2 research outputs found
Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients
No full textBackground. Many drugs are commercially available for use in the management of diabetes. However, their side effects and high costs underscore the need for herbal alternative drugs. Trigonella foenum-graecum is one of the medicinal plants which are important in the management of diabetes mellitus. This study investigated the effect of Trigonella foenum-graecum seed powder solution on the lipid profile of newly diagnosed type II diabetic patients. Methods. A total of N=114 newly diagnosed type II diabetic patients without any significant diabetes complication were selected. They were grouped into two groups: the treatment group (n=57) consumed 25 g Trigonella foenum-graecum seed powder solution orally twice a day for one month and the second group is the control (n=57) which receives metformin. Blood sample was collected from each participant by a medical technologist/technician before and after the study. Lipid profile was analyzed by using Mindray BS 200E fully automated clinical chemistry analyzer. Result. By the end of the intervention period, the treatment group showed significantly lower total cholesterol level by 13.6% as compared with the baseline level (219.1±35.51 vs. 189.29±29.06, P<0.001) and the control group (189.29±29.06 vs. 208.2±40.2, P<0.001); triglyceride level also reduced by 23.53% compared with the baseline level (256.1±15.4 vs. 195.8±82.95, P<0.001) and compared with the control group (195.8±82.95 vs. 244.1±96.9, P<0.05); and low-density lipoprotein cholesterol level also reduced by 23.4% as compared to the baseline level (137.9±26.9 vs. 105.6±24.2, P<0.001) and the control group (between groups) (105.6±24.2 vs. 144.1±23.3, P<0.001), but the treatment group showed significantly increased high-density lipoprotein cholesterol level by 21.7% as compared to the baseline level, within group (37.8±1.51 vs. 48.3±11.9, P<0.001), and the control group, between groups (48.3±11.9 vs. 36.01±9.5, P<0.001). However, lipid profile levels in the control group were not significantly changed. Conclusion. The present study showed that the administration of Trigonella foenum-graecum seed powder solution had pronounced effects in improving lipid metabolism in type II diabetic patients with no adverse effects. Therefore, Trigonella foenum-graecum seed may provide new alternatives for the clinical management of type II diabetes
Regulación de los niveles de glucosa mediante la inducción de extracto acuoso de Pseudoelephantopus spicatus.
No full textCurrently, the field of phytopharmacology has demonstrated the antidiabetic potential of several traditional plants, among which is the Pseudoelephantopus spicatus, whose studies demonstrating its hypoglycemic effect are little known. For this reason in the present study its glycemic regulating effect was evaluated in a rat model. The experiments were carried out as a pilot test and validated in the kinetics of 0, 1, 2, 6, and 24 hours by means of five experimental groups (control, diabetics induced with alloxan, diabetics treated with metformin, and diabetics treated with Pseudoelephantopus spicatus extract with doses of 250 and 500 mg/kg). The treatments were applied for 1, 5, and 21 days. The results show that alloxan at 120 mg/kg induced Diabetes mellitus in 100% of the rats. The extract at 250 and 500 mg/kg achieved a significant reduction in blood glucose levels compared to diabetic rats, without showing significant differences between doses. The reduction of blood glucose levels caused by metformin at 500 mg/kg and the different doses of the extract did not show significant differences. According to the study findings, Pseudoelephantopus spicatus extract induces a hypoglycemic effect in rats.En la actualidad, el campo de la fitofarmacología ha demostrado el potencial antidiabético de varias plantas tradicionales, entre las que se encuentra el Pseudoelephantopus spicatus, sin embargo los estudios que demuestran el efecto hipoglucemiante de esta planata son poco conocidos. Por ello, en el presente estudio se evaluó su efecto regulador de la glicemia en un modelo de rata. Los experimentos se realizaron como prueba piloto y se validaron en una cinética de 0, 1, 2, 6 y 24 horas mediante cinco grupos experimentales (control, diabéticos inducidos con alloxan, diabéticos tratados con metformina y diabéticos tratados con extracto de Pseudoelephantopus spicatus con dosis de 250 y 500 mg/kg). Los tratamientos se aplicaron durante 1, 5 y 21 días. Los resultados demostraron que el alloxan a 120 mg/kg indujo la diabetes mellitus en el 100% de las ratas. El extracto a 250 y 500 mg/kg logró una reducción significativa de los niveles de glucosa en sangre en comparación con las ratas diabéticas, sin mostrar diferencias significativas entre las dosis. La reducción de los niveles de glucosa en sangre provocada por la metformina a 500 mg/kg y las distintas dosis del extracto no mostraron diferencias significativas. Según los resultados del estudio, el extracto de Pseudoelephantopus spicatus induce un efecto hipoglucémico en las ratas
