21 research outputs found
Avoiding Sour Grapes and Bitter Hops: How Wisconsin Laws Can Nurture the Local Wineries and Breweries that Drive Regional Economies
No full textThe purpose of this study is to explore how Wisconsin laws and regulations affect local wineries and breweries. In particular, this research examines how these laws impact local economies via the multiplier effect, a phenomenon in which money spent by local patrons and tourists creates jobs and drives consumption. This research also explores how these local businesses navigate the laws that govern them. Since a lot of the laws affecting these businesses were originally created following prohibition in 1933 -- when alcohol production was virtually synonymous with large volume breweries -- the operation of small local breweries and wineries often do not fit well within the historic context of existing legislation. The methodology used to conduct this study was one-on-one interviews with local winery and brewery owners in Central Wisconsin. To this end, we collected first hand perspectives on what it is like operating a small business under these laws and how they are affected both positively and negatively. Overall, Wisconsin laws could do more to drive local economics in the beer and wine sector, thereby contributing to the
economic success of local communities
Empowering Wisconsin Communities from Within: Harnessing Asset-Based Community Development (ABCD) for Sustainable, Locally-Driven Progress
No full textTraditionally, community development has followed a top-down approach in which decisions are made by city officials without adequate input from the people most directly affected by the outcomes. While well-intentioned, this approach often results in solutions that are not fully aligned to the local context or needs. Our Wisconsin communities deserve better. Using a case study methodology, this paper explores how Wisconsin communities can use an Asset-Based Community Development (ABCD) framework to better achieve sustainable, locally-driven progress. In particular, this research found that successful communities use ABCD to leverage seven unique capitals: natural, cultural, human, social, political, financial, and built. Ultimately, this study underscores the transformative potential of ABCD for community development by demonstrating that thoughtful attention to the seven capitals can pave the way towards a more inclusive, empowered, and sustainable future for Wisconsin Communities
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Assimilating into the transnational: Examining transnational identity in global cities through immigrant narratives
No full textAs cities become more globalized due to technological advances and increasingly interconnected flows of humans, capital, and goods, movement of people into new spaces has raised questions about belonging and identity within a global system of national boundaries. Ideas about immigration and assimilation have fluctuated throughout modern history, often on a scale between liberal ideas of cosmopolitanism and modes of belonging that favor national identity as a defining characteristic of community. This thesis explores immigrant narratives written by transnational individuals in the late 20th and early 21st century for the purpose of reconceptualizing belonging, identity, and assimilation in increasingly transnational urban spaces. By establishing a framework within which postcolonial theories of hybridized identity such as those put forth by Homi Bhabha and Gloria Anzaldúa are applied to the work of urban theorists like Michael Peter Smith and Sassia Sasken, this thesis pushes against the notion of assimilation as working toward “sameness,” and asks readers to consider the ways in which transnationality and globalization complicate notions of belonging and community-building. Rather than thinking of assimilation as a process of acquiring national membership, I argue that membership in the transnational world should be considered locally within the communities in which individuals live and operate as a mode of the sort of civic citizenship described by urban theorist Benjamin Barber. Within the following chapters, the city provides a locus for the argument that true belonging and “assimilation” are achieved through engaging transnational identity and adaptability as a mode of moving through the transnational urban. Chapter one focuses on the transnational flexibility of individuals in the works of Nigerian author Chimamanda Adichie. Chapter two challenges the notion of assimilation as developing a fixed identity based on cultural background through Chang-rae Lee’s Native Speaker. Chapters three and four look at hybridized identity within There There by Tommy Orange and The Brief Wondrous Life of Oscar Wao by Junot Díaz. These chapters explore transnational spaces more broadly by applying Deleuze and Guattari’s theory of smooth and striated space to describe the impacts of hegemonic systems on individuals who resist assimilation into the socioeconomic systems imposed on them by the nations in which they move.EnglishCollege of Liberal Art
Evaluation of Oregon's Relief Nursery Program
No full textTitle from PDF title page (viewed on December 3, 2021).Covers OCLC #1287101744, OCLC #1287102239, and OCLC #1050366179.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
The development of ovine placental lactogen deficient pregnancies
