99,177 research outputs found
Nan hua zhen jing san zhu da quan
No full text陳懿典輯.綫裝, 1函.框20.4 x 12.4公分, 分上下欄. 上欄框為眉欄, 刻註, 小字20行, 每行9字, 下欄框為正文, 10行18字, 小字雙行同. 白口, 雙黑魚尾, 四周單邊, 版心上鐫"增補南華經三註", 中鐫卷名, 下鐫葉次及"自新齋". 行間有朱, 藍墨圈點.内封面題"南華眞經三註大全, 書林余翼我梓行" ; 卷末牌記刻"萬曆癸巳歲冬月自新齋余紹崖梓"第一卷第十一葉有一字條書: "羊角鳳之屈曲也二字屬下魏之靈徵志可併考矣"Xian zhuang, 1 han.Kuang 20.4 x 12.4 gong fen, fen shang xia lan. Shang lan kuang wei mei lan, ke zhu, xiao zi 20 hang, mei hang 9 zi, xia lan kuang wei zheng wen, 10 hang 18 zi, xiao zi shuang hang tong. Bai kou, shuang hei yu wei, si zhou dan bian, ban xin shang juan "Zeng bu nan hua jing san zhu", zhong juan juan ming, xia juan ye ci ji "Zi xin zhai". Hang jian you zhu, lan mai quan dian.Nei feng mian ti "Nan hua zhen jing san zhu da quan, shu lin yu yi wo zi xing" ; juan mo pai ji ke "Wanli gui si sui dong yue Zi xin zhai Yu Shaoya zi"Di yi juan di shi yi ye you yi zi tiao shu: "yang jiao feng zhi qu qu ye er zi shu xia wei zhi ling zheng zhi ke bing kao yi"Chen Yidian ji
Neural Mobilization Techniques in a Patient with Median and Ulnar Nerve Injuries-a Case Report
No full textNan hua jing
No full text[v. 1-6]. 南華真經 / 莊子. -- [v. 7-12]. 荀子 / 荀子. -- [v.13-14]. 中說 / 王通. -- [v. 15-16]. 沖虛至德真經 / 列子. -- [v. 17]. 老子道德經 / 老子. -- [v. 18-20] 新纂門目五臣音註揚子法言 / 揚雄.[v. 1-6]. Nan hua zhen jing / Zhuangzi. -- [v. 7-12]. Xunzi / Xunzi. -- [v.13-14]. Zhong shuo / Wang Tong. -- [v. 15-16]. Chong xu zhi de zhen jing / Liezi. -- [v. 17]. Laozi dao de jing / Laozi. -- [v. 18-20] Xin zuan men mu wu chen yin zhu Yangzi fa yan / Yang Xiong.題名由編目者擬定.綫裝.框19 x 14.2公分, 8行17字, 小字雙行同, 白口, 單白魚尾, 四周雙邊."荀子"由"桐蔭書屋"出版; "中說", "沖虛至德真經", "老子道德經", "新纂門目五臣音註揚子法言"出版者不詳.鈐有朱印.Ti ming you bian mu zhe ni ding.Xian zhuang.Kuang 19 x 14.2 gong fen, 8 hang17 zi, xiao zi shuang hang tong, bai kou, dan bai yu wei, si zhou shuang bian."Xunzi" you "Tong yin shu wu"chu ban; "Zhong shuo", "Chong xu zhi de zhen jing", "Laozi dao de jing", "Xin zuan men mu wu chen yin zhu Yangzi fa yan" chu ban zhe bu xiang.Qian you zhu yin
Fear & Care in the Museum: The Politics of Exhibiting Chinese Games - Jing Yang (Allison), City University of Hong Kong
No full textFear & Care in the Museum: The Politics of Exhibiting Chinese Games - Jing Yang (Allison), City University of Hong Kong</p
Glucocorticoid receptor activation by long acting steroids and its modification by inflammation
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Glucocorticoids have an effective anti-inflammatory, anti-proliferative and immunomodulatory activity. Therefore this class of drugs is used worldwide for the treatment of inflammatory diseases and to prevent rejection following organ transplantation. Inhaled glucocorticoids are the cornerstone treatment of asthma and advanced chronic obstructive pulmonary disease (COPD). The new long acting glucocorticoids mometasone and Ciclesonide have recently been introduced for the treatment of asthma. The aim of these studies is to assess the kinetics and molecular pathways of glucocorticoid receptor (GR) activation and traffic in human lung fibroblasts and bronchial smooth muscle cells. Furthermore the effects of new long acting glucocorticoids on GR activation, complex formation with the transcription factor C/EBP and its isoforms proliferation will be evaluated. Glucocorticoids enter the cytosol of cells by diffusion and bind to an intracellular specific receptor, the glucocorticoid receptor (GR), inducing a conformational change and leading thereby to its activation. The active GR translocates into the nucleus, where it binds to its cognate DNA recognition sequence, the glucocorticoid response element (GRE). Often the activation of the GR is associated with a parallel activation of the transcription factor C/EBP-, followed by de novo synthesis of p21(waf1/cip1), which in turn is mediating the GR dependent inhibition of the cell cycle. Both, GR and C/EBP- are necessary to induce and activate p21(waf1/cip1) and to arrest the cell cycle at the transition from the G1- to the S-phase. Fibroblasts and bronchial smooth muscle cells are centrally involved in airway remodeling of patients with asthma and COPD. Therefore three cell types were chosen to assess the effect of the classical and new glucocorticoids on GR activation, cell proliferation and extracellular matrix deposition under different conditions. Four cell
culture conditions were chosen to mimic different stages of inflammation: confluent cells without serum representing intact, not damaged tissue; confluent cells with 5% fetal calf serum to mimic early stages of inflammation; sub-confluent cells without serum to represent damaged tissue with no active inflammatory process; sub-confluent cells with 5% serum to represented tissue with active inflammation-induced lung tissue remodeling.
