81 research outputs found
Supplemental material for Risk of bacteremia in hospitalised patients with inflammatory bowel disease: a 9-year cohort study
No full textSupplemental Material for Risk of bacteremia in hospitalised patients with inflammatory bowel disease: a 9-year cohort study by Idan Goren, Adi Brom, Henit Yanai, Amir Dagan, Gad Segal and Ariel Israel in United European Gastroenterology Journal</p
The Impact of Crohn’s Perianal Fistula on Quality of Life: Results of an International Patient Survey
Full text linkLay Summary Results from an online survey completed by patients with Crohn's disease (CD) and perianal fistulas showed the presence of perianal fistulae has a greater negative impact as compared to CD-only patients. These results may help practitioners address patient burden.Background Crohn's perianal fistula is a disabling manifestation of Crohn's disease. However, the additional burden of perianal fistula on patients with only Crohn's disease remains to be addressed. This patient-reported survey considered outcomes of two domains: "diagnosis" (eg, symptoms) and "living with the disease" (eg, quality of life, well-being, and relationships). Methods Patients with perianal fistula and Crohn's disease completed an online, self-selective, anonymous, 46-item survey available in 11 languages hosted on the European Federation of Crohn's & Ulcerative Colitis Associations and national patient association websites. The survey was conducted between July and December 2019 in Europe and other regions. Likert scales and closed questions were used to assess outcomes. Results Of the 820 respondents with Crohn's disease (67.2% women; median age, 40.0 years), 532 (64.9%) reported the presence of perianal fistula. Patients with perianal fistula reported a greater impact on overall quality of life (P < .001), well-being (P < .001), relationships (P < .001), social life (P = .001), and work life (P = .012) than patients with only Crohn's disease. Conclusions Perianal fistulas impact several domains of the life of patients with Crohn's disease. These results may help healthcare practitioners plan therapeutic strategies that address the symptomatic and psychological burden experienced by patients with perianal fistulizing Crohn's disease
sj-docx-1-tag-10.1177_17562848221092594 – Supplemental material for Advanced technology for assessment of endoscopic and histological activity in ulcerative colitis: a systematic review and meta-analysis
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848221092594 for Advanced technology for assessment of endoscopic and histological activity in ulcerative colitis: a systematic review and meta-analysis by Olga Maria Nardone, Yifat Snir, James Hodson, Rosanna Cannatelli, Nunzia Labarile, Keith Siau, Cesare Hassan, Henit Yanai, Iris Dotan, Subrata Ghosh and Marietta Iacucci in Therapeutic Advances in Gastroenterology</p
sj-docx-2-tag-10.1177_17562848211068659 – Supplemental material for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases
No full textSupplemental material, sj-docx-2-tag-10.1177_17562848211068659 for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases by Henit Yanai, Bella Ungar, Uri Kopylov, Tali Sharar Fischler, Irit Avni Biron, Jacob E. Ollech, Idan Goren, Manar Matar, Tsachi Tsadok Perets, Raanan Shamir, Iris Dotan, Shira Amir and Amit Assa in Therapeutic Advances in Gastroenterology</p
sj-docx-1-tag-10.1177_17562848211068659 – Supplemental material for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848211068659 for Risk of consecutive immunogenic failure in switchers of anti-tumor necrosis factor alpha among patients with inflammatory bowel diseases by Henit Yanai, Bella Ungar, Uri Kopylov, Tali Sharar Fischler, Irit Avni Biron, Jacob E. Ollech, Idan Goren, Manar Matar, Tsachi Tsadok Perets, Raanan Shamir, Iris Dotan, Shira Amir and Amit Assa in Therapeutic Advances in Gastroenterology</p
Advanced technology for assessment of endoscopic and histological activity in ulcerative colitis: a systematic review and meta-analysis.
Full text linkBackground
Advanced endoscopic technologies led to significant progress in the definition of endoscopic remission of ulcerative colitis (UC) and correlate better with histological changes, compared with standard endoscopy. However, while studies have assessed the diagnostic accuracy of endoscope technologies individually, there are currently limited data comparing between technologies. As such, the aim of this systematic review was to pool data from the existing literature and compare the correlations between endoscopy and histologic disease activity scores across endoscope technologies.
Methods
We searched PubMed and Embase until February 2021 for eligible studies reporting the correlation between endoscopy and histology activity scores in UC. Studies were grouped by endoscope technology as standard-definition white light (SD-WLE), high-definition white light (HD-WLE) or electronic virtual chromoendoscopy (VCE) and comparisons made between these groups.
Results
A total of = 27 studies were identified, of which = 12 were included in a meta-analysis of correlations between endoscopic and histological activity scores. Combining these studies identified considerable heterogeneity ( : 89-93%) and returned a pooled correlation coefficient () for the SD-WLE group of 0.74, which did not differ significantly from HD-WLE (: 0.65, = 0.521) or VCE (: 0.70, = 0.801). In addition, = 4 studies reported the accuracy of endoscopic activity scores on WLE and VCE to diagnose histological remission. Pooling these found significantly higher accuracy for VCE, compared with WLE [risk ratio: 1.13, 95% confidence interval (CI): 1.07-1.19, < 0.001].
Conclusion
Activity scores assessed using endoscopy are strongly correlated with activity on histology regardless of endoscopic technology. VCE seems to be more accurate in predicting histological remission than WLE. However, given the heterogeneity between the included studies, head-to-head trials are warranted to confirm these findings
Low-dose smoking resumption in ex-smokers with refractory ulcerative colitis
No full textUlcerative colitis (UC) is primarily a disease of non-smokers. Ex-smokers may have a more refractory disease course and anecdotal evidence in non-controlled clinical trials have suggested that smoking resumption, or the administration of nicotine, may ameliorate signs and symptoms of UC in ex-smokers. We report outcomes of ex-smokers with refractory UC who resumed low-dose cigarette smoking
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