14,657 research outputs found
Tim McConico and Emil Jones
No full textPhotograph shows Tim McConico and Emil Jones, residents of Peyton (later Board House), Blanco County, Texas, smoking cigars as they pose with bottle of whiskey
Blink & Caution by T. Wynne-Jones
No full textWynne-Jones, Tim. Blink & Caution. Somerville: Candlewick Press, 2011. Print. Tim Wynne-Jones\u27 new novel is a tightly-paced thriller, featuring two strong and realistic characters with which older adolescent readers will engage. It tells the story of Brent Conroy (or Blink) and Kitty Pettigraw (Caution), two teenagers who are living marginal lives. The narrative shifts back and forth between the story of Blink, told in the second person with a unique rhythm and voice, and that of Caution, a more straight-forward third-person narrative. Blink and Caution live parallel lives, each occupying a precarious living situation—Blink living on the street and Caution with her drug dealer boyfriend; each character has chosen this situation in order to run from their individual personal tragedies, leaving them both open to abuse and other troubles. Blink\u27s story is driven by his discovery of the scene from where Jack Niven, the CEO of a major mining company, was apparently kidnapped; Blink steals Niven’s cell phone, and begins a conversation with Niven’s daughter, who pleads with Blink to help her solve the mystery. Blink soon crosses paths with Caution, who is herself on the run from her boyfriend after stealing thousands of dollars from him, in retribution for his cheating. Together, the two work to solve the kidnapping, and the novel continues on its fast pace. The characters are unusual and yet believable, as Wynne-Jones writes them to a depth of development not always seen in other YA novels. The opening chapter focuses on Blink, and this unusual use of the second-person prompts an immediate engagement with the story, particularly for strong readers who like a challenge. The ending ties together perhaps too neatly; on the other hand, some readers may find this to be a relief after the unrelenting pace of the novel’s narrative drama.Highly recommended: 4 out of 4 stars Reviewer: Allison SivakAllison is the Assessment Librarian at the University of Alberta Libraries. She is currently pursuing her PhD in Library and Information Studies and Elementary Education, focusing on how the aesthetics of information design influence young people’s trust in the credibility of information content.
Interview with Tim Jones
No full textTim Jones, Personal Accounts Delivery Authority and NEST CEO (2007-2015) talks about the creation of a national pensions savings scheme (currently known as National Employment Savings Trust) and challenges facing the implementation
Transplant
No full textTransplant is a large-scale photographic sound installation. Photographer Tim Wainwright and sound artist John Wynne have produced this thought-provoking and unique work after spending a year as artists-in-residence at Harefield Hospital, one of the world’s leading centres for heart and lung transplantation. Funded by Arts Council England and working with rb&hArts, they photographed and recorded patients, the devices they were attached to or had implanted in them, and the hospital itself.
Transplant is also a book, edited by Victoria Hume, comprising a collection of essays with a wide range of perspectives on the Transplant project and the wider issues it raises. It includes a 35-minute DVD by John Wynne and Tim Wainwright.
A related output is Hearts, Lungs and Minds, a half-hour composed documentary, commissioned for BBC Radio 3. More information is available at: http://www.sensitivebrigade.com and /Hearts,Lungs&Minds.htm http://ualresearchonline.arts.ac.uk/709/
Visitation
No full text© the artist.Medium: etchingMedium: aquatintprintsSigned "Tim Jones" (l.r. ) udner image; dated "94" (l.r. ) under image"Visitation" [1996.2116.000.000], Jones, TimArtist and Role: Jones, Tim, ArtistExtent: sheet 38 x 56, Plate 25.7 x 35.
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
No full textThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
Transplant (excerpt)
No full textBook chapter and 22-minute excerpt from the video Transplant, first published in the book, Transplant, edited by Victoria Hume.
This video makes use of photographs and audio recordings collected by John Wynne and Tim Wainwright during their year as artists-in-residence at Harefield Hospital, one of the world’s leading centres for heart and lung transplantation. Moving back and forth between documentation and an abstraction, the video piece provides a unique insight into the intense and fascinating experience undergone by the most vulnerable of patients.
Through all the differences and similarities of sound and vision, seeing and hearing, looking and listening, a rapprochement emerges in the collaboration between Wainwright and Wynne. Meaning arises out of fades and overlaps, sudden appearances and vanishings, fusing and disparity. Distinctions of the senses are less important than their indivisibility. Are we seeing or hearing, and how much of either perception is a consequence of the other? (David Toop
Woods with books
No full textMedium: wood engravingsigned and dated."Woods with books" [2013.0006.000.000], Jones, TimArtist and Role: Jones, Tim,Extent: blockExtent: shee
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