185,276 research outputs found

    Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

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    Chronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD

    Bishop Vasily Yao Fu\u27an

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    Bishop Vasily Yao Fu\u27an in Moscow. Moscow, Russia. B/W Image.https://digitalcommons.whitworth.edu/cmh_orthodox/1066/thumbnail.jp

    Bishop Vasily Yao Fu\u27an

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    Bishop Vasily Yao Fu\u27an. Beijing. B/W Photo.https://digitalcommons.whitworth.edu/cmh_orthodox/1065/thumbnail.jp

    A diluent for prolonged motility of ocean pout (Macrozoarces americanus L.) sperm

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    The present study describes a new semen diluent (diluent C) which prolongs the sustained motility of ocean pout sperm, a distinguishing feature of the sperm of internally fertilizing teleosts. Sperm motilities were compared in the new diluent (C), based on the ionic composition of ocean pout seminal plasma, vs. four other semen diluents (A, B, D and E) ordinarily used for extending the semen of external fertilizers. While sperm retained motility after extension of ocean pout semen in all of these diluents, motility was significantly reduced following sperm resuspension in diluents B and D. Since sperm motility remained high in diluent C, formulated to closely mimic the composition of ocean pout seminal plasma, it was selected for additional experimentation. Negative effects were observed on sperm motility after dilution (> 1:10) of ocean pout semen with diluent C, but sperm motility could be restored by replacement of the seminal plasma. Of practical importance for storage of ocean pout sperm at 4 degrees C, it was shown that semen dilution 1:3 in diluent C preserved sperm motility beyond 5 days. Although ocean pout sperm tolerate a fairly wide range of K+ levels (0-30 mmol/l), the best motility was observed from 10-20 mmol/l [K+], similar to the ionic levels found in seminal plasma. Finally, since no change in fertility of ocean pout sperm occurred following 1:3 dilution of semen in diluent C, we conclude that diluent C is an effective medium for in vitro artificial egg insemination and prolonged motility of ocean pout sperm. (C) 1999 Elsevier Science B.V. All rights reserved.PT: J; CR: BAYNES SM, 1981, J FISH BIOL, V19, P259 BILLARD R, 1992, J EXP ZOOL, V261, P122 BILLARD R, 1993, AQUAT LIVING RESOUR, V6, P67 CHAMBEYRON F, 1990, AQUACULTURE, V90, P345 CHAUVAUD L, 1995, ENVIRON BIOL FISH, V43, P341 COBB JLS, 1973, J FISH BIOL, V5, P587 ERDAHL AW, 1987, AQUACULTURE, V60, P311 ERDAHL AW, 1987, AQUACULTURE, V60, P323 GALLANT RK, 1993, THERIOGENOLOGY, V40, P479 GATTI JL, 1990, J CELL PHYSIOL, V143, P546 GOODALL JA, 1989, AQUACULTURE, V77, P243 OHTA H, 1996, AQUACULTURE, V142, P107 PAVLOV DA, 1994, AQUACULTURE, V122, P295 STOSS J, 1983, AQUACULTURE, V30, P229 SUQUET M, 1993, J FISH BIOL, V42, P509 WANG Z, 1997, FISH PHYSIOL BIOCHEM, V16, P77 YAO Z, 1995, MOL REPROD DEV, V42, P58 YAO Z, 1995, P 5 INT S REPR PHYS YAO ZX, 1995, AQUACULTURE, V130, P361 YAO ZX, 1995, J FISH BIOL, V47, P171; NR: 20; TC: 6; J9: AQUACULTURE; PG: 11; GA: 182MLSource type: Electronic(1

    Bishop Vasily Yao Fu\u27an

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    Bishop Vasily Yao Fu\u27an - formal portrait. Beijing. B/W Photo.https://digitalcommons.whitworth.edu/cmh_orthodox/1064/thumbnail.jp

    Prof. Th. W. Adorno and the author Hans Erich Nossack.

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    Prof. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB
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