21 research outputs found
Analisis Aspek Pemidanaan Terhadap Pelaku Eksploitasi Seksual Terhadap Anak Berdasarkan Perspektif Hukum Perlindungan Anak
No full textBerdasarkan basil penelitian dapat disimpulkan bahwa upaya hukum perlindungan terhadap anak yang menjadi korban tindak pidana perdagangan anak untuk eksploitasi seksual baik di dalam Undang-undang Perlindungan Anak dan Undang-undang Nomor 21 Tahun 2007 tentang Pemberantasan Tindak Pidana Perdagangan Orang dibagi atas 3 (tiga) tahap yaitu tahap perlindungan pada saat terjadinya tindak pidana perdagangan orang anak untuk eksploitasi seksual, tahap perlindungan pada saat persidangan pelaku tindak pidana perdagangan orang anak untuk eksploitasi seksual dan tahap setelah persidangan yaitu pemberian hak untuk mengajukan ke pengadilan berupa hak restitusi yang menjadi tanggung jawab pelaku kejahatan tindak pidana perdagangan orang anak untuk eksploitasi seksual
Replication data for: A Reassessment of `Do Teenagers Respond to HIV Risk Information?'
No full textThis paper uses simple difference model to exploit the original study's randomization at the school level, comparing only those classrooms that were treated to the controlled. This procedure allows us to reassess the `spillover' problem and to eliminate the bias of the difference-in-difference model in the original paper, because information on the relative risk of HIV infection (RR) affects only 8th grade classes. We then provide a falsification test for the 'placebo effect' theory of treatment spillover by comparing only 7th grade classrooms (the control cohort). Finally, we use subgroup analysis in all of our models in order to disaggregate the true effect of RR from that of RR and TT (HIV prevention teacher training program) together and RR conditional on TT. We find that the RR information program is not as robust as Dupas' original findings suggest, and the treatment is actually harmful because it increases the overall incidence of sex, and it may be especially harmful for boys given their relative risk ratios: The RR program increases the number of both boys and girls who report that they have ever had sex; and, we find no evidence for Dupas' key finding that it decreases the age gap between the girl and her partner. The RR program also increases the number of boys who report not only having sex, but having sex with multiple partners. And there is no corresponding increase in the number who report using a condom
Rejestrowanie czasu pracy kierowcy jako element bezpieczeństwa europejskiego systemu dobrej reputacji
No full textTachograph belongs to On Board Recording Devices. It was initially introduced for the railroads in order to companies could better document irregularities. The inventor of the tachograph was Max Maria von Weber, an administrative official, engineer and author. The Hasler Event Recorder was introduced in the 1920s. Regrettably, the construction of analogue tachograph, an original type of tachograph used in road transport, encouraged to numerous frauds and counterfeits of social rules for drivers. Secure digital tachograph system is indisputably a means having the great influence on road safety, enforcement of the social conditions for drivers in road transport as well as supporting the fair competition between road transport undertakings. In order to better monitor the compliance of road transport with the rules in force, inter alia the provisions on usage the digital tachographs, the European Union regulation introduces the European Registers of Road Transport Undertakings (ERRU), a system that allows a better exchange of information between Member States.W artykule przedstawiono tematykę cyfrowych urządzeń rejestrujących przeznaczonych do rejestrowania czasu pracy kierowców w aspekcie wdrożenia w Unii Europejskiej systemu tzw. dobrej reputacji. Ponadto w artykule zaprezentowano elementy bezpieczeństwa tego systemu w aspekcie innych uczestników ruchu drogowego i ich bezpieczeństwa na drodze
Comprehensive Nutritional Evaluation and Essential Oil Type Analysis of 14 Purple Perilla frutescens Lines
