1,943,210 research outputs found
Xia Guan, 49
No full textXia Guan, a Palo Alto resident who worked at Gilead Sciences, has died. She was 49
XIA Data Analysis Tools
No full text<p>This preliminary release describes the XIA digitizer data format.</p>
Who Mismanages Student Loans, and Why?
No full textWho Mismanages Student Loans, and Why?
Kimberly Cornaggia, Pennsylvania State University;
Han Xia, University of Texas at Dallas
The mechanism underlying activation of factor IX by factor XIa
No full textFactor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXaβ (fIXaβ). There is considerable interest in fXIa as a therapeutic target because it contributes to thrombosis, while serving a relatively minor role in hemostasis. FXI/XIa has a distinctly different structure than other plasma coagulation proteases. Specifically, the protein lacks a phospholipid-binding Gla-domain, and is a homodimer. Each subunit of a fXIa dimer contains four apple domains (A1 to A4) and one trypsin-like catalytic domain. The A3 domain contains a binding site (exosite) that largely determines affinity and specificity for the substrate fIX. After binding to fXIa, fIX undergoes a single cleavage to form the intermediate fIXα. FIXα then rebinds to the A3 domain to undergo a second cleavage, generating fIXaβ. The catalytic efficiency for the second cleavage is ~ 7-fold greater than that of the first cleavage, limiting fIXα accumulation. Residues at the N-terminus and C-terminus of the fXIa A3 domain likely form the fIX binding site. The dimeric conformation of fXIa is not required for normal fIX activation in solution. However, monomeric forms of fXI do not reconstitute fXI-deficient mice in arterial thrombosis models, indicating the dimer is required for normal function in vivo. FXI must be a dimer to be activated normal by the protease fXIIa. It is also possible that the dimeric structure is an adaptation that allows fXI/XIa to bind to a surface through one subunit, while binding to its substrate fIX through the other
Xia Guan, February 4, 1970 - June 18, 2019
No full textXia Guan, beloved mother, wife, and daughter, passed away on June 18, 2019, after 5 years of battle with cancer
Shanghai wu yan xia: san mu hua ju.
No full text夏衍著."五四以来話剧剧本选"--封面.Xia Yan zhu."Wu si yi lai hua ju ju ben xuan"--Feng mian
Conocephalus (Conocephalus) sulcifrontis Xia et Liu 1992
No full textConocephalus (Conocephalus) sulcifrontis Xia et Liu, 1992 (Figs. G) Conocephalus sulcifrontis Xia et Liu, 1992: 163 Distribution: China (Shanghai, Jiangsu).Published as part of Zhou, Min, Bi, Wen-Xuan & Liu, Xia-Wei, 2010, The genus Conocephalus (Orthoptera, Tettigonioidea) in China, pp. 49-60 in Zootaxa 2527 on page 52, DOI: 10.5281/zenodo.19645
Assessment of Self-Archiving in Institutional Repositories: Depositorship and Full-Text Availability
No full textThis research evaluates the success of open access self-archiving in several well-known institutional repositories. Two assessment factors have been applied to examine the current practice of self-archiving: depositorship and the availability of full text. This research discovers that the rate of author self-archiving is low and that the majority of documents have been deposited by a librarian or administrative staff. Similarly, the rate of full-text availability is relatively low, except for Australian repositories. By identifying different practices of self-archiving, repository managers can create new strategies for the operation of their repositories and the development of archiving policies
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