36,671 research outputs found
Rethinking Import-substituting Industrialization: Development Strategies and Institutions in Taiwan and China
Get PDFimport-substituting industrialization, export-oriented industrialization, development strategies, institutions
Dissociation of posture remapping and cognitive load in level-2 perspective-taking: Raw data of three experiments
No full textYeh, Yei-Yu, Wang, Chi-Chin, Cheng, Shih-kuen, & Chiu, Chui-De. (in press). Dissociation of posture remapping and cognitive load in level-2 perspective-taking. Cognition
The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways
No full textCopyright © 2009 Elsevier Ltd All rights reserved.Mei-Chi Chang, Li-Deh Lin, Chiu-Po Chan, Hsiao-Hua Chang, Lin-I. Chen, Hsueh-Jen Lin, Hung-Wei Yeh, Wan-Yu Tseng, Po-Shuen Lin, Chiu-Chun Lin and Jiiang-Huei Jenghttp://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#descriptio
Social patterns of pay systems and their associations with psychosocial job characteristics and burnout among paid employees in Taiwan
No full textWan-Ting Yeh: Caregiver and Infant Speech Matters: An acoustic analysis on joint engagement during caregiver-infant peekaboo play in different digital contexts
No full textCaregiver-infant cooperative interactions, such as peek-a-boo, are foundational to development. Verbal cues characteristic of peek-a-boo are well-documented in traditional contexts, but how these cues change across digital device contexts remains unknown. Understanding the influence of digital devices is key to identifying how to preserve cooperative interactions in our digital worldThis poster was uploaded for the SGS Research Showcase 2022.
Choose your favourite poster for the SGS Research Showcase People's Choice Award: Academic Poster category.</p
The Cross Influence between Japanese Poetry(Ho-K’o) and Han Poetry- Take the Thirty-third Pair Poetry of the New Composed Wan-Yeh Collection as Example
No full textThe poetry anthology, New Composed Wan-Yeh Collection which contained both Ho-K’o & Han-Shih, appeared in the early days of P’ing-An (893 AD). It was after Wan-Yeh Collection, & a little earlier than the official-edited Ho-K’o collection that was Ancient & Contemporary Ho-K’o Collection (905 AD). The anthology was marked as Wan-Yeh, & classified in volumes according to spring, summer, autumn, winter & love. Therefore each volume was arranged to have a Ho-K’o & a Han-Shih to form a pair. This dissertation tries to use the thirty-third pair of poems as an example to collate the exchanges in the early days of P’ing-An, by the criticism of the charts, & the analysis of & the comparison between Ho-K’o & Han-Shih
Non-steroidal anti-inflammatory drugs and the risk of first occurrence of heart failure
No full text背景：目前研究指出，在曾經因為心衰竭住院的病人身上使用非類固醇消炎止痛藥(Non-steroidal anti-inflammatory drugs, NSAID)，會增加病人再次因心衰竭住院的風險，也增加病人的死亡率。但在還未發生心衰竭的病人身上使用非類固醇消炎止痛藥，是否也增加病人發生心衰竭的風險，過去的文獻沒有一致的結論。
研究目的: 探討一般族群使用非類固醇消炎止痛藥(包括 non-selective NSAID與COX-2 inhibitor)是否增加新發生心衰竭的風險。
研究方法：以台灣健保資料庫2005年國衛院百萬人抽樣歸人檔為資料來源，選取2004-2007年間第一次因心衰竭住院，或第一次在門診診斷心衰竭的個案，以病例交叉研究設計方式分析。定義第一次因心衰竭住院的就診日期，或是第一次在門診診斷心衰竭的就診日期，為心衰竭發生日(index date)。選取心衰竭發生日(index date)前30天為病例期(case period)，心衰竭發生日(index date)前90-120天為對照期(control period)，比較病例期與對照期非選擇性非類固醇消炎止痛藥(non-selective NSAID)與選擇性非類固醇消炎止痛藥(COX- 2 inhibitor ,celecoxib)的暴露是否有差異。使用conditional logistic regression做分析，估算NSAID藥物使用與心衰竭風險之勝算比(OR)和95%信賴區間。並在multivariable analysis中控制病例期與對照期間不一致的干擾藥物使用( discordant pair of potential confounding drugs)。