The results showed that cell density and inflammation alter the localization and function of the GR. In sub-confluent cells dexamethasone activated the nuclear accumulation and DNA binding of the GR persistently, while in confluent cells its activity declined. In sub-confluent cells, GR interacted with a 42 kDa C/EBP-α isoprotein, which resulted in an up-regulation of p21(Waf1/Cip1) expression and suppression of proliferation. In confluent cells glucocorticoids induced p27(Kip1) expression via p38 MAP kinase and a 52 kDa C/EBP-β isoprotein. Furthermore, p27(Kip1) did not mediate the anti-proliferative effect of glucocorticoids, but simultaneous inhibition of p21(Waf1/Cip1) and p27(Kip1) unlocked contact inhibition in confluent cell cultures.
The studies further showed that in lung fibroblasts the long acting steroid mometasone in contrast to ciclesonide or the short acting steroids dexamethasone, budesonide or fluticasone did not induce tachyphylaxis and had a preferable effect on airway remodeling. Mometasone maintained the increased GR activity significantly over 24 hours, compared to that induced by dexamethasone which peaked at 6 hours and declined thereafter. Similarly drug specific effects were observed for the expression of C/EBP- and p21(Waf1/Cip1). The anti-proliferative effect of mometasone was significantly stronger and long lasting compared to all other steroids. Similar anti-proliferative effects were observed in bronchial smooth muscle cells. Regarding airway remodeling we observed that mometasone, in contrast to all other steroids, did not further stimulate serum dependent synthesis and deposition of extracellular matrix and did not affect matrix metalloproteinase-2 and -9 expression or activity. Therefore this novel steroid will have a lower modulatory effect of tissue remodeling compared to the other steroids. Interestingly the long duration effects of the new glucocorticoid ciclesonide originated from the metabolism of the epithelial cells.
In conclusion, our findings suggest that the action of glucocorticoids differs under non-inflammatory and inflammatory conditions in human lung fibroblasts and bronchial smooth muscle cells. Different doses of inhaled steroids might therefore be applied in patient with asthma and COPD dependent on the current status of inflammation in order to reduce side effects. The long acting glucocorticoid mometasone might help to reduce overall steroid dosage and might thereby reduce the risk of tachyphylaxis, enhanced tissue remodeling and other typical steroid side effects. Ciclosonide is a new long acting steroid, but its action on mesenchymal cells depends on the function of epithelial cells.
These studies not only improve the understanding of the effect of different glucocorticoid on mesenchymal lung cells but might also help to find optional treatment doses
Improving the performance of outbreak detection algorithms by classifying the levels of disease incidence
No full textWe evaluated a novel strategy to improve the performance of outbreak detection algorithms, namely setting the alerting threshold separately in each region according to the disease incidence in that region. By using data on hand, foot and mouth disease in Shandong province, China, we evaluated the impact of disease incidence on the performance of outbreak detection algorithms (EARS-C1, C2 and C3). Compared to applying the same algorithm and threshold to the whole region, setting the optimal threshold in each region according to the level of disease incidence (i.e., high, middle, and low) enhanced sensitivity (C1: from 94.4% to 99.1%, C2: from 93.5% to 95.4%, C3: from 91.7% to 95.4%) and reduced the number of alert signals (the percentage of reduction is C1?4.3%, C2?11.9%, C3?10.3%). Our findings illustrate a general method for improving the accuracy of detection algorithms that is potentially applicable broadly to other diseases and regions
Wireless LAN
No full textHanya dalam beberapa tahun datangnya Wireless LAN sudah mampu menarik pasar jaringan lokal. Wireless LAN sangat dibutuhkan karena LAN tradisional tidak mampu menjawab kebutuhan masyarakat yang menginginkan jaringan yang bisa dipindah ke segala tempat (mobile system). Kesulitan awal Wireless LAN adalah kecepatan transmisi yang lambat, tetapi seiring dengan kemajuan teknologi membuat masalah ini dapat diatasi. Masalah lainnya adalah biaya yang diperlukan pada awalnya sangat mahal mengingat teknologi wireless saat itu tidak dapat menjawab secara cepat tetapi saat ini dengan kemajuan elektronika dan komunikasi yang begitu cepatnya membuat Wireless LAN menjadi pilihan yang tepat, di mana biaya dapat ditekan serendah mungkin dengan hasil yang optimal. Tulisan ini akan memperlihatkan teknologi wireless dipakai pada jaringan LAN, manfaat yang akan diambil, perkembangan yang ada dan konsep yang dapat dipakai
EMPLOYEE SELF-SERVICES USING J2EE TECHNOLOGY ON A MVC ARCHITECTURE
No full textMaster'sMASTER OF SCIENCE IN COMPUTER SCIENCEDissertation Supervisors: 1. Assoc. Prof. Hsu Wen Jing, SMA Fellow, NTU. 2. Mr. Cho Jia Yang, elipva Ltd
Replication Data for: Does digital government transformation reduce CO2 emissions? Evidence from China
No full textThe data and programs replicate tables and figures from "Does digital government transformation reduce CO2 emissions? Evidence from China", by Jing WEN, Xin ZHANG, and Yongliang YANG
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