6,184 research outputs found
Fibronectin modulates the morphology of osteoblast-like cells (MG-63) on nano-grooved substrates
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Angular dependence of tunneling magneto resistance in La0.7Sr0.3MnO3 step-edge junctions
No full textKnee proprioception in patients with osteosarcoma around the Knee after modular endoprosthetic reconstruction
No full textHome-based trunk-strengthening exercise for osteoporotic and osteopenic postmenopausal women without fracture - a pilot study
No full textSpinal performance and functional impairment in postmenopausal women with osteoporosis and osteopenia without vertebral fracture
No full textThe Effects of Sensorimotor Training on Knee Proprioception and Function for Patients with Knee Osteoarthritis: A Preliminary Report
No full textRapid prototyping and reverse engineering application for orthopedic surgery planning
No full textThis paper describes rapid prototyping (RP) and reverse engineering (RE) application for orthopedic surgery planning to improve the efficiency and accuracy of the orthopedic surgery. Using the symmetrical characteristics of the human body, CAD data of undamaged bone of the injured area are generated from a mirror transformation Of undamaged bone data for the uninjured area. The physical model before the injury is manufactured from Polyjet RP process. The surgical plan, including the selection of the proper implant, pre-forming of the implant and decision of fixation positions, etc., is determined by a physical simulation using the physical model. In order to examine the applicability and efficiency Of the Surgical planning technology, two case studies, Such as a distal tibia comminuted fracture and an iliac wing fracture of pelvis, are carried Out. From the results of the examination, it has been shown that the RP and RE can be applied to orthopedic surgical planning and can be an efficient surgical tool
Additional role of nicotinic acid hydroxylase for the transformation of 3-succinoyl-pyridine by Pseudomonas sp. JY-Q
No full textApplied Environmental Microbiology, 87, e02740-20Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Nicotine and nicotinic acid (NA) are both considered to be representatives of N-heterocyclic aromatic compounds, and their degradation pathways have been revealed in Pseudomonas species. However, the cooccurrence of these two pathways has only been observed in Pseudomonas sp. strain JY-Q. The nicotine pyrrolidine catabolism pathway of strain JY-Q consists of the functional modules Nic1, Spm, and Nic2. The module enzyme, 3-succinoylpyridine monooxygenase (Spm), catalyzes transformation of 3-succinoyl-pyridine (SP) to 6-hydroxy-3-succinoyl-pyridine (HSP). There exist two homologous but not identical Spm enzymes (namely, Spm1 and Spm2) in JY-Q. However, when spm1 and spm2 were both in-frame deleted, the mutant still grew well in basic salt medium (BSM) supplemented with nicotine as the sole carbon/nitrogen nutrition, suggesting that there exists an alternative pathway responsible for SP catabolism in JY-Q. NicAB, an enzyme accounting for NA hydroxylation, contains reorganized domains similar to those of Spm. When the JY-Q_nicAB gene (nicAB in strain JY-Q) was introduced into another Pseudomonas strain, one that is unable to degrade NA, the resultant recombinant strain exhibited the ability to transform SP to HSP, but without the ability to metabolize NA. Here, we conclude that NicAB in strain JY-Q exhibits an additional role in SP transformation. The other genes in the NA cluster, NicXDFE (Nic2 homolog), then also exhibit a role in subsequent HSP metabolism for energy yield. This finding also suggests that the cooccurrence of nicotine and NA degradation genes in strain JY-Q represents an advantage for JY-Q, making it more effective and flexible for the degradation of nicotine.China Postdoctoral Science Foundationhttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1128/AEM.02740-2
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