175 research outputs found
L.S. Vygotsky: Reading Anew. Part 1.
No full textThe article dwells on the earlier period of Vygotsky’s works before the time when the principles of the Cultural Historic Theory were formulated. His report on the 2nd Psycho-Neurologic Congress in 1924 as well as some adjacent works including “The historical sense of psychological crisis” are considered by the author as key moments. If to compare Vygotsky’s approach with I.P. Pavlov’s theory of conditioned reflex, V.M. Bechterev’s reflexology and K.N. Kornilov’s reactology,from one side, and psychology, from the other, it reveals Vygotsky’s determination to restructure psychology on the objective basis. In his opinion this implies the turn of psychology to higher forms of human’s behavior, actually, to human activity. In these methodological changes of Vygotsky’s views one can trace certain relations of Vygotsky’s early works with P.Ya. Galperin’s theoretical survey on subject and method of psychology.</p
On the Psychological Mechanism of Ontogenetic Development in the Context of Developmental and Educational Psychology
No full textAbstractThe article offers the author's view of the psychological mechanism for the development of a child. It is regarded as the process of ripening and resolving of fundamental contradictions between the child's system of relations and modes of activity acquired by him. Underlined by the author is the objective nature of ontogenetic development as well as the role of child's motivation as a driver of necessary transformations of the child's activity leading to his psychological growth. The similarities and differences between the author's approach and that of D. B. Elkonin are precisely traced. The author’ arguments are supported by a lot of evidence from the theory and practice of developmental and educational psychology with special focus on the role of social institutions
К вопросу о роли Конституционного Суда Российской Федерации в системе реализации принципов народовластия в России
No full textThe article is devoted to the role of the constitutional court of the Russian Federation in the system of implementation of constitutional principles. The author considers the acts of the constitutional court and their impact on both the biscuits the power of the people .The article provides examples that affect citizens electoral rights.Статья посвящена роли Конституционного суда Российской Федерации в системе реализации конституционных принципов. Автором рассматриваются акты Конституционного суда и их влияние на обе печение власти народа .В статье приведены примеры, затрагивающие избирательные права граждан
Molecular Mechanisms Regulating RNA Polymerase II Pausing During Gene Activation
No full textRNA Polymerase II (Pol II), the enzyme that transcribes all messenger RNAs (mRNAs) has another activity by pausing at gene promoters. The paused Pol II generates short 5’-capped RNAs of about 50 nucleotides in length. Much is known about Pol II pausing including its prevalence across the genome. But, the molecular mechanisms that are involved in regulating Pol II pausing and its roles in gene regulation are yet to be fully explored. In this study, I have investigated the molecular mechanisms that regulate dynamics of Pol II pausing in response to gene activation.
The main goal of this study was to determine how cells respond to stimuli by altering Pol II pausing states. To this end, we characterized changes in Pol II pausing in MCF-7 human breast cancer cells, using two distinct stimuli, heat shock and Trichostatin A (TSA), a histone deacetylase inhibitor. Two genes SNAI1, a master regulator of epithelial to mesenchymal transition, and HSPA1B (heat shock protein 70), a master regulator of heat shock response, show mRNA upregulation upon treatment with both stimuli. To determine changes in Pol II pausing and its dynamics in response to gene activation, I have used permanganate footprinting for single gene analysis, and short-capped RNA sequencing (scRNA-seq) for genome-wide analysis. I have shown that, upon activation, paused genes can retain Pol II pausing and non-paused genes can acquire Pol II pausing. Further, I observe that genes such as HSPA1B, undergo pause release during heat shock activation but SNAI1 does not. In addition, I have shown that the turnover of the paused Pol II complex changes in a stimulus-specific manner, indicating that the release of paused Pol II is sensitive to the nature of the stimulus. To investigate the rate of turnover of the paused complex, I used a specific inhibitor of a general transcription factor TFIIH, Triptolide and measured the residence time of the Pol II complex at the paused site. Genome-wide analysis of Pol II turnover demonstrates that not all genes respond the same way to heat shock. This project describes a novel mechanism for regulation of transcription during gene activation in human cells during responses to environmental stresses
(Table 2) Percentage of heavy clastic minerals from different Deep-Sea Drilling Project cores
No full text(Table 2) Percentage of heavy clastic minerals from different Deep-Sea Drilling Project core
(Table 1) Chemical composition from different Deep-Sea Drilling Project samples
No full text0.05 mm fraction (selected by wet sieving) was analysed because the sample volume was not sufficiently large for both chemical and mineralogical analyses. As a result of sieving, the seawater salts were washed out of the samples. In other cases natural sediments were analyzed
(Table 3) Chemical analyses from different Deep-Sea Drilling Projects
No full text(Table 3) Chemical analyses from different Deep-Sea Drilling Project
Relativistic splitting of surface states at Si-terminated surfaces of the layered intermetallic compounds RT2 Si2 (R=rare earth; T=Ir, Rh)
No full textWe present an effective model for surface states at the Si-terminated (001) surface of ternary rare earth (R) intermetallic compounds RT2Si2 with the transition metal element T = Ir or Rh. The model is based on a fully ab initio derivation of the relativistic k⋅p Hamiltonian and is thereby capable of accurately reproducing the spin polarization of the spin-orbit split surface states, which is very different from the classical Rashba effect. The reliable treatment of spin in our model enables a predictive analysis of the effect of magnetic exchange interaction of the surface-state electrons with ferromagnetically ordered 4f moments of the subsurface rare-earth layer in the magnetic phases of the
RT2Si2 compounds.This work was supported by the Spanish Ministry of Science, Innovation and Universities (Project No. FIS2016-76617-P).Peer reviewe
wave functions
No full textWe present a method to microscopically derive a small-size k⋅p Hamiltonian in a Hilbert space spanned by physically chosen ab initio spinor wave functions. Without imposing any complementary symmetry constraints, our formalism equally treats three- and two-dimensional systems and simultaneously yields the Hamiltonian parameters and the true Z2 topological invariant. We consider bulk crystals and thin films of Bi2Se3,
Bi2Te3, and Sb2Te3. It turns out that the effective continuous k⋅p models with open boundary conditions often incorrectly predict the topological character of thin films.This work was supported by the Spanish Ministry of Economy and Competitiveness MINECO (Project No. FIS2013-48286-C2-1-P) and Saint Petersburg State University (Grant No. 15.61.202.2015).Peer reviewe
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