86,361 research outputs found

    Say et al. Clinical Nutrition Online Supplementary Data

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    This is the online supplementary data for the manuscript Say et al. Golgin A Family Member B (GOLGA7B) is a plausible novel gene associating high glycaemic index diet with acne vulgaris. The full lists of the DEGs in each filtering step in Figure 1 are listed in this data

    How Do You Say No?

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    Have you ever found yourself thinking: “I know I said yes to this, but now I wish I’d said no. That’s what I wanted to say in the first place”? Chances are you said yes because you were afraid to say no or you didn’t know how, or you don’t like saying no. If you [...

    How to write what you want to say ... about visual images

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    This guide provides students of all subjects with the language that they need to write about a variety of visual images. It gives inexperienced writers a starting point to say what they want to say using language that mature writers use. How to write what you want to say... about visual images is a guide for those who know what they want to say but can’t find the words. It is unique in providing the tools for writing about the full range of visual images, including those used to inform (such as graphs, diagrams and maps) and those that tell a story or appeal to the emotions (such as artworks, photographs and sketches and illustrations). It suits inexperienced writers from the middle years of schooling onwards

    Ways to Talk & Yet Say Nothing or Ways to Not Talk & Yet Say Everything

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    'Ways to Talk & Yet Say Nothing, or Ways to Not Talk & Yet Say Everything' is a limited edition publication created in collaboration with the Women's Studio Workshop, New York, USA. It is a development of ideas created as part of a project called 'The Architecture of Conversation'.\ud \ud 'Ways to Talk & Yet Say Nothing, or Ways to Not Talk & Yet Say Everything' brings together a weaving of theory and practice exploring the history, symbolism and usage of the speech balloon. Various print techniques are utilised to examine how we speak.\ud \ud The book comprises a custom-made bound folio containing a set of nine prints, with inset letterpressed pamphlet.\ud \ud Hand-made and printed in an edition of 50, using silkscreen, letterpress, intaglio and laser-cut

    PA SHT98 Paper Raw Data YHSay

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    Raw data for the paper "Palmitic acid induces neurotoxicity and gliatoxicity in SH-SY5Y human neuroblastoma and T98G human glioblastoma cells" </b

    Say it in Six (or less)

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    Lightning talk introducing Ron Hoff's book, "Say it in Six: How to Say Exactly What You Mean in Six Minutes or Less" as adapted during ACRL's Immersion 2017 by A. Barhart, Cunninham, and L Hinchliffe

    The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

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    Abstract Background Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance—collectively known as metabolic syndrome). Hence, this paper reviews the types of INDELs and VNTRs that have been studied for association with obesity and its related traits and complications. Main body of the abstract These INDELs and VNTRs could be found in the obesity loci or genes from the earliest GWAS and candidate gene association studies, like FTO, genes in the leptin–proopiomelanocortin pathway, and UCP2/3. Given the important role of the brain serotonergic and dopaminergic reward system in obesity susceptibility, the association of INDELs and VNTRs in these neurotransmitters’ metabolism and transport genes with obesity is also reviewed. Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations. As obesity results in chronic low-grade inflammation of the adipose tissue, the proinflammatory cytokine gene IL1RA and anti-inflammatory cytokine gene IL4 have VNTRs that are implicated in obesity. A systemic proinflammatory state in combination with activation of the renin–angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction. This explains why VNTR and INDEL in eNOS and ACE, respectively, could be predisposing factors of obesity. Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity. Short conclusion In conclusion, INDELs and VNTRs could have important functional consequences in the pathophysiology of obesity, and research on them should be continued to facilitate obesity prediction, prevention, and treatment

    How to say ‘sorry’ on social media

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    Must the old and new always be in conflict? The rise of self-proclaimed arbiters of justice on social media need not imply that the ideas of apologies and forgiveness be consigned to the history books. They are perhaps the most effective conflict resolution mechanism we have. And they will likely have to be part of the evolution of social media

    La recepción de la obra de Jean-Baptiste Say en España: la teoría económica del empresario

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    Este trabajo analiza la difusión de la teoría del empresario de Jean-Baptiste Say en España, como último eslabón de una línea de pensamiento que tiene su origen en Richard Cantillon. Se prueba que la particularidad de este autor es su gran difusión en el siglo XIX español –siendo uno de los más traducidos– y la escasa influencia de su teoría económica del empresario. Explicamos las razones de una paradoja que deja sin fundamentos teóricos a cualquier política económica destinada al desarrollo del tejido empresarial nacional. Son presentados los mecanismos de difusión, tanto directos, por medio de traducciones, como indirectos, por medio de autores españoles que pudieron difundir esta teoría de la función empresarial. Nos interesa conocer la recepción por parte de los autores españoles de la teoría del empresario de Say, determinar su grado de comprensión, de interpretación en relación con la realidad nacional, de revisión teórica, e incluso conocer si la fuente real de la idea a transmitir es el propio autor o alguna otra.This paper illustrates the spread of Jean-Baptiste Say’s entrepreneur theory in Spain –a last contribution within the French tradition in which Richard Cantillon and A. R. J. Turgot were predecessors. We attempt to demonstrate that this is a special case, because, even though J. B. Say was the most important author from a publishing point of view, his economic theory of entrepreneurship had very little influence. The spread of economic ideas by way of translation and Spanish authors which employed J. B. Say’s economic theory, give possible explanations to a paradox which had left economic policy without a theoretical reference. We analyse how Say’s entrepreneur theory was received among Spanish authors in the 19th century, its degree of comprehension and the analytical additions made, and attempt to identify the real source of transmission
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