No full text2014 Fall.Includes bibliographical references.Intrauterine growth restriction (IUGR) results in significant fetal and neonatal mortalities and morbidities. Additionally, infants surviving IUGR experience increased incidence of heart disease, diabetes, hypertension and stroke during adulthood. A major placental secretory product, placental lactogen (PL), is found at high levels in maternal and fetal circulation, and is significantly reduced in both human and sheep IUGR pregnancies. While the exact function of PL has not been defined for any species, it is thought to modulate the mobilization of maternal nutrients to the fetus. Recently, the development of lentiviral-mediated expression of short hairpin RNA (shRNA) within sheep conceptuses has provided a means of examining placental gene function in sheep. The objective of this research was to generate ovine PL (oPL) deficient sheep pregnancies using lentivirus targeting the degradation of oPL mRNA, in order to assess the function of PL during pregnancy. We hypothesize that oPL deficiency during pregnancy will lead to IUGR near term. To test our hypothesis a preliminary study was conducted to evaluate the in vivo efficacy of lentiviral-oPL targeting vectors in the sheep placenta at 55 days gestational age (dGA). Efficiency of oPLmRNA degradation was first measured in vitro using twelve promoter-targeting sequence combinations, tested in three cell lines overexpressing oPL. Two oPL target sequences (tg2 and tg6) were used, as either shRNA or shRNAmiR (microRNA mimic) sequences. Subsequently, three lentiviral constructs; hLL3.7 tg6 (human U6 promoter expressing oPL tg6 shRNA), hEF-1 tg2 (human elongation factor-1α promoter expressing oPL tg 2 shRNAmiR) and oPGK tg6 (ovine phosphoglycerate kinase-1 promoter expressing oPL tg 6 shRNAmiR), were selected to be tested in vivo. Day 9 blastocysts were harvested from naturally mated donor ewes, infected with one of the lentiviral constructs, and 2 to 3 blastocysts were surgically transferred to recipient ewes. At 55 dGA, uterine vein (UtV) blood and placental tissues were collected for analysis of oPL expression, and compared to naturally mated controls (NMC). Based on a 95% confidence interval created from UtV oPL concentrations in NMC pregnancies (n=4), 3 out of 4 hLL3.7 tg6 pregnancies, 3 out of 4 hEF tg2 pregnancies and 4 out of 4 oPGK tg6 pregnancies were classified as responder pregnancies. Compared to NMC pregnancies, UtV oPL concentrations were significantly reduced (P≤0.05) in responder pregnancies. While we hypothesized that oPL deficiency will result in IUGR near-term, at 55 dGA there were no differences in fetal weights. To test our overall hypothesis, we generated 8 hEF-1-SC (human elongation factor-1α promoter expressing scrambled control shRNAmiR), 9 hEF-1 tg2, 7 hEF-1 tg6 (human elongation factor-1α promoter expressing oPL tg6 shRNAmiR) and 9 hLL3.7 tg6 singleton pregnancies that were harvested at 135 dGA. Based on two standard deviations below the mean placental weight of the hEF-1 SC pregnancies, 2 out of 7 hEF-1 tg6 pregnancies and 6 out of 9 hLL3.7 tg6 pregnancies were classified as tg6 responder pregnancies (tg6). Tg6 pregnancies resulted in significantly decreased (P≤0.05) oPL mRNA concentrations, placental weight and fetal body weight compared to the controls at 135 days of gestation. These data confirm the effect of lentiviral-oPL targeting vectors and suggest that oPL plays a significant role in early placental development. Interestingly, we also observed that tg6 pregnancies had significantly increased (P≤0.05) placental efficiency relative to controls, which may function as a coping mechanism to maintain pregnancy in the face of oPL deficiency. Uterine artery to uterine vein glucose gradients were also increased (P≤0.05) in tg6 pregnancies compared to controls, which may be indicative of increased glucose uptake by the placenta in order to maintain function. Further analysis revealed that circulating fetal insulin tended to be decreased in the umbilical artery (P≤0.10) of tg6 fetuses relative to control fetuses, thus supporting a role for oPL in altering fetal insulin production. Finally, mRNA concentrations of insulin-like growth factors (IGF) -I and -II, and insulin-like growth factor binding proteins (IGFBP) -2 and -3 were significantly reduced (P≤0.05) in fetal liver tissue of tg6 fetuses compared to the controls. While this could be an indirect result of IUGR, oPL may well induce the expression of fetal insulin-like growth factors during in utero development. Based on these results, our hypothesis that oPL deficiency during gestation would result in intrauterine growth restriction appears correct. Surprisingly, it appears that oPL may have its greatest impact during early pregnancy when the placenta is developing, however the presence of adequate oPL is likely to be important throughout gestation for healthy fetal growth
Health-related quality of life after major extremity trauma: qualitative research with military service members and clinicians to inform measurement of patient-reported outcomes
No full textThis article was originally published in Quality of Life Research. The version of record is available at: https://doi.org/10.1007/s11136-025-03915-0.
© The Author(s) 2025.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose
The purpose of this study was to understand health-related quality of life (HRQOL) factors for adults who experience major extremity trauma, including limb preservation and amputation, to guide the selection and creation of patient-reported outcome (PRO) measures.
Methods
A thematic content qualitative analysis was used to study service members (SMs) with a history of major extremity trauma and clinical providers with expertise in limb trauma, limb loss, and limb preservation/reconstruction. Focus groups were conducted at three Military Treatment Facilities and one Department of Veterans Affairs Medical Center.
