1,722,382 research outputs found
San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review
No full textInflammatory disorders underlie varieties of human diseases. San-Huang-Xie-xin-Tang (SHXXT), composed with Rhizoma Rhei (Rheum palmatum L), Rhizoma Coptidis (Coptis chinensis Franch), and Radix Scutellaria (Scutellaria baicalensis Georgi), is a famous formula which has been widely used in the fight against inflammatory abnormalities. Mutual reinforcement is one of the basic theories of traditional Chinese medicine. Here this article reviewed and analyzed the recent research on (1) How the main constituents of SHXXT impact on inflammation associated signaling pathway molecules. (2) The interaction between the main constituents and efflux pumps or intestinal transporters. The goal of this work was to, (1) Provide evidence to support the theory of mutual reinforcement. (2) Clarify the key targets of SHXXT and suggest which targets need further investigation. (3) Give advice for the clinical use of SHXXT to elevated the absorption of main constituents and eventually promote oral bioavailability. We search literatures in scientific databases with key words of "each main SHXXT constituent," in combination with "each main inflammatory pathway target molecule" or each main intestinal transporter, respectively. We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. We conclude, (1) The synergistic effect of constituents at both levels confirm the mutual reinforcement theory of TCM as it is proven in this work. (2) The effect of main constituents on downstream targets in nuclear need more further investigation. (3) Drug elevating the absorption of rhein, berberine and baicalein can be employed to promote oral bioavailability of SHXXT
CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS
Full text linkBackground: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored.Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities.Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.Keywords: Bao-Xin-Tang, cardioprotective, infarction size, anti-inflammatory, anti-oxidativ
Investigating the multi-target effects of Yang Xin Tang on Alzheimer’s disease- related signaling pathways
No full textYang Xin Tang (YXT) is a traditional Chinese medicine (TCM) prescription that had been clinically used for treating dementia for a long history. To evaluate the anti-AD properties of YXT and its selected herbal components, we examined their effects on known AD therapeutics targets. Anti-AD capacity is indicated by the ability of these herbal extracts to (i) activate extracellular signal-regulated kinases (ERK) and cAMP responsive element binding protein (CREB); (ii) modulate calcium mobilization; and (iii) inhibit cyclooxygenases (COX)-1 and COX-2 activities. Our results suggested that YXT and its selected herbal components possess multiple regulatory effects on these molecular targets and signaling pathways underpin AD pathology, lending credence to its potential use as an alternative medicines for treating AD
sj-docx-1-psp-10.1177_01461672221076970 – Supplemental material for What Drives Daily Perseverance and Passion? Grit, Conscientiousness, and Goal Pursuit Experiences
No full textSupplemental material, sj-docx-1-psp-10.1177_01461672221076970 for What Drives Daily Perseverance and Passion? Grit, Conscientiousness, and Goal Pursuit Experiences by Wen Jiang, Xin Tang, Jingyan Ye and Jiang Jiang in Personality and Social Psychology Bulletin</p
sj-docx-2-psp-10.1177_01461672221076970 – Supplemental material for What Drives Daily Perseverance and Passion? Grit, Conscientiousness, and Goal Pursuit Experiences
No full textSupplemental material, sj-docx-2-psp-10.1177_01461672221076970 for What Drives Daily Perseverance and Passion? Grit, Conscientiousness, and Goal Pursuit Experiences by Wen Jiang, Xin Tang, Jingyan Ye and Jiang Jiang in Personality and Social Psychology Bulletin</p
sj-docx-1-pac-10.1177_18344909231185381 - Supplemental material for Killing the cats or satisfying the human? The role of epistemic curiosity in adolescents’ multidimensional well-being
No full textSupplemental material, sj-docx-1-pac-10.1177_18344909231185381 for Killing the cats or satisfying the human? The role of epistemic curiosity in adolescents’ multidimensional well-being by Tian Li, Haoyan Huang, Jia Liu and Xin Tang in Journal of Pacific Rim Psychology</p
DS_10.1177_0363546518782705 – Supplemental material for Low-Molecular-Weight Heparin for the Prevention of Venous Thromboembolism in Patients Undergoing Knee Arthroscopic Surgery and Anterior Cruciate Ligament Reconstruction: A Meta-analysis of Randomized Controlled Trials
No full textSupplemental material, DS_10.1177_0363546518782705 for Low-Molecular-Weight Heparin for the Prevention of Venous Thromboembolism in Patients Undergoing Knee Arthroscopic Surgery and Anterior Cruciate Ligament Reconstruction: A Meta-analysis of Randomized Controlled Trials by Jing Zhu, Hai Jiang, Brandon Marshall, Jian Li and Xin Tang in The American Journal of Sports Medicine</p
Modern Applications of Modified Ban Xia Xie Xin Tang and Their Development
No full textTraditional Chinese medicine (TCM) classic formulae have evolved over hundreds of years; however, their applications and modifications can be further developed. The classic formula Ban Xia Xie Xin Tang (Pinellia Decoction to Drain the Epigastrium; BXXXT), which was originally prescribed by
Zhang Zhong-Jing in the Han dynasty (150–219), can be modified and used flexibly in treating various abdominal disorders. In the Qing dynasty (1644–1911), Wu Ju-Tong (1758–1836) wrote the book Wen Bing Tiao Bian (Systematised Identification of Warm Pathogen Diseases), outlining his eight modifications to BXXXT based on Ye Tian-Shi’s (1667–1746) clinical applications of BXXXT and its patterns. Ye applied BXXXT in two main ways. The first involved the use of bitter, pungent, dispersing and purging herbs to treat damp heat; the second was used to purge jue yin and unblock yang ming in order to treat various symptoms caused by Liver wood attacking Stomach earth. Wu followed Ye’s methodology and developed eight modifications to BXXXT.
These can treat summer heat-damp (shu shi), lurking summer heat (fu shu) and damp-warm (shi wen) conditions. They can also treat jue yin Liver conditions or Liver Qi attacking Stomach patterns. This article discusses the use of Wu Ju-Tong’s eight modifications. Modern clinical cases
including nausea, vomiting, abdominal distension, stomach ache, diarrhoea and infertility have been used as examples to illustrate the flexible use of BXXXT
The Use of San-Huang-Xie-Xin-Tang Reduces the Mortality Rate among Breast Cancer Patients
No full textGlobally, breast cancer is the most common cause of cancer deaths. In Taiwan, it is the most prevalent cancer among females. Since San-Huang-Xie-Xin-Tang (SHXXT) exerts not only an anti-inflammatory but an immunomodulatory effect, it may act as a potent anti-tumor agent. Herein, the study aimed to explore the influence of SHXXT and its constituents on the mortality rate among breast cancer patients in Taiwan regarding the component effect and the dose–relationship effect. By using the Taiwan National Health Insurance (NHI) Research Database (NHIRD), the study analyzed 5387 breast cancer patients taking Chinese herbal medicine (CHM) and 5387 breast cancer patients not using CHM. CHM means SHXXT and its constituents in the study. The Kaplan–Meier method was utilized to determine the mortality probabilities among patients. Whether the CHM influences the mortality rate among patients was estimated by Cox proportional hazard regression analysis. The use of CHM could lower the cancer mortality rate by 59% in breast cancer patients. The protective effect was parallel to the cumulative days of CHM use and the annual average CHM dose. In addition, the mortality rate was lower in patients who used SHXXT compared to those who only used one of its constituents. SHXXT and its constituents were all promising therapeutic weapons against breast cancer
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