70 research outputs found
Correction: Wu et al. Effect of Highland Barley on Rheological Properties, Textural Properties and Starch Digestibility of Chinese Steamed Bread. Foods 2022, 11, 1091
No full textIn the original publication [...
Analysis of Crustal Movement and Deformation in Mainland China Based on CMONOC Baseline Time Series
No full textIn this paper, we propose a method for the analysis of tectonic movement and crustal deformation by using GNSS baseline length change rates or baseline linear strain rates. The method is applied to daily coordinate solutions of continuous GNSS stations of the Crustal Movement Observation Network of China (CMONOC). The results show that: (a) The baseline linear strain rates are uneven in space, which is prominent in the Tianshan, Sichuan-Yunnan, Qinghai-Tibet Plateau, and Yanjing areas, with a maximum value of 1 × 10−7 a−1, and about two orders smaller in the South China block, the Northeast block, and the inner area of the Tarim basin, where the average baseline linear strain rates are 1.471 × 10−9 a−1, 2.242 × 10−9 a−1, and 3.056 × 10−9 a−1, respectively; (b) Active crustal deformation and strong earthquakes in the Xinjiang area are mainly located in the north and south sides of the Tianshan block; the compression deformations both inside the Tarim block and in the southern Tianshan fault zone are all increasing from east to west, and the Tarim block is not a completely “rigid block”, with the shrinkage rate in the west part at about 1~2 mm/a; (c) The principal directions of crustal deformation in the Xinjiang, Tibet, and Sichuan-Yunnan regions are generally in the north—south compression and east—west extension, indicating that the collision and wedging between the Indian and Eurasian plates are still the main source of tectonic movements in mainland China
The Optimization of MOP Control Strategy for a Range-Extended Electric Vehicle Based on GA
No full textRESEARCH ON MECHANISM OF SHENLING BAIZHU SAN ON DIABETIC OBESITY BASED ON META-ANALYSIS AND NETWORK PHARMACOLOGY
No full textObjective: To evaluate the therapeutic effects of Shenling Baizhu San on diabetic obesity by literature meta-analysis and analyze the mechanism of Shenling Baizhu San on diabetic obesity by combining network pharmacology and animal experiment methods.
Methods: 1. Relevant literatures at home and abroad were included. The BMI, glycosylated hemoglobin (HbA1c), 2h postprandial blood glucose (2hPG), Fasting Blood Glucose (FBG), Homa-IR, waist-to-hip ratio were used as outcome indicators to evaluate the effects of Shenling Baizhu San on diabetic obesity. 2. The related genes of diabetes obesity in GEO chip were downloaded, and the targets of Shenling Baizhu San were downloaded in TCMSP, TCMID and BATMAN-TCM. Protein interaction analysis was carried out on the intersection targets of the two, and then the core target protein was screened out based on topological analysis. 3. The model of diabetic obese mice was established, and the mice were treated with Shenling Baizhu San after grouping. After two weeks, the body mass, blood sugar and Lee\u27s index of mice in each group were measured. The volume changes of adipocytes in each group were analyzed by Hematoxylin-Eosin method, and the concentrations of cholesterol, triglyceride and core target protein in mice serum were measured.
Results: 1. A total of 9 literatures were included, the data were complete, no publication bias was found, and the evaluation was low risk. After administration of Shenling Baizhu San, the BMI, HbA1c, 2hPG, FBG, Homa-IR and waist-hip ratio of the patients were significantly improved. 2. There were 337 genes related to diabetes obesity, 2067 targets of Shenling Baizhu San and 59 intersecting targets. There were 7 signal pathways related to the effect of Shenling Baizhu San on diabetes obesity, including Biosynthesis of unsaved fatty acids, Fatty acid metabolism and so on. 3. The results of animal experiment showed that the blood glucose of mice treated with Shenling Baizhu San was not significantly changed, the body weight and Lee\u27s index showed a significant downward trend, the fat cells were significantly reduced, and the contents of cholesterol and triglyceride, the concentration of APO-E, IGF-1 and PAI-1 protein showed a downward trend.