結果：總共有5053位病人納入分析，女性比例約53%，年齡分布以60歲以上族群為多(80%)。在研究藥物使用與心衰竭風險的勝算比估算方面，發現使用non-selective NSAID會顯著增加心衰竭的風險，風險約為1.4倍(95% CI 1.25-1.57)，其中高劑量使用時期(>1DDD/day)較中低劑量使用時期(1DDD/day) 較中低劑量使用時期(<1DDD/day)有風險增高趨勢，但未達統計顯著性。 年齡別、性別不影響使用non-selective NSAID/celecoxib對心衰竭風險的勝算比。但新使用者(new user)或長期使用者(prevalent user)會影響使用non-selective NSAID/celecoxib對心衰竭風險的勝算比，達統計顯著性，其中新使用者(new user)有較高風險: non-selective NSAID的新使用者，心衰竭風險為4.64倍(95%CI 3.00-7.17)；celecoxib的新使用者，心衰竭風險為3.53倍(95%CI 1.19-10.50)。在個別藥物分析部分，使用口服etodolac, nimesulide, meloxicam, diclofenac之心衰竭風險顯著增加，分別為1.98至1.33倍不等。使用口服ketorolac, piroxicam, flurbiprofen, mefenamic acid, ibuprofen有增加心衰竭風險的趨勢，但未達統計顯著性，其風險分別為1.61至1.22不等。使用口服Indometacin, sulindac, acemetacin, naproxen, ketoprofen則未明顯增加心衰竭風險。在注射藥物分析部分，ketorolac增加心衰竭風險，達統計顯著性。Diclofenac有增加心衰竭風險趨勢，但未達統計顯著性。Ketoprofen未明顯增加心衰竭風險。比較三種藥物口服劑型與注射劑型之效果，皆呈現一致的方向，且注射劑型似乎較口服劑型風險更高。敏感性分析部分，改變定義心衰竭發生日期(提前1或2周)，改變對照期選取(index date前60-90天)，改變時間窗長度為14天，結果均呈穩定狀態(robust) 。
結論： 本篇研究發現使用non-selective NSAID會顯著增加心衰竭風險，且有劑量效應。高劑量使用時期與新使用者(new user)有更高風險。不同種類non-selective NSAID有不同危險性，其中口服藥etodolac, nimesulide, meloxicam, diclofenac與注射藥ketorolac的使用顯著增加心衰竭風險。Celecoxib的使用在本研究中有增加心衰竭風險的趨勢，但未達統計顯著性，因celecoxib使用個案數少，需要後續研究探討。
根據本研究結果，建議醫師在開立non-selective NSAID之前，應做心衰竭之風險評估，並且在使用過程中密集監控病人是否出現早期心衰竭症狀，尤其是高劑量使用時期或新使用者。在做藥物選擇時，也可參考不同藥物的相對風險，選擇相對安全的藥物
Somatic mutations in epidermal growth factor receptor underlying complete responsiveness to gefitinib in a taiwanese female patient with metastatic adenocarcinoma of lung.
No full textObstacle crossing in 7-9-year-old children with Down syndrome
No full textThis study aimed to investigate obstacle crossing in 7-9-year-old children with Down syndrome (DS). Fifteen children with DS, age- and gender-matched with 15 typically developing (TD) children, were recruited to walk and cross obstacles with heights of 10%, 20% and 30% of their leg lengths. End-point and kinematic variables of obstacle crossing were obtained using a three-dimensional motion analysis system. The results showed that children with DS tend to adopt a lower speed and larger step width when they perceive instability. Moreover, unlike TD children, children with DS adopt a pelvic strategy (i.e., greater pelvic leading-side listing and forward rotation) to achieve a higher leading toe clearance with a longer step length, presumably for safety reasons. This pelvic strategy increased the frontal plane motion of the whole leg and trunk, and thus possibly stability, during obstacle crossing. However, this strategy may be inefficient. Trailing toe clearance did not differ significantly between two groups. The results of this study suggest that children with DS tend to use inefficient and conservative strategies for obstacle crossing. Knowledge of both end-point and kinematic control of obstacle crossing in children with DS is useful for understanding the mechanisms of obstacle-related falls. Moreover, obstacle crossing can be used as a task-oriented rehabilitation program for children with DS. (C) 2015 Elsevier Ltd. All rights reserved
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