13 research outputs found
Duration of labour and severity of postpartum haemorrhage: a case-control study
No full textBackground: Postpartum haemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, contributing significantly to adverse maternal outcomes. Hence, this study aimed to compare the duration of labour in women with and without PPH and among women having PPH with and without risk factors. Also to determine the gradient effect of duration of labour on severe PPH and maternal consequences of PPH.
Methods: A case-control study was conducted in the department of obstetrics, Fernandez hospital, Hyderabad. The required sample size was 197 cases and 397 controls (1:2 ratio) within 8 months duration.
Results: The mean age of the cases and controls were 28±3.66 and 28±3.91 years, respectively. Anaemia was more prevalent among cases (10.15%) than controls (4.03%), with a p=0.001. Hypertension was more common in controls (16.1%) than in cases (9.1%), with a p=0.02. The mode of conception differed significantly, with assisted conception being more prevalent among cases (7.6%) compared to controls (3.8%) (p=0.04). The duration of various labour stages was significantly longer in cases than in controls. Intrapartum fever was significantly higher in cases (37.06%) compared to controls (15.37%), (p≤0.001).
Conclusions: The study results indicate that longer durations of labour, the need for oxytocin augmentation, and specific maternal characteristics such as anaemia and mode of conception are significant predictors of PPH. The gradient effect of labour duration on the risk of PPH suggests that monitoring labour progression and timely intervention are crucial in preventing severe haemorrhage.
Effect of Freeze Drying on the Stability of Probiotic Lactic Acid Bacteria
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Duration of meconium-stained labor-prevalence and association with adverse maternal and neonatal outcomes
No full textBackground: Meconium-stained amniotic fluid (MSAF) is the result of the passage of fetal intestinal contents by normal intestinal peristalsis of the mature fetus or by vagal stimulation in utero. It affects up to 9-20% of deliveries. The incidence of MSAF increases with gestational age from 31 weeks to the end of pregnancy. MSAF is known to be associated with neonatal adverse effects. To provide insight on the correlation between secondary Meconium stained amniotic fluid and adverse pregnancy outcomes including maternal and neonatal morbidities, compared with Primary MSAF.
Methods: This was a prospective longitudinal observational study done at Fernandez Hospital, Hyderabad over a period of 1 year 5 months-Aug 2022 to Dec 2023. All women with Term gestation, singleton pregnancy, with spontaneous or induced labour, who were booked or referred delivering at Fernandez Hospitals and were included in this study Sample size received during study was 500.
Results: Secondary MSL was seen more to occur with Primigravida and Nulliparous women (p=0.045). Association of secondary MSL was found to be more with Induced labor whereas occurrence of Primary MSL was more seen in spontaneous labor (p=0.042). Complications such as PPH, Non-reassuring FHR were more in secondary MSL group and were statistically significant. Composite neonatal outcomes of Acidemia, low apgar at 1 min, Need for resuciation and Meconium aspiration were significant in secondary MSL Group.
Conclusions: MSAF remains a stigma. This study showed complications more with secondary MSL than Primary MSL. The findings would be useful in counselling couples in such case scenarios and make informed choices and help in decision making
Preparation and Characterization of Biodegradable Modified Chitosan Films for Food Packaging
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Role of p75 neurotrophin receptor in the development of neuronal and oligodendroglial progenitors of the rat postnatal subventricular zone
No full textThe p75 neurotrophin receptor is widely expressed in the brain during embryonic development (Frade & Barde, 1998). In neonatal and adult ages its expression in the central nervous system gets restricted to specific cell populations including cholinergic neurons of the basal forebrain, olfactory ensheathing glia, progenitors of the hippocampus and progenitors of the cerebellum where it plays a multitude of roles. While some studies have also reported that the subventricular zone (SVZ) expresses p75NTR in postnatal and adult stages (Galvão, RP, Garcea-Verdugo, JM, Alvarez-Buylla, 2008; Giuliani et al., 2004; van Strien et al., 2014; Young, Merson, et al., 2007), its exact role in this germinal niche remains unknown. Further, the expression of p75NTR has been reported at various ages in the rat and human SVZ but it is not observed in mice (Galvão, RP, Garcea-Verdugo, JM, Alvarez-Buylla, 2008). Although species differences remain unexplained, no comprehensive studies of p75NTR, regarding its role in the rat or human SVZ, have been conducted thus far. The SVZ serves as a neurogenic niche for the olfactory bulb in adult animals (Alvarez-Buylla et al., 2002; Bath & Lee, 2010; Faigle & Song, 2013). For a brief period postnatally, it also generates glial cells, predominantly oligodendrocytes for the corpus callosum, cortex and striatum (Kessaris et al., 2006.; Kuhn et al., 2019; Luskin & McDermott, 1994; Menn et al., 2006; Naruse et al., 2017). Initial characterization showed expression of p75NTR in the dorsolateral SVZ throughout postnatal development in rats with maximal expression observed during the period of gliogenesis. Therefore, I hypothesized that p75NTR may be involved in the regulation of SVZ progenitor development during postnatal development.
This study shows that p75NTR regulates both neuronal and oligodendroglial progenitors in the postnatal SVZ. Progenitors expressing p75NTR proliferate longer than cells in the dSVZ that lack p75NTR. I also determine that in the absence of p75NTR, postnatal oligodendrocyte progenitor development was accelerated in comparison to that observed under normal conditions. Consequently, I observed premature maturation of oligodendrocytes at postnatal ages which could have implications for myelination.
Furthermore, I describe a role for p75NTR in neurogenesis where p75NTR defines a specific neuronal subpopulation expressing the transcription factor Pax6. I show that, postnatally, p75NTR is expressed by proliferating cells present in the rostral migratory stream extending from the lateral ventricle to the olfactory bulb. In younger animals, absence of p75NTR did not alter the cytoarchitecture of the olfactory bulb and did not affect odor discrimination. However, lack of p75NTR functionally affected odor discrimination in aged rats and led to changes in the olfactory bulb circuitry.
Overall, this study defines a novel role for the multifunctional receptor p75NTR in the SVZ in regulation of oligodendrocyte progenitors in vivo during postnatal development. Further, I provide evidence that the role of p75NTR is not limited to a single subset of oligodendrocyte lineage committed progenitors but could have additional roles in olfactory bulb neurogenesis as a result of ageing.Ph.D.Includes bibliographical reference
Author Correction: Highly dampened blood transcriptome response in HIV patients after respiratory infection
No full textCorrection to "Highly dampened blood transcriptome response in HIV patients after respiratory infection
Author Correction: Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly
No full textThe original article [1] contained an error in Fig. 3 and omitted a Funding source which the authors would like to correct. Due to a labeling error in one of our Iso-Seq samples, the RNA sample that was collected 24h after blood feeding was labeled as 324 by the sequencing center because they unknowingly removed a separator between the replicate number and the sample name. The error resulted in a different ordering of categories than we would have chosen, though this doesn’t actually affect the interpretations we made in the manuscript. The corrected Fig. 3 can be viewed ahead in this correction article. Although the error does not affect any conclusion, it remains technically inaccurate and merits correction. We also did not acknowledge funding from the United States National Science Foundation (NSF) to J.J.E. for development of the sex chromosome inference approach. This is an important oversight, as NSF requires acknowledgment. The grant number is: NSF grant IOS-1656260
Data extracted from articles for meta-analysis.
No full textData included author details, year of publication, marker, Pubmed ID and case number both in Non-Dysplastic Oral Lesions (ND-OL) and Dysplastic Oral Potentially Malignant Disorders (D-OPMD). (DOCX)</p
