4,359 research outputs found
An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+.
No full textUsing Path analysis to examine causal relationships among balanced scorecard performance indicators for general hospitals: the case of a public hospital system in Taiwan
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Impulsive sources localisation in noisy environment using modified beamforming method
No full textWhen a machine has faults in its rotating part, it normally generates periodic vibration or acoustic signals. These signals are often periodic but impulsive. This paper addresses the way in which we can find where the impulsive sources are. We propose a signal processing method that can identify impulsive sources' location. The method is robust with respect to noise; spatially distributed noise. Numerical simulation and experiments are performed to verify the method. Results show that the proposed technique is quite powerful for localising the sources in noisy environments. The method also required less microphones than conventional beamforming method. (c) 2005 Elsevier Ltd. All rights reserved
YC-1 induces G
No full textOral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a concentration-dependent and time-dependent decrease in viability of CAR cells analyzed by MTT assay. Real-time image analysis of CAR cells by IncuCyte™ Kinetic Live Cell Imaging System demonstrated that YC-1 inhibited cell proliferation and reduced cell confluence in a time-dependent manner. Results from flow cytometric analysis revealed that YC-1 promoted G0/G1 phase arrest and provoked apoptosis in CAR cells. The effects of cell cycle arrest by YC-1 were further supported by up-regulation of p21 and down-regulation of cyclin A, D, E and CDK2 protein levels. TUNEL staining showed that YC-1 caused DNA fragmentation, a late stage feature of apoptosis. In addition, YC-1 increased the activities of caspase-9 and caspase-3, disrupted the mitochondrial membrane potential (AYm) and stimulated ROS production in CAR cells. The protein levels of cytochrome c, Bax and Bak were elevated while Bcl-2 protein expression was attenuated in YC-1-treated CAR cells. In summary, YC-1 suppressed the viability of cisplatin-resistant CAR cells through inhibiting cell proliferation, arresting cell cycle at G0/G1 phase and triggering mitochondria-mediated apoptosis. Our results provide evidences to support the potentially therapeutic application of YC-1 on fighting against drug resistant oral cancer in the future
The preparation and characterization of micro-sized emulsion using vegetable oils for the remediation of DNAPL
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Health-Related Quality of Life and Medical Cost of Early-Stages Breast Cancer.Patients underwent Breast-Conserving Surgery versus Modified Radical Mastectomy.
No full textNovobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone.
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