134 research outputs found
Supplemental Material, sj-tiff-1-cpt-10.1177_10742484221074585 - The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity
No full textSupplemental Material, sj-tiff-1-cpt-10.1177_10742484221074585 for The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity by David Yardeni, Ronen Toledano, Victor Novack, Aryeh Shalev, Arik Wolak, Yaron Rotman and Ohad Etzion in Journal of Cardiovascular Pharmacology and Therapeutics</p
Supplemental Material, sj-tiff-2-cpt-10.1177_10742484221074585 - The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity
No full textSupplemental Material, sj-tiff-2-cpt-10.1177_10742484221074585 for The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity by David Yardeni, Ronen Toledano, Victor Novack, Aryeh Shalev, Arik Wolak, Yaron Rotman and Ohad Etzion in Journal of Cardiovascular Pharmacology and Therapeutics</p
Designing and design thinking in strategy concepts: frameworks towards an intervention tool
No full text
The “Fusion” of law and equity?: A Canadian perspective on the substantive, jurisdictional, or non-fusion of legal and equitable matters
No full textEquity, in its broad understanding, has long been a fundamental part of law. Its history may be traced through principles illustrated in the Old Testament and, in
various formulations, through Ancient Greek and Roman legal constructs, as well as in Natural Law and Canon Law. While the historic presence of equity within various systems of law is unquestioned, the jurisdiction of equity within contemporary legal systems has been a matter of significant debate and confusion. Facilitating a better understanding of the contemporary role of equity requires knowledge of its meaning and the implications of the historic merger of legal and equitable jurisdictions. This paper establishes a framework for appreciating the contemporary challenges faced by equity by examining the Supreme Court of Canada’s analysis of the merger of legal and equitable jurisdictions in two major cases involving allegations of breaches of fiduciary duty: Canson Enterprises Ltd v Boughton & Co and Hodgkinson v Simms. The inconsistent application of equitable principles in these cases demonstrates the court’s confusion over the effects of the historic merger of law and equity and offers a valuable perspective for the administration of justice in contemporary law.Peer reviewe
Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
No full textGiven the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD), the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD is weight loss, it is hard to maintain, prompting the need for pharmacotherapy as well. A greater understanding of disease pathogenesis in recent years was followed by development of new classes of medications, as well as potential repurposing of currently available agents. NAFLD therapies target four main pathways. The dominant approach is targeting hepatic fat accumulation and the resultant metabolic stress. Medications in this group include peroxisome proliferator-activator receptor agonists (eg, pioglitazone, elafibranor, saroglitazar), medications targeting the bile acid-farnesoid X receptor axis (obeticholic acid), inhibitors of de novo lipogenesis (aramchol, NDI-010976), incretins (liraglutide) and fibroblast growth factor (FGF)-21 or FGF-19 analogues. A second approach is targeting the oxidative stress, inflammation and injury that follow the metabolic stress. Medications from this group include antioxidants (vitamin E), medications with a target in the tumour necrosis factor α pathway (emricasan, pentoxifylline) and immune modulators (amlexanox, cenicriviroc). A third group has a target in the gut, including antiobesity agents such as orlistat or gut microbiome modulators (IMM-124e, faecal microbial transplant, solithromycin). Finally, as the ongoing injury leads to fibrosis, the harbinger of liver-related morbidity and mortality, antifibrotics (simtuzumab and GR-MD-02) will be an important element of therapy. It is very likely that in the next few years several medications will be available to clinicians treating patients with NAFLD across the entire spectrum of disease
The “Fusion” of Law and Equity?: A Canadian Perspective on the Substantive, Jurisdictional, or Non-Fusion of Legal and Equitable Matters
No full textEquity, in its broad understanding, has long been a fundamental part of law. Its
history may be traced through principles illustrated in the Old Testament and, in
various formulations, through Ancient Greek and Roman legal constructs, as well as
in Natural Law and Canon Law. While the historic presence of equity within various
systems of law is unquestioned, the jurisdiction of equity within contemporary legal
systems has been a matter of significant debate and confusion. Facilitating a better
understanding of the contemporary role of equity requires knowledge of its meaning and
the implications of the historic merger of legal and equitable jurisdictions. This paper
establishes a framework for appreciating the contemporary challenges faced by equity by
examining the Supreme Court of Canada’s analysis of the merger of legal and equitable
jurisdictions in two major cases involving allegations of breaches of fiduciary duty:
Canson Enterprises Ltd v Boughton & Co and Hodgkinson v Simms. The inconsistent
application of equitable principles in these cases demonstrates the court’s confusion over
the effects of the historic merger of law and equity and offers a valuable perspective for
the administration of justice in contemporary lawPeer reviewe
Pioglitazone for the treatment of NASH in patients with prediabetes or type 2 diabetes mellitus—authors' response
No full text- …
