111,009 research outputs found

    Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

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    Chronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD

    A diluent for prolonged motility of ocean pout (Macrozoarces americanus L.) sperm

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    The present study describes a new semen diluent (diluent C) which prolongs the sustained motility of ocean pout sperm, a distinguishing feature of the sperm of internally fertilizing teleosts. Sperm motilities were compared in the new diluent (C), based on the ionic composition of ocean pout seminal plasma, vs. four other semen diluents (A, B, D and E) ordinarily used for extending the semen of external fertilizers. While sperm retained motility after extension of ocean pout semen in all of these diluents, motility was significantly reduced following sperm resuspension in diluents B and D. Since sperm motility remained high in diluent C, formulated to closely mimic the composition of ocean pout seminal plasma, it was selected for additional experimentation. Negative effects were observed on sperm motility after dilution (> 1:10) of ocean pout semen with diluent C, but sperm motility could be restored by replacement of the seminal plasma. Of practical importance for storage of ocean pout sperm at 4 degrees C, it was shown that semen dilution 1:3 in diluent C preserved sperm motility beyond 5 days. Although ocean pout sperm tolerate a fairly wide range of K+ levels (0-30 mmol/l), the best motility was observed from 10-20 mmol/l [K+], similar to the ionic levels found in seminal plasma. Finally, since no change in fertility of ocean pout sperm occurred following 1:3 dilution of semen in diluent C, we conclude that diluent C is an effective medium for in vitro artificial egg insemination and prolonged motility of ocean pout sperm. (C) 1999 Elsevier Science B.V. All rights reserved.PT: J; CR: BAYNES SM, 1981, J FISH BIOL, V19, P259 BILLARD R, 1992, J EXP ZOOL, V261, P122 BILLARD R, 1993, AQUAT LIVING RESOUR, V6, P67 CHAMBEYRON F, 1990, AQUACULTURE, V90, P345 CHAUVAUD L, 1995, ENVIRON BIOL FISH, V43, P341 COBB JLS, 1973, J FISH BIOL, V5, P587 ERDAHL AW, 1987, AQUACULTURE, V60, P311 ERDAHL AW, 1987, AQUACULTURE, V60, P323 GALLANT RK, 1993, THERIOGENOLOGY, V40, P479 GATTI JL, 1990, J CELL PHYSIOL, V143, P546 GOODALL JA, 1989, AQUACULTURE, V77, P243 OHTA H, 1996, AQUACULTURE, V142, P107 PAVLOV DA, 1994, AQUACULTURE, V122, P295 STOSS J, 1983, AQUACULTURE, V30, P229 SUQUET M, 1993, J FISH BIOL, V42, P509 WANG Z, 1997, FISH PHYSIOL BIOCHEM, V16, P77 YAO Z, 1995, MOL REPROD DEV, V42, P58 YAO Z, 1995, P 5 INT S REPR PHYS YAO ZX, 1995, AQUACULTURE, V130, P361 YAO ZX, 1995, J FISH BIOL, V47, P171; NR: 20; TC: 6; J9: AQUACULTURE; PG: 11; GA: 182MLSource type: Electronic(1

    Meet Yao Junwei, sub-manager

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    This is the third installment of my series devoted to the the Consolidated National Advertising Co, one of the largest Chinese advertising agencies established in Republican China (f.1930).  In the previous article, we introduced Zheng Yaonan, general manager of the advertising agency Consolidated National Advertising Co. In this article, we will introduce the submanager of the company, Yao Junwei.  Yao Junwei 姚君偉 (Yao Chunwei) was one of the key founders of the Consolidated National Advertis..

