10,846 research outputs found
Stability data of IMB-YH-4py5-2H in rat plasma (n = 6).
No full textStability data of IMB-YH-4py5-2H in rat plasma (n = 6).</p
Metabolism of IMB-YH-4py5-2H in HLMs and with each CYP enzyme (n = 3).
No full textMetabolism of IMB-YH-4py5-2H in HLMs and with each CYP enzyme (n = 3).</p
Precision and accuracy of IMB-YH-4py5-2H in rat plasma.
No full textPrecision and accuracy of IMB-YH-4py5-2H in rat plasma.</p
Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study - Fig 1
No full textChemical structures of YH-8 (A), IMB-YH-4py5-2H (B) and IS (C).</p
UBET ANALYSIS OF ROLL TORQUE AND PROFILE FORMATION DURING THE PROFILE RING-ROLLING OF RINGS HAVING RECTANGULAR PROTRUSIONS
No full textAn analytical method using the upper-bound elemental technique is proposed for the simulation of roll torque and profile formation during profile ring-rolling. The plastic flow of material during rolling is described by dividing the whole deforming region at the roll gap into simple elements of rectangular cross-section and a kinematically admissible velocity field for the three-dimensional material flow in a typical element is derived. Comparing with the experimental results, the calculated torque estimation shows good agreement, but the prediction of geometrical change is not so satisfactory for some cases. As an engineering tool for theoretical analysis, the present method can be applied effectively to the profile ring-rolling process
Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study - Fig 2
No full textRepresentative LC-MS/MS chromatograms of IMB-YH-4py5-2H (upper row) and the IS (bottom row). Blank rat plasma (A, D); blank plasma spiked with 100 ng/mL IMB-YH-4py5-2H and 10 ng/mL IS (B, E); plasma sample collected 0.5 h following the oral administration of 100 mg/kg IMB-YH-4py5-2H (C, F).</p
Finite element modelling of the high-velocity impact forging process by the explicit time integration method
No full textThe numerical simulations of the high-velocity impact forging processes are described in this paper. The explicit time integration finite element method was used to compute the deformation of the workpiece and the dies. In order to consider the effects of strain hardening, strain rate hardening and thermal softening, which are frequently observed in high-velocity deformation phenomena, the Johnson-Cook yield surface model was applied Through the copper blow test simulation, the developed program was verified, Also, the developed program was applied to simulations of high-velocity multi-blow forging processes. Two types of workpiece configurations, cylinder and block, were used for high-velocity multi-blow forging simulations. As a result of multi-blow forging process simulation, it was found that the change of the blow efficiencies and the clash load generated by the blow operations could be efficiently analyzed
UBET ANALYSIS OF THE CLOSED-PASS RING ROLLING OF RINGS HAVING ARBITRARILY-SHAPED PROFILES
No full textA simple but effective upper-bound elemental technique (UBET) for prediction of the torque and the deformation pattern during the ring-rolling of rings having arbitrarily shaped profiles is proposed. In order to describe the three-dimensional material flow of profile ring rolling, a new element with a curvilinear side is introduced and the corresponding kinematically admissible velocity field is derived. Upper-bound analysis is carried out for rolling rings with a circular groove or protrusion having a round corner fillet. Comparing with the experimental results, the roll torque and the profile formation are predicted with reasonable accuracy. The effects of some parameters are investigated also. Despite the simplifying assumptions, some aspects of the deformation mechanics in profile ring rolling are shown to be described successfully by the proposed method
Pharmacokinetic parameters of IMB-YH-4py5-2H following a single oral dose of 50, 100, and 200 mg/kg in rats (n = 6).
No full textPharmacokinetic parameters of IMB-YH-4py5-2H following a single oral dose of 50, 100, and 200 mg/kg in rats (n = 6).</p
Concentrations of IMB-YH-4py5-2H following a single oral dose of 100 mg/kg in rat plasma, lung homogenate, ELF, and AMs (n = 6).
No full textConcentrations of IMB-YH-4py5-2H following a single oral dose of 100 mg/kg in rat plasma, lung homogenate, ELF, and AMs (n = 6).</p
- …
