221,164 research outputs found
Ceremony - Yang Zhang, Yuwei Zhang, Yan Zhao
No full textLL.M. graduatesYang Zhang, Yuwei Zhang, and Yan Zhao receive their hoods.https://scholarship.kentlaw.iit.edu/commencement_2013/1083/thumbnail.jp
Profile of Zhang Yan
No full textProfile of and interview with Zhang Yan, Gen. Manager, CITICSat and Chief Rep., Asiasa
Schizosthetus baixuelii Zhang, Xie & Yan 2024, sp. nov.
No full text<i>Schizosthetus baixuelii</i> Zhang, Xie <i>&</i> Yan sp. nov. <p>(Figures 1–17)</p> <p> <i>Material examined</i>. Female holotype, collected by Mr. Bai Xue-Li in decomposing pine litter, tourist area of Luoshan (114°10’ E –114°39’ E, 31°44’ N –32°19’ N, alt. 2,536 m), Tongxin County, Ningxia Hui Autonomous Region, China, June 9th, 2015. Paratypes, three females with the same collection data as the holotype. The holotype and all other specimens are deposited in the Academy of Military Medical Sciences, Beijing, China.</p>Published as part of <i>Zhang, Shuo, Xie, Lixia, Wang, Haoran, Dong, Minghang & Yan, Yi, 2024, Schizosthetus Athias-Henriot, 1982 (Mesostigmata: Parasitidae): the description of a new species from China, pp. 279-286 in Zootaxa 5403 (2)</i> on page 280, DOI: 10.11646/zootaxa.5403.2.6, <a href="http://zenodo.org/record/10561861">http://zenodo.org/record/10561861</a>
Re-education and Labor Camps in novels by Zhang Xianliang and Yan Lianke
No full textRe-education and Labor Camps in novels by Zhang Xianliang and Yan Lianke ABSTRACT: This paper is focused on two modern Chinese novels which are situated in a "re- educative" labor camp. Author analyzes novels Suffering is also Wisdom and Four Books and interprets these novels as a document created for the purpose of providing a truthful depiction of a specific historical era. In analysed novels can also be found apparent criticism of totalitarian regime, utopic communist ideology and pointing out issues related to the interpretation of modern Chinese history. The author uses literature in Czech, Chinese and English languages. KEYWORDS: modern Chinese novel, labor-camp fiction, Zhang Xianliang, Yan Liank
FIGURE 2. Astragalus taledensis P. Yan & H. Zhang. A. Habit, B. Inflorescence, C. Fruit, D. Seed, E. Wing, F. Standard, G. Keel, H. Calyx, I. Stamens, J in Astragalus taledensis, a new species of Leguminosae from Xinjiang, China
No full textFIGURE 2. Astragalus taledensis P. Yan & H. Zhang. A. Habit, B. Inflorescence, C. Fruit, D. Seed, E. Wing, F. Standard, G. Keel, H. Calyx, I. Stamens, J. Pistil. Drawing by Siqi Xie.Published as part of Zhang, Huan, Ren, Shanshan & Yan, Ping, 2021, Astragalus taledensis, a new species of Leguminosae from Xinjiang, China, pp. 199-204 in Phytotaxa 524 (3) on page 201, DOI: 10.11646/phytotaxa.524.3.4, http://zenodo.org/record/564934
Rationally Designed Hybridization Systems for Nucleic Acid Diagnostics and Sequence Analysis
No full textDetection of changes in a nucleic acid sequence is crucial in genomics research and precision medicine. With the advances of new generation’s of technology platforms, researchers have been able to study the fundamental causes of human diseases in DNA or RNA level, leading to optimal targeted treatment, real-time monitoring of disease progression, and ultimately early diagnosis and intervention before symptoms occur. Although people have been developing nucleic acid based assays for decades, the common methodology that people use in the design process of nucleic acid based assays are trial and error adjustment of probe or primer sequences and empirical optimization of buffer conditions. These methods offer quantitatively improvements of nucleic acid reaction behaviors (yield and specificity) to a certain degree, but are hard to achieve qualitative breakthroughs.
During my PhD, my main focus is how to use the “rational design” concept in nucleic acid technology development. Our lab has an extensive background in nucleic acid hybridization biophysics, which facilitates reliable and generalizable in silico assay and device design with little empirical optimization.
As demonstration, 4 technologies have been developed with 4 manuscripts to provide potential solutions for 4 different application fields:
1) DNA signaling and computing device
[1] Yan Helen Yan, David Yu Zhang and Lucia R. Wu. “Encoding multiple digital DNA signals in a single analog channel” manuscript in preparation.
2) Hybridization probe
[2] Juexiao Sherry Wang*, Yan Helen Yan* and David Yu Zhang. “Modular probes for enriching and detecting complex nucleic acid sequences.” Nature chemistry 9.12 (2017): 1222. *Equal contribution
3) Next generation sequencing
[3] Yan Helen Yan and David Yu Zhang. “Symbolic Sequencing of DNA and RNA Via Sequence Encoding.” manuscript in preparation.
4) Quantitative PCR
[4] Ping Song, Sherry X. Chen, Yan Helen Yan and David Yu Zhang. “Detecting and Identifying Low Fraction Conspecific DNA” in submission to Nature Methods. These works are not meant to be final, optimized designs for assays and devices, but rather demonstrations of the wide range of problems that can be solved with nucleic acid rational design
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