Conclusion: Based on the results of meta-analysis and animal experiments, Shenling Baizhu San had obvious therapeutic effect on diabetic obesity, and its mechanism may be related to influencing the synthesis of unsaturated fatty acids and fatty acids, reducing the transformation of glucose and fat, correcting the imbalance of energy metabolism in the body, and promoting the decomposition of adipose tissue by up-regulating autophagy
The Applications of Machine Vision in Raw Material and Production of Wood Products
No full textMachine vision has been developed nearly for 70 years and been widely applied in electronics, automotive manufacturing, food processing, etc. With deepening study of its theory and technology in forestry industry, the industry of wood products is moving steadily toward the goal of automated identification and production to improve the manufacturing intelligence of enterprises. In this study, theoretical and algorithmic research on image acquisition, feature extraction, recognition, and classification involved in machine vision-based wood recognition technology were analyzed on the basis of its global development. The applications of machine vision in the wood materials, such as the identification of tree species, wood inspection and classification, defects detection of wood product, surface analysis of wood color, and quality control of furnishing products were thoroughly analyzed. The development trend of machine vision in the production and management of wood materials was considered in the current development of wood and furnishing enterprises. These results lay a solid foundation for wood science research, and intelligent manufacture of wooden furniture, and efficient development of greener and cleaner production of the furniture industry, which could improve the environmental effect of the wood products and furniture and make a great contribution for the carbon goal of “30-60” in China
Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
No full textAbstract Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about the changes of synaptic KAR in the cortical area of Fmr1 KO mice. In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons in the insular cortex of Fmr1 KO mice. We found that KARs mediated currents were reduced in Fmr1 KO mice. KARs were mainly located in the synaptosomal fraction of the insular cortex. The abundance of KAR subunit GluK1 and GluK2/3 in the synaptosome was reduced in Fmr1 KO mice, whereas the total expressions of these KARs subunits were not changed. Finally, lack of FMRP impairs subsequent internalization of surface GluK2 after KAR activation, while having no effect on the surface GluK2 expression. Our studies provide evidence indicating that loss of FMRP leads to the abnormal function and localization of KARs. This finding implies a new molecular mechanism for Fragile X syndrome
Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin‐induced cardio toxicity via suppressing oxidative stress and apoptosis
No full textComprehensive Analysis of GASA Family Members in the Peanut Genome: Identification, Characterization, and Their Expressions in Response to Pod Development
No full textThe gibberellic acid-stimulated Arabidopsis (GASA) gene family is essential for plant growth and development, hormone level control, and phytohormone signal transmission. Different plants have been shown to contain numerous GASA homologs. However, there is no knowledge about these proteins in peanuts. In the current study, we performed a thorough bioinformatics and expression analysis and found 20, 22, and 40 GASA genes by genome-wide analyses of A. hypogaea L., A. duranensis, and A. ipaensis, respectively. We analyzed and predicted the physical properties of these genes. Based on the results of our phylogenetic analysis, the evolutionary tree constructed from the 40 AhGASA proteins was divided into seven categories, forming a total of 14 gene pairs. According to our observations, tandem duplication is a significant factor in the expansion of the GASA gene family. AhGASA was unevenly distributed on 20 chromosomes, and 17 tandem duplicated genes were identified. A co-lineage analysis with the A/B subgenome identified 69 linear/parallel homologous gene pairs. A cis-element analysis revealed that the AhGASA protein is crucial for hormone responsiveness. In materials with different size traits at various stages of peanut pod development, transcriptomics and RT-qPCR analyses revealed that AhGASA genes are expressed at various levels and are tissue-specific. This finding suggests that some AhGASA genes may be involved in controlling peanut pod size. This study suggests that GASA genes are crucial for controlling the development of peanut pods and provides the first systematic identification and analysis of GASA genes in peanut. These findings will help future research into the function of the GASA gene in the cultivated peanut
Analysis of epidemiological characteristics of foodborne disease events in Nanping City from 1998 to 2017
No full textObjective The epidemiological characteristics and patterns of foodborne disease events in Nanping City were analyzed to provide a basis for formulating prevention and control strategies of foodborne disease. Methods Foodborne disease incidents reported from all over Nanping City during 1998 and 2017 were collected, and a retrospective descriptive analysis was conducted. Results A total of 184 foodborne disease incidents were reported in Nanping, with 2 871 cases and 40 deaths, with an annual average incidence of 5.12/100 000 and a case fatality rate of 1.39%. The peak season for foodborne illness was the third quarter, with the highest number of incidents and deaths in August. The number of incidents and patients with the largest number were pathogenic microbial events, accounting for 43.48% (80/184) and 64.86% (1 862/2 871) respectively. Toxic plant accounted for 35.87% (66/184) and 10.80% (310/2 871). The most common pathogenic factor was the accidental eating of poisonous mushrooms, accounting for 29.89% (55/184). Vibrio parahaemolyticus was the second factor, accounting for 12.50% (23/184). The most fatal cases were from mushroom, accounting for 87.50% (35/40). Family were the most occurred site, accounted for 39.13% (72/184), and 66.67% (48/72) were caused by toxic plants. Hotels and restaurants accounted for 22.28% (41/184) and 80.49% (33/41) were pathogenic microorganisms. Conclusion The control strategy of foodborne disease events in Nanping should focus on reducing wild mushroom poisoning and changing bad eating habits, carrying out a wide range of food safety education in vulnerable seasons, months and regions, establishing an effective early warning, monitoring and government supervision mechanism, and reducing the occurrence of foodborne disease
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