Results
Fifty-six SMs and 34 clinicians participated. Thirty-six percent of focus group comments were coded under Physical Health, 31% Emotional Health, and 28% Social Participation. These results were largely consistent across clinicians and SMs, and clinical subgroups, with a few exceptions such as the relevance of fine motor tasks and prosthetic devices for SMs with upper extremity injury/limb loss, and orthotic devices for SMs with limb preservation/reconstruction.
Conclusion
Many HRQOL topics identified are shared with existing general PRO measures—including pain, physical function, anxiety, depression, anger, positive affect and well-being, fatigue, social participation, and loneliness—as well as rehabilitation-focused PRO measures—such as resilience, grief/loss, stigma, self-esteem, mobility, fine motor functioning, self-care, and independence. This qualitative research can be used to inform domains of HRQOL in need of new PRO measures for this population, including satisfaction with orthosis/prosthesis, satisfaction with physical abilities/athleticism, body image, future outlook, and vocational impact.This project was supported by the BADER Consortium, a Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP) cooperative agreement (W81XWH-11-2-0222) and by a DoD CDMRP award (W81XWH-17-1-0335). This material is the result of work supported with resources and the use of facilities at the James A. Haley Veterans’ Hospital, the Naval Medical Center San Diego, the Center for the Intrepid at San Antonio Military Medical Center, and the Walter Reed National Military Medical Center. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of the institutions involved in the collection, the U.S. Army Medical Department, U.S. Army Medical Research and Development Command, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense, the Department of Veterans Affairs, or the U.S. Government. No author has any conflict of interest with the content of this paper
Erratum: Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum
No full textThe authors note that author Yves Van de Peer was incorrectly listed at affiliation aPlant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University; and that this author’s affiliation at dBioinformatics Institute Ghent, Ghent University was incorrectly omitted. The corrected author and affiliation lines appear below. The online version has been corrected
The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems. V. Do Self-consistent Atmospheric Models Represent JWST Spectra? A Showcase with VHS 1256–1257 b
No full textPetrus, Simon et al.-- Full list of authors: Petrus, Simon; Whiteford, Niall; Patapis, Polychronis; Biller, Beth A.; Skemer, Andrew; Hinkley, Sasha; Suárez, Genaro; Palma-Bifani, Paulina; Morley, Caroline V.; Tremblin, Pascal; Charnay, Benjamin; Vos, Johanna M.; Wang, Jason J.; Stone, Jordan M.; Bonnefoy, Mickaël; Chauvin, Gaël; Miles, Brittany E.; Carter, Aarynn L.; Lueber, Anna; Helling, Christiane; Sutlieff, Ben J.; Janson, Markus; Gonzales, Eileen C.; Hoch, Kielan K. W.; Absil, Olivier; Balmer, William O.; Boccaletti, Anthony; Bonavita, Mariangela; Booth, Mark; Bowler, Brendan P.; Briesemeister, Zackery W.; Bryan, Marta L.; Calissendorff, Per; Cantalloube, Faustine; Chen, Christine H.; Choquet, Elodie; Christiaens, Valentin; Cugno, Gabriele; Currie, Thayne; Danielski, Camilla; De Furio, Matthew; Dupuy, Trent J.; Factor, Samuel M.; Faherty, Jacqueline K.; Fitzgerald, Michael P.; Fortney, Jonathan J.; Franson, Kyle; Girard, Julien H.; Grady, Carol A.; Henning, Thomas; Hines, Dean C.; Hood, Callie E.; Howe, Alex R.; Kalas, Paul; Kammerer, Jens; Kennedy, Grant M.; Kenworthy, Matthew A.; Kervella, Pierre; Kim, Minjae; Kitzmann, Daniel; Kraus, Adam L.; Kuzuhara, Masayuki; Lagage, Pierre-Olivier; Lagrange, Anne-Marie; Lawson, Kellen; Lazzoni, Cecilia; Leisenring, Jarron M.; Lew, Ben W. P.; Liu, Michael C.; Liu, Pengyu; Llop-Sayson, Jorge; Lloyd, James P.; Macintosh, Bruce; Mâlin, Mathilde; Manjavacas, Elena; Marino, Sebastián; Marley, Mark S.; Marois, Christian; Martinez, Raquel A.; Matthews, Elisabeth C.; Matthews, Brenda C.; Mawet, Dimitri; Mazoyer, Johan; McElwain, Michael W.; Metchev, Stanimir; Meyer, Michael R.; Millar-Blanchaer, Maxwell A.; Mollière, Paul; Moran, Sarah E.; Mukherjee, Sagnick; Pantin, Eric; Perrin, Marshall D.; Pueyo, Laurent; Quanz, Sascha P.; Quirrenbach, Andreas; Ray, Shrishmoy; Rebollido, Isabel; Adams Redai, Jea; Ren, Bin B.; Rickman, Emily; Sallum, Steph; Samland, Matthias; Sargent, Benjamin; Schlieder, Joshua E.; Stapelfeldt, Karl R.; Tamura, Motohide; Tan, Xianyu; Theissen, Christopher A.; Uyama, Taichi; Vasist, Malavika; Vigan, Arthur; Wagner, Kevin; Ward-Duong, Kimberly; Wolff, Schuyler G.; Worthen, Kadin; Wyatt, Mark C.; Ygouf, Marie; Zurlo, Alice; Zhang, Xi; Zhang, Keming; Zhang, Zhoujian; Zhou, YifanThe unprecedented medium-resolution (R λ ∼ 1500–3500) near- and mid-infrared (1–18 