    Gaeana cheni CHOU & YAO 1985

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    Gaeana cheni CHOU & YAO, 1985. Especímenes: ­ Tailandia (MEL­ 445914, 1 macho en Colección Museo Entomológico de León).Published as part of Maes, Jean-Michel, Moulds, Max & Sanborn, Allen F., 2012, Cicadidae (Homoptera) de Nicaragua: Catalogo ilustrado, incluyendo especies exóticas del Museo Entomológico de Leon, pp. 1-138 in Revista Nicaraguense de Entomologia 72 on page 116, DOI: 10.5281/zenodo.826360

    Ambragaeana ambra CHOU & YAO 1985

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    Ambragaeana ambra CHOU & YAO, 1985. Especímenes: ­ Tailandia, sin más datos (MEL­ 445924, 1 macho en Colección Museo Entomológico de León).Published as part of Maes, Jean-Michel, Moulds, Max & Sanborn, Allen F., 2012, Cicadidae (Homoptera) de Nicaragua: Catalogo ilustrado, incluyendo especies exóticas del Museo Entomológico de Leon, pp. 1-138 in Revista Nicaraguense de Entomologia 72 on page 95, DOI: 10.5281/zenodo.826360

    Belisana xiangensis Yao & Li, 2013, sp. nov.

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    Belisana xiangensis sp. nov. Figs 22 –24, 41 Type material. Holotype: Male (IZCAS), Tham Xiang [18 ° 54.550 ′N, 102 ° 26.527 ′E, alt. 270 m], 1.54 km south of Vieng keo Village, Vang Vieng District, Vien Tiane, Laos, 3 December 2012, leg. Z. Yao (Yao-LA 086). Paratypes: 1 male and 2 females (IZCAS), same data as holotype. Etymology. The specific name refers to the type locality; adjective. Diagnosis. The species resembles B. leuser (Huber 2005 a: 62, figs 376–394), but can be distinguished by different shape of distal apophyses of male chelicerae (Figs 23 D and 24 C), small membranous flap (Figs 22 B and 24 B) and different position of pockets (Figs 23 A and 24 D). Description. Male (holotype): Total length 1.47 (1.56 with clypeus), prosoma 0.56 long, 0.63 wide, opisthosoma 0.91 long, 0.75 wide. Legs I, II and IV lost, leg III: 6.76 (1.95 + 0.25 + 1.60 + 2.41 + 0.55). Habitus as in Fig. 23 E. Dorsal shield of prosoma and sternum whitish, without marks; ocular area with indistinct dark marks. Leg III yellowish, without darker rings. Opisthosoma yellowish, without spots. Distance PME-PME 0.11, diameter PME 0.07, distance PME-ALE 0.01, AME absent. Ocular area not elevated. Thoracic furrow absent. Sternum wider than long (0.50 / 0.44). Chelicerae as in Figs 23 D and 24 C, with a pair of thumb-shaped apophyses proximally and a pair of long, curved apophyses distally (distance between tips: 0.28). Pedipalpi as in Figs 22 A–B and 24 A–B; trochanter with a short retrolatero-ventral apophysis; femur with a dorsal apophysis; procursus simple proximally but complex distally, with a membranous flap retrolaterally and a bent spine; bulb with a hooked apophysis and a simple embolus. Variation: Total length in another male: 1.47 (1.57 with clypeus); leg I lost. Female: Similar to male, habitus as in Figs 23 F–G. One of the specimens measured: Total length 1.69 (1.78 with clypeus), prosoma 0.59 long, 0.63 wide, opisthosoma 1.10 long, 0.73 wide; tibia I: 3.27 (leg I lost in another specimen). Distance PME-PME 0.12, diameter PME 0.08, distance PME-ALE 0.01, AME absent. Epigynum (Figs 23 A and 24 D) simple and flat externally, with dark internal shade and a pair of pockets 0.29 apart. Vulva (Figs 23 B and 24 E) with a wavy arch anteriorly and a pair of long, narrow pore plates. Retrolateral trichobothrium of tibia I at 18 %; most hairs lost on legs. Distribution. Known only from the type locality (Fig. 41).Published as part of Yao, Zhiyuan & Li, Shuqiang, 2013, New and little known pholcid spiders (Araneae: Pholcidae) from Laos, pp. 1-51 in Zootaxa 3709 (1) on page 27, DOI: 10.11646/zootaxa.3709.1.1, http://zenodo.org/record/24883
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