233 research outputs found
Kang zhan: du mu xin ju xuan.
No full text在烽火中 / 沈西苓 -- 重逢 / 丁玲 -- 爭取最後勝利 / 塞克 -- 游擊隊的開始 / 張克 -- 我們打沖鋒 / 尤兢 -- 漢奸末路 / 姚時曉 -- 榮譽大隊 / 趙明, 呂復 -- 夜之歌 / 凌鶴 -- 我們放開恩怨 / 石靈 -- 舞女淚 / 集體創作.[沈西苓 ... [et al.]著] ; 戰時劇社編.[Shen Xiling ... [et al.] zhu] ; Zhan shi ju she bian.Zai feng huo zhong / Shen Xiling -- Chong feng / Ding Ling -- Zheng qu zui hou sheng li / Sai Ke -- You ji dui de kai shi / Zhang Ke -- Wo men da chong feng / You Jing -- Han jian mo lu / Yao Shixiao -- Rong yu da dui / Zhao Ming, Lü Fu -- Yan zhi ge / Ling He -- Mo men fang kai en yuan / Shi Ling -- Wu nü lei / Ji ti chuang zuo
Notch Signaling: Mechanistic And Functional Studies In Intestinal Stem Cells And Colorectal Cancer Cells
No full text: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focus within the scientific community, providing mechanistic insight into biological process and offering translational clinical potential. In this thesis we address the contribution of NOTCH signaling in maintaining the stem cell niche by modulating the mode of stem cell division and receptor-ligand interactions for cell-cell communication. Furthermore, we examine NOTCHmediated spatiotemporal recovery of the intestinal stem cell (ISC) niche following single cell ablation. Finally, we demonstrate that elevated NOTCH signaling exists under conditions of physiological stress and in colon cancer initiating cells (CCICs), promoting tumorigenic potential of the intestinal epithelium. Overall, our research highlights the underlying complexities of NOTCH signaling as an essential pathway to maintain intestinal homeostasis and may inspire development of novel CRC therapeutic strategies. Research efforts and findings during my graduate study have been consolidated into the following peer-reviewed publications, of which the four first co-author manuscripts are described in detail in this dissertation. 1. Srinivasan, Tara; Walters, Jewell; Bu, Pengcheng; Than, Elaine B.; Tung, Kuei-Ling; Chen, Kai-Yuan; Panarelli, Nicole; Milsom, Jeff; Augenlicht, Leonard; Lipkin, Steven M; Shen, Xiling. "NOTCH Signaling Regulates Asymmetric Division of Fast- and Slow-Cycling Colon Cancer Initiating Cells." Cancer Research, 2016. (in press) 2. Srinivasan, Tara; Than, Elaine B.; Bu, Pengcheng; Tung, Kuei-Ling; Chen, Kai-Yuan; Augenlicht, Leonard; Lipkin, Steven M.; Shen, Xiling. "NOTCH Signaling