μm) spectrum provided by JWST for the young (140 ± 20 Myr) low-mass (12–20 M Jup) L–T transition (L7) companion VHS 1256 b gives access to a catalog of molecular absorptions. In this study, we present a comprehensive analysis of this data set utilizing a forward-modeling approach applying our Bayesian framework, ForMoSA. We explore five distinct atmospheric models to assess their performance in estimating key atmospheric parameters: T eff, log(g), [M/H], C/O, γ, f sed, and R. Our findings reveal that each parameter's estimate is significantly influenced by factors such as the wavelength range considered and the model chosen for the fit. This is attributed to systematic errors in the models and their challenges in accurately replicating the complex atmospheric structure of VHS 1256 b, notably the complexity of its clouds and dust distribution. To propagate the impact of these systematic uncertainties on our atmospheric property estimates, we introduce innovative fitting methodologies based on independent fits performed on different spectral windows. We finally derived a T eff consistent with the spectral type of the target, considering its young age, which is confirmed by our estimate of log(g). Despite the exceptional data quality, attaining robust estimates for chemical abundances [M/H] and C/O, often employed as indicators of formation history, remains challenging. Nevertheless, the pioneering case of JWST's data for VHS 1256 b has paved the way for future acquisitions of substellar spectra that will be systematically analyzed to directly compare the properties of these objects and correct the systematics in the models. © 2024. The Author(s).This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. We are truly grateful for the countless hours that thousands of people have devoted to the design, construction, and commissioning of JWST. This project was supported by a grant from STScI (JWST-ERS-01386) under NASA contract NAS5-03127. This work benefited from the 2022 Exoplanet Summer Program in the Other Worlds Laboratory (OWL) at the University of California, Santa Cruz, a program funded by the Heising-Simons Foundation. S.P. acknowledges the support of ANID, –Millennium Science Initiative Program–Center Code NCN19_171. This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (COBREX; grant agreement No. 885593) and from the ANR project FRAME (ANR-20-CE31-0012). J.M.V. acknowledges support from a Royal Society—Science Foundation Ireland University Research Fellowship (URF\1\221932). S.M. is supported by a Royal Society University Research Fellowship (URF-R1-221669). M.B. received funding from the European Union's Horizon 2020 research and innovation program (AtLAST; grant agreement No. 951815). R.A.M. is supported by the National Science Foundation MPS-Ascend Postdoctoral Research Fellowship under grant No. 2213312. E.G. acknowledges support from the Heising-Simons Foundation for this research. I.R. is supported by grant FJC2021-047860-I and PID2021-127289NB-I00 financed by MCIN/AEI /10.13039/501100011033 and the European Union NextGenerationEU/PRTR. A.Z. and S.P. acknowledge support from ANID—Millennium Science Initiative Program—Center Code NCN2021_080. All of the data presented in this article were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute. The specific observations analyzed can be accessed via 10.17909/ceq5-9g20.Peer reviewe
What Makes a Good Health ‘App’? Identifying the Strengths and Limitations of Existing Mobile Application Evaluation Tools
No full textesearch using mHealth apps has the potential to positively impact health care management and outcomes. However, choosing an appropriate mHealth app may be challenging for the health researcher. The author team used existing evaluation tools, checklists, and guidelines to assess selected mHealth apps to identify strengths, challenges, and potential gaps within existing evaluation tools. They identified specific evaluation tool components, questions, and items most effective in examining app content, usability, and features, including literacy demand and cultural appropriateness; technical information; practical aspects of app functionality; and evolving capabilities of mobile medical apps. Challenges included the subjective nature of the results, time required to complete the evaluation, lack of emphasis on evidence-based content, and inadequate tool flexibility. Health researchers considering the integration of mobile apps into research will benefit from evaluation tools that assess both evidence-based content and the ability of the mobile app to securely integrate with other digital technologies involved in patient care. Next steps will include the involvement of health care providers and professionals, including nurses a wide range of expertise, to develop an mHealth evaluation tool that focuses on identifying quality, evidence-based mobile apps into patient outcomes research
