184 research outputs found
The multi-airport ground-holding problem in air traffic control
No full textIncludes bibliographical references (p. 33-34).Supported by Charles S. Draper Laboratory. Second author partially suported by the National Science Foundation with a Presidential Young Investigator Award. DDM-9158118Peter B. Vranas, Dimitris J. Bertsimas, Amedeo R. Odoni
Correction to: A multilevel longitudinal study of obsessive compulsive symptoms in adolescence: male gender and emotional stability as protective factors
No full textAbstract The original version of this article unfortunately contained a mistake in the author name. The co-author’s name should be Dimitris Dikeos instead of Dimitris Dikaios
Regulation of the p53 Tumor-Suppressor Protein by Ubiquitin and Ubiquitin-Like Molecules
No full textIsolation of NEDDylated proteins in human cells
No full textIdentification of substrates for post-translational modification with ubiquitin and ubiquitin-like molecules is a key in our understanding of the role of this modification in the regulation of biological processes. The ubiquitin-like molecule NEDD8 plays a vital role in cell growth, viability, and development. In this chapter, we describe a method for efficient isolation and detection of NEDDylated proteins in human cells
Regulation of the p53 Tumor-Suppressor Protein by Ubiquitin and Ubiquitin-Like Molecules
No full textNovel substrates and functions for the ubiquitin-like molecule NEDD8
No full textGenetic experiments have established an important role for the ubiquitin-like molecule NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) in the regulation of cell growth, viability and development. It is therefore essential to identify the molecular targets for the pathway. Until recently, the cullin family of proteins was characterized as the only substrates for NEDDylation. However, through either direct biological approaches or the use of proteomics, it is now evident that the NEDD8 proteome is more diverse than thought previously. The present review describes the biological significance of NEDDylation for the novel identified substrates and the emerging evidence for the co-operation between the ubiquitin and NEDD8 pathways to control protein function
Governance networks in politics
No full textIn this chapter Dimitris Christopoulos provides an overview of governance networks in politics. Governance is examined both as a generative process to political structure as well as the product of political relations. The author outlines key parameters for capturing network properties of political action with a particular focus on political power and decision making. Of particular interest are the mechanisms through which agent relations affect power structures and the impact this has on governance outcomes. The key claim is that governance network topology is shaped by structural parameters, such as centralization levels as well as political structure, such as the rules of interaction among agents. The author argues that studies of governance ideally combine a focus on the quality of agent interactions, their political resources, resource transfers, power hierarchies, and actor values.</p
Example calculation sheet for Thermal Cone Penetration Test (T-CPT)
No full textThis is an example calculation sheet for the Thermal Cone Penetration Test (T-CPT), based on the paper tentatively recommended for publication on 22 May 2018: Journal: Geotechnique; Article number: 17-P-214R1; Title: Interpreting and validating the Thermal Cone Penetration Test (T-CPT); Author(s): Philip J Vardon, Dimitris Baltoukas, Joek Peuche
Does Culture Matter? The Relevance of Culture in Politics and Governance in the Euro-Mediterranean Zone. ZEI Discussion Paper: 2002: C 111
No full text[Table of Contents]: Culture and Governance in the Mediterranean – A Rationale and Overview, by Indra de Soysa and Peter Zervakis; The Relevance of Culture in Democratic Governance – Lessons from the Western Hemisphere, by Lawrence E. Harrison; Culture in Politics and Governance – European Experiences, by Klaus von Beyme; Penser L’Espace Mediterranean, by Mohammed Arkoun; Muslim and Western Civilization – Is Co-Prosperity and Peace Possible?, by Erich Weede; Political Culture and Democracy in Turkey, by Ergun Özbudun; The Crisis of Political Culture in the Arab World – A Conflict of Paradigms, by Paul Salem; Euro-Mediterranean Formations – Cultural Imperatives of System Change, by Dimitris K. Xenakis and Dimitris Chryssochoou; Cross-cultural Currents in the Mediterranean – What Prospects, Stephan Calleya; Politics and Governance in the Mediterranean, by Franck Biancheri; The Mediterranean - New Directions of Research and Policy-Making, by Ludger Kühnha
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe
No full textThe ubiquitin-like protein NEDD8 is highly conserved in eukaryotes, from man to Schizosaccharomyces pombe. NEDD8 conjugation to cullin proteins is a prerequisite for cullin based E3 ubiquitin ligase activity, and essential for S. pombe viability. Here, we have performed alanine scanning mutagenesis of all conserved surface residues and show that the majority of essential residues were located around the hydrophobic patch and the C-terminus. However, we further identified essential residues not previously reported to be involved in ubiquitin ligase regulation that importantly do not prevent Ned8p conjugation. We also find that mutation of all conserved lysine residues in Ned8p, did not affect yeast viability, suggesting that mono-neddylation is sufficient for yeast viability under most conditions
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