No full textIn order to screen Perilla resources suitable for both medicine and food, basic nutritional quality, main active components and mineral content were determined in 14 purple Perilla frutescens lines (No.C01~C14), which were collected from Guizhou, Hunan, Shanxi and Heilongjiang provinces. The nutritional quality of Perilla leaves was evaluated by factor analysis and systematic cluster analysis. In addition, the essential oil types of the Perilla lines were also analyzed. The results showed that the content of crude protein, crude fat, crude fiber, soluble protein, total free amino acids and soluble sugar were 12.87~19.52, 2.07~4.19, 6.59~9.84 g/100 g, 0.99~2.49, 0.17~1.57 and 28.90~61.54 g/kg, respectively. The contents of flavonoids, total phenols and vitamin C were 13.28~24.35 g/kg, 59.26~99.18 mg/kg and 1.16~8.17 mg/100 g. The content of Fe, Zn, Mn and Cu was 13.96~27.86, 5.60~8.94, 4.63~19.74 and 0.52~2.61 mg/kg, respectively. Factor analysis showed that the four common factors of ''sugar and mineral elements'', ''active substances'', ''protein'' and ''fat'' could be extracted from the multitudinous nutrient factors of Perilla leaves. The best comprehensive quality performance was C05, followed by C12, C11, C06 and C10. Cluster analysis indicated that 14 Perilla lines could be divided into three groups, they were ''high-sugar and high-mineral group'', ''high-fat and high-protein and high-active ingredient group'' and ''high-fiber and low-nutrition group'', including 8, 3 and 3 lines correspondingly. The essential oil detection and composition analysis showed that the content of essential oil ranged from 0.25% to 1.09% in 14 Perilla lines. The chemotype of essential oil of 14 Perilla lines could be divided into four types: PA type (rich in L-perillaldehyde), pp-m type (rich in 1,3-benzodioxole, 4-methoxy-6-(2-propenyl)-), atypical EK+type (mainly containing elsholtzia ketone) and MP type (rich in 1-(furan-2-yl)-4-methylpentan-1-one), including 7, 1, 2 and 4 Perilla lines respectively. After comprehensive evaluation, it was concluded that C05 was the best line in quality and was also rich in PA-type essential oil, which could be developed into both medicine and food
Clinical and economic outcomes among elderly myocardial infarction survivors in the United States
No full textP3‐352: DIAGNOSTIC AND TREATMENT PATTERNS AND HEALTHCARE RESOURCE UTILIZATION AMONG DIAGNOSED DEMENTIA PATIENTS IN THE UNITED STATES
No full textIdentification of heat responsive genes in Brassica napus siliques at the seed-filling stage through transcriptional profiling.
No full textHigh temperature stress results in yield loss and alterations to seed composition during seed filling in oilseed rape (Brassica napus). However, the mechanism underlying this heat response is poorly understood. In this study, global transcription profiles of 20 d-old siliques of B. napus were analyzed after heat stress using a Brassica 95k EST microarray. The up-regulated genes included many HSF/HSP transcripts and other heat-related marker genes, such as ROF2, DREB2a, MBF1c and Hsa32, reflecting the conservation of key heat resistance factors among plants. Other up-regulated genes were preferentially expressed in heat-stressed silique walls or seeds, including some transcription factors and potential developmental regulators. In contrast, down-regulated genes differed between the silique wall and seeds and were largely tied to the biological functions of each tissue, such as glucosinolate metabolism in the silique wall and flavonoid synthesis in seeds. Additionally, a large proportion (one-third) of these differentially expressed genes had unknown functions. Based on these gene expression profiles, Arabidopsis mutants for eight heat-induced Brassica homologous genes were treated with different heat stress methods, and thermotolerance varied with each mutation, heat stress regimen and plant development stage. At least two of the eight mutants exhibited sensitivity to the heat treatments, suggesting the importance of the respective genes in responding to heat stress. In summary, this study elucidated the molecular bases of the heat responses in siliques during later reproductive stages and provides valuable information and gene resources for the genetic improvement of heat tolerance in oilseed rape breeding
SUN-757 Sustained Improvements in Patient-Reported Outcomes Across Age Groups in Burosumab-Treated X-linked Hypophosphatemia (XLH): Results From the XLH Disease Monitoring Program
