2,669 research outputs found
Natural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
Spatial and temporal distributions of sailfish associated with environmental factors in the Northwestern Pacific Ocean
No full textCorrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Towards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
Nucle J. Biol. Chem.ophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.
No full textHybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
No full textWaste and innovation. How waste companies and government can interact to stimulate innovation in the Dutch waste industry
No full textThis thesis answers the question how government and Dutch waste companies can interact in such a way that innovation is stimulated. The author has developed a method to determine the potential for self-regulation and self-control of a company or an industry. This method is based upon the measurement of degree to which the company has assured legal compliance within the own organisation. Furthermore an approach is given to create innovation-friendly regulation using innovation theoretical principles.Industrial Design Engineerin
On the performance of densified DVB-H single frequency networks
No full textThe broadcasting of TV programmes to mobile phones can be enabled by the newly developed technology called Digital Video Broadcasting-Handheld (DVB-H). Because of the scarcity and cost of frequency resources, frequency reuse needs to be considered when rolling out DVB-H networks. By simulcasting the same content from several transmitters, a Single Frequency Network (SFN) can provide good coverage and good frequency efficiency. In this paper, the performance of densified DVB-H SFN networks is analysed in terms of the coverage probability under different coverage requirements with and without frequency reuse. A dichotomy searching approach is used to determine the optimal cell radius for a cell in a densified DVB-H SFN for a given network topology. Based on the optimal cell radius map and a SFN gain map generated from the simulation results, guidelines are proposed on how to avoid the potential pitfalls in configuring the parameters of a densified DVB-H SFN network and optimise its parameters in terms of minimising the cost of the network for a range of predefined network parameters
Policy analysis of water management for the Netherlands. Vol VII: Assessment of impacts on drinking-water companies and their customers
No full textThis volume assesses the impacts of a number of water management policies developed by PAWN on drinking-water (DW) companies and their customers (households, commercial entities, and industrial firms). Chapter 2 summarizes briefly the major water-related problems facing DW companies in the Netherlands today, and shows why the author believes they will become more severe in the future. Chapter 3 describes the methodology in detail. Chapter 4 presents the impacts and associated discussion of PAWN's primary and groundwater cases on DW production, and on DW companies and their customers. Finally, in Chap. 5, the author assesses those impacts, draws some overall conclusions, and discusses the implications of those conclusions for the future supply and costs of DW in the Netherlands.PAW
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