei xing ce liang dui chun liang zhang liang bi li de gui fan
No full textLau, King = 普朗克衛星測量對純量-張量比例的規範 / 劉荊.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 83-89).Abstracts also in Chinese.Title from PDF title page (viewed on 15, September, 2016).Lau, King = Pulangke wei xing ce liang dui chun liang-zhang liang bi li de gui fan / Liu Jing
Liang zi guang li xue de Hamidun liang
No full textCheung, Hoi Kit = 量子光力學的哈密頓量 / 張凱傑.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 102-109).Abstracts also in Chinese.Title from PDF title page (viewed on 07, November, 2016).Cheung, Hoi Kit = Liang zi guang li xue de Hamidun liang / Zhang Kaijie
A Historical research of the Liang Chen Plan
No full textIn February 1950, Liang Sicheng and Chen Zhanxiang jointly proposed the "Proposal on the Location of the Central People's Government's Administrative Center Area", which is known as the Liang Chen Plan. Although this scheme has not been implemented, it is often mentioned. The designers have objective understandings of Beijing's urban functions, development conditions, and spatial structure. This scheme once gave Beijing the opportunity to move towards a completely different direction from now.AR2A011Architecture, Urbanism and Building Science
Zhong xin liang zi bi te dui huan jing zhong wu li liang de tan ce
No full textChen, Dongqing = 中心量子比特對環境中物理量的探測 / 陳冬青.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 100-103).Abstracts also in Chinese.Title from PDF title page (viewed on 28, October, 2016).Chen, Dongqing = Zhong xin liang zi bi te dui huan jing zhong wu li liang de tan ce / Chen Dongqing
Identification and functional analysis of anti-citrullinated protein antibodies in rheumatoid arthritis
No full textRheumatoid arthritis (RA) is a complex autoimmune disease and typically manifested by joint inflammation and bone erosion with approximately 0.5% of the global population affected. To date, it is believed that genetic predisposition (e.g. HLA-DRB1 alleles) and environment (e.g. cigarette smoking) are involved as risk factors for the development of RA. A hallmark of RA preceding the disease onset is the emergence of autoantibodies, including rheumatoid factors (RFs) and anticitrullinated protein antibodies (ACPAs). Being the most specific (>90%) and sensitive (>60%) autoantibodies in RA, ACPAs have been included in the clinical criteria for the classification of RA. The function of ACPAs in RA is still unclear. Although patients with ACPA positivity are associated with more severe arthritis and in vitro studies have shown certain pathogenic effects of ACPAs, the in vivo evidence remains lacking. On the other hand, extensive but common Nglycosylation in the variable domain of ACPAs (90%) has been unveiled, questioning if these Nglycans serve a functional role.In Study I, we expressed several monoclonal ACPAs derived from RA patients and identified their specificities using a panel of citrullinated peptides. We found one of the ACPAs, clone E4, could protect against collagen antibody induced arthritis in mice. The protection is joint-specific and depending on the interaction between E4 in complex with citrullinated alpha-enolase and FCGR2B on activated macrophages, enhancing the IL-10 secretion and supressing osteoclastogenesis by macrophages. In Study II, we focused on the variable domain glycans (VDGs) in ACPAs by employing crystallography, glycobiology and functional B cell assay. We showed that 1) VDGs are positioned in the vicinity of the paratope with an impact on the antigen-binding; 2) VDGs could enhance B cell activation, and 3) VDG-expressing B cell receptors stay longer on the cell surface. In Study III, we investigated the two most significant arthritis QTLs in inbred rats, Ncf1 and Clec4b, and showed that Ncf1 and Clec4b together modulate the severity of arthritis in rats and their expression on neutrophils modulate the production of reactive oxygen species by neutrophils.Taken together, the findings revealed a protective, rather than pathogenic effect of certain ACPAs in RA and elucidated the unique properties of VDGs in ACPAs and their functional impact on autoreactive B cells.List of scientific papersI. Yibo He, Changrong Ge, Àlex Moreno-Giró, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lönnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmström, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, René E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev & Rikard Holmdahl. A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis. Nature Communications. 14, 691 (2023). https://doi.org/10.1038/s41467-023-36257-x II. Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S.B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J.M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W.J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E.M. Toes. Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation. Science Advances. 8, eabm1759 (2022). https://doi.org/10.1126/sciadv.abm1759 III. Mike Aoun, Xiaojie Cai, Bingze Xu, Gonzalo Fernandez Lahore, Michael Yi Bonner, Yibo He, Liselotte Bäckdahl and Rikard Holmdahl. Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis. Antioxidants. 11(1): 12 (2022). https://doi.org/10.3390/antiox11010012 </p
- …