No full textIntroduction: Burosumab, a fully human FGF23-neutralizing antibody, improved outcomes in adults and children with X-linked hypophosphatemia (XLH) in 24- and 64-week randomized controlled trials, respectively. This analysis describes real-world changes in patient-reported outcomes (PROs) over ≤3 years (y) in burosumab-treated individuals with XLH, including age groups with previously limited data (13-17 and >65y). Methods: Participants (pts) initiating burosumab after enrollment and before the Year (Y) 1 visit in the XLH Disease Monitoring Program (DMP); NCT03651505, a multi-country observational study) were evaluated. In children, change from baseline in Patient-Reported Outcomes Measurement Information System (PROMIS) T-scores at Y1 and 3 were evaluated to assess fatigue, pain interference, and physical function (PF) mobility. In adults, change from baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and PROMIS PF T-scores at Y1 and 3 visits were evaluated to assess pain severity, joint stiffness, and PF. Results: At baseline (N=116) and Y1 (n=108), most groups included >10 pts, but the >65y group included 3. Y3 (n=76) group sample size range was 3-22. In children (n=83), mean ± standard deviation (SD) PROMIS pain interference improved significantly at Y1 (n=36: −3.6 ± 8.5, P=0.016) and Y3 (n=29: −4.8 ± 10.1, P=0.017). Mean PROMIS fatigue and PF mobility improved descriptively at Y1 and 3. The 5-12y group showed descriptive improvements in all PROMIS domains at Y1 and 3, with a significant change for pain at Y1 (n=25: −4.2 ± 7.3, P=0.008). The 13-17y group showed descriptive improvements in fatigue and pain interference at Y1 and 3. In adults (n=72), mean ± SD WOMAC scores improved significantly at Y1 (pain: −7.5 ± 18.8, P=0.001; stiffness: −12.2 ± 23.6, P<0.0001; PF: −6.3 ± 15.5, P=0.001), and Y3 (n=47) (pain: −11.3 ± 16.9, P<0.0001; stiffness: −16.8 ± 21.7, P<0.0001; PF: −10.8 ± 16.6; P<0.0001). Mean ± SD PROMIS PF score improved significantly at Y1 (1.5 ± 5.6, P=0.025) and remained stable at Y3 (1.6 ± 5.8). All adult groups had descriptive reductions from baseline in all WOMAC domains at Y1 and 3. Significant improvements in mean ± SD scores were seen at Y1 and 3 for pain in the 30-39y (Y1: −7.5 ± 11.3, P=0.0036; Y3: −10.3 ± 12.2, P=0.0054) and 50-64y (Y1: −13.3 ± 18.9, P=0.0333; Y3: −21.9 ± 13.1, P=0.0021) groups, stiffness in the 18-29y (Y1: −22.1 ± 28.5, P=0.057; Y3: −25.0 ± 23.2, P=0.0185) and 30-39y (Y1: −10.4 ± 17.9, P=0.0092; Y3: −13.3 ± 19.2, P=0.175) groups, and PF in the 50-64y (Y1: −8.7 ± 13.5, P=0.0467; Y3: −14.9 ± 9.1, P=0.0023) group. Conclusion: Children with XLH showed early and sustained improvement in pain interference. Adults with XLH also showed significant improvements at DMP Y1 and 3 in all WOMAC domains. Despite small sample sizes, this analysis provides real-world data on the positive impact of burosumab treatment on PROs
Differentially expressed genes involved in flavonoid and phenylpropanoid synthesis.
No full text<p>The green circle represents SW, and the yellow circle indicates seed. Arrows pointing up show increased expression; arrows pointing down show decreased expressions. Abbreviations: PAL, phenylalanine ammonia lyase; C4H, cinnamate 4-hydroxylase; 4CL, 4-coumarate-CoA ligase; CHS, chalcone synthase; CHI, chalcone isomerase; F3H, flavanone 3-hydroxylase; F′3H, flavonoid 3′-hydroxylase; FLS, flavonol synthase; FGT, flavonol glycosyltransferase; DFR, dihydroflavonol 4-reductase; ANS, anthocyanidin synthase; AGT, anthocyani(di)n glycosyltransferase; AAT, anthocyanin acyltransferase; GST, glutathione S-transferase; ANR, anthocyanidin reductase. This scheme was based on the analysis by Lillo et al. (2008) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101914#pone.0101914-Lillo1" target="_blank">[98]</a>.</p
Differentially expressed genes involved in the aliphatic and indolic glucosinolate biosynthetic pathways.
No full text<p>The green circle represents the SW, and the yellow circle indicates seeds. Arrows pointing up indicate increased expression; arrows pointing down indicate decreased expression. Abbreviations: BCAT, branched-chain amino acid aminotransferase; MAM, methylthioalkylmalate synthase; IPMDH, isopropylmalate dehydrogenase; CYP, cytochrome P450; GST, glutathione transferase; GGP1, γ-glutamyl peptidase 1; SUR1, C-S lyase; UGT, glucosyltransferase; SOT, sulfotransferase; FMO<sub>GS-OX</sub>, flavin monooxygenase; AOP2, 2-oxoglutarate-dependent dioxygenase; GS-OH, 2-oxo acid-dependent dioxygenase; APS, adenosine 5′-phosphosulfate; APK, APS kinase; SULTR, sulfate transporter; PAPS, 3′-phosphoadenosine-5′-phosphosulfate. This scheme was based on analyses by Maruyama-Nakashita et al. (2006) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101914#pone.0101914-MaruyamaNakashita1" target="_blank">[97]</a> and Sønderby et al. (2010) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101914#pone.0101914-Snderby1" target="_blank">[62]</a>.</p
