113,750 research outputs found
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Scanning tunneling spectroscopy on YBa2Cu3Oy/PrBa2Cu3Oy/YBa2Cu3Oy sandwiched junctions and YBa2Cu3Oy/Y0.5Pr0.5Ba2Cu3Oy superlattices
No full text4d/2d Correspondence: Instantons and W-Algebras
Full text linkIn this thesis, we study the 4d/2d correspondence of Alday-Gaiotto-Tachikawa, which relates the class of 4-dimensional N=2 gauge theories (theories of class S) to a 2-dimensional conformal field theory. The 4d gauge theories are obtained by compactifying 6-dimensional N=(2, 0) theory of type A, D, E on a Riemann surface C. On the 2-dimensional side, we have Toda theory on the surface C with W-algebra symmetry, which is an extension of the Virasoro symmetry. In particular, the instanton partition function of the 4d gauge theory is reproduced by a conformal/chiral block of Virasoro/W-algebra. We develop techniques to compute the partition functions on 4d and 2d sides, for various gauge groups and matter fields.
We generalize the Alday-Gaiotto-Tachikawa 4d/2d correspondence to various cases. First, we study N=2 pure Yang-Mills theory with arbitrary gauge groups, including the exceptional groups. We explicitly construct the corresponding W-algebra currents, and confirm the correspondence holds at 1-instanton level. Second, we study the conformal quiver theory with Sp(1)-SO(4) gauge group. Finally, we study Sicilian gauge theories with trifundamental half-hypermultiplets. We also find that the conformal theories with Sp(1) gauge group and SU(2) gauge group have different instanton partition functions in terms of bare gauge couplings. We show this is an artifact of the renormalization scheme, by explicitly constructing a map between the bare couplings and studying its geometrical interpretations. This demonstrates the scheme independence of renormalization at the non-perturbative level.</p
Recombination Mechanism of InGaN Multiple Quantum Wells Grown by Metalorganic Chemical Vapor Deposition
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Electrochemical Detection of High-Sensitivity C-Reactive Protein Based on Biomimic Design of Electroactive Nanoassembly Multilayers
No full textIn this study, the gold electrode was modified with a ferrocene-terminated alkanethiol and phospholipid complex layer, which is designed and fabricated to serve as a C-reactive protein sensor using electrochemical determination. The scope of this research is to know whether a ferrocene-terminated self-assembled monolayer and hydrogenated phosphocholine hybrid bilayer could be used to perform C-reactive protein detection or not. After a series of experiments, the result shows that mixed electroactive SAM can facilitate electrons transferring from the solution to the electrode. And after coating phospholipids, this phenomenon seems to be hindered from the electrode. But this provoked small electrical signal of the recognition layer still allows for further usage. According to the result, it can be used to measure C-reactive protein and its electrochemical property and the changes of the electrode's electron transfer ability are characterized by cyclic voltammetry. This study demonstrates self-assembled ferrocene-terminated alkanethiol and phospholipid complex structure has potential as a C-reactive protein sensor and is stable to detect in the aqueous phase.補正完
Machilus pingii W. C. Cheng ex Yen C. Yang 1945
No full textMachilus pingii W.C.Cheng ex Yen C. Yang (1945: 76). Type:— CHINA. Chongqing [Szechuan], Beibei District [Pa-hsien, Peipei], Jinyun Shan [Tsin-yun-shan], 6 April 1939, C. Pei 7092 (lectotype designated here, NAS00070923; isolectotypes NAS00070925, PE00029013). Remaining syntypes: CHINA. Sichuan [Sikang]: Ya-an, near Ma Liu Chang [Ma-kiou-Chang], 6 August 1939, Y. C . Yang 3423 (NAS00070924, PE00935898). Paratypes in CQNM: CHINA. Sichuan: Emei Shan, elev. ca. 400 m, 3 April 1940, W. P . Fang 13984 (CQNM0015775, IBK00009356, KUN0172559, PE00618771, SZ00163694) & W. P . Fang 13985 (CQNM0015779, KUN0172561, PE00618792, SZ00163689); Sichuan: without locality, 1930, T . Tang [or F. T. Wang] 23124 (CQNM0015780, IBSC0062447, KUN0172569, PE00029016, SZ). = Machilus nanmu (Oliver 1880: 10) Hemsl. in Forbes & Hemsley (1891: 376). Note: —In the protologue, Yang (1945) designated C. Pei 7092 and Y. C. Yang 3423 as flowering and fruiting types, respectively, and both are syntypes according to Art. 9.6 (Turland et al. 2018). Three duplicates (NAS00070923, NAS00070925, PE00029013) of C. Pei 7092 and two duplicates (NAS00070924, PE 00935898) were traced. Among of them, two duplicates (NAS00070923,NAS00070924) bear the annotation of Yang’s handwritten. Here, the duplicate NAS00070923 is here chosen as the lectotype because of better condition. Among of the paratypes cited by Yang, the two gatherings W. P. Fang 19834 & 13985 collected from Mt. Emei are traced, and Fang 13985 was erroneously cited as ‘19985’ in the protologue by Yang (1945).Published as part of Chen, Feng & He, Hai, 2022, The historical relics in Chongqing Natural History Museum: An annotated checklist of original materials for 37 names of Chinese seed plants, pp. 38-52 in Phytotaxa 530 (1) on page 43, DOI: 10.11646/phytotaxa.530.1.3, http://zenodo.org/record/582393
Synthesis of New Fluorene-Indolocarbazole Alternating Copolymers for Light-Emitting Diodes and Field Effect Transistors
No full textCorrespondence and Photograph from Ernest W. Wright to Dr. C. A. Bacote, August 30, 1977
No full textCorrespondence between Ernest W. Wright (Employment Security Agency, Georgia Department of Labor) and Dr. C. A. Bacote, 30 August 1977. Enclosed 8"x10" photograph circa 1955, depicting voter registration participants. Written on Verso: "Left to Right: (Seated): Dr. Clarence A. Bacote, Dr. William Hale, Mr. Ron Harris? Dr. Robert Brisbane (Standing): Mr. Michael? Mr. C. A. Scott? Mr. Milton White"
Mellin-Transform-Based Performance Analysis of FFH -ary FSK Using Product Combining for Combatting Partial-Band Noise Jamming
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