70,741 research outputs found
Natural history and outcome in systemic AA amyloidosis
No full textBACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders. Little is known about the natural history of AA amyloidosis or its response to treatment.METHODS:We evaluated clinical features, organ function, and survival among 374 patients with AA amyloidosis who were followed for a median of 86 months. The SAA concentration was measured serially, and the amyloid burden was estimated with the use of whole-body serum amyloid P component scintigraphy. Therapy for inflammatory diseases was administered to suppress the production of SAA.RESULTS:Median survival after diagnosis was 133 months; renal dysfunction was the predominant disease manifestation. Mortality, amyloid burden, and renal prognosis all significantly correlated with the SAA concentration during follow-up. The risk of death was 17.7 times as high among patients with SAA concentrations in the highest eighth, or octile, (greater/equal 155 mg per liter) as among those with concentrations in the lowest octile (< 4 mg per liter); and the risk of death was four times as high in the next-to-lowest octile (4 to 9 mg per liter). The median SAA concentration during follow-up was 6 mg per liter in patients in whom renal function improved and 28 mg per liter in those in whom it deteriorated (P < 0.001). Amyloid deposits regressed in 60% of patients who had a median SAA concentration of less than 10 mg per liter, and survival among these patients was superior to survival among those in whom amyloid deposits did not regress (P=0.04).CONCLUSIONS:The effects of renal dysfunction dominate the course of AA amyloidosis, which is associated with a relatively favorable outcome in patients with SAA concentrations that remain in the low-normal range (< 4 mg per liter)
Visita de SS. MM. y AA. a Burgos. Palacio Muguiro, residencia de la Real Familia en la ciudad y propiedad de D. Juan Mugiro y Casi [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Visita de SS. MM. y AA. a Burgos. La Cartuja de Miraflores [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Valladolid, paso de SS. MM. y AA. bajo el arco de triunfo levantado en el Campo Grande [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Palais Royal de Segovie, dans la Castille Vieille [Material gráfico]= Het Koninglijk Hof van Segovia, in Oud-Castilien
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Vue du Château de Segovie par derriére [Material gráfico]= Het Kasteel van Segovia, zoo als het zelve zig van agteren vertoond
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Ryhiner-Kartensammlung / 5-10 La plus nouvelle, la plus exacte, et la plus grande carte de l'empire d'Allemagne : divisé en le royaume de Bohème, et les X. cercles; savoir, d'Autriche, Bourgogne, Bavière, l'electorat du Rhin, les Saxe superieure et inferieure, la Westphalie, la Souabe, la Franconie et le Rhin; avec la Suisse tout entière, les mers, iles, païs, etc. d'alentour : on y a aussi exactement marqué toutes les postes et les grands chemins, de même que les côtes, bancs de sables, brasses d'eau, etc : le tout dressé sur les lieux, et rectifié sur les nouvelles observations de Mess.rs de l'Academie royale des sciences et de celles des plus habiles geographes : dedié a tres-haut, tres-auguste et invincible monarque Charles VI. empereur des romains, soutien de la chrétienté
No full textpar son tres-humble et tres-soumis serviteur Pierre vander Aa, marchand libraireTitelkartusche oben links, Massstabs- und Legendenkartusche unten recht
Procession des pélerins à Compostelle [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Valladolid [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
Burgos, capitale de la Castille Vieille [Material gráfico]
No full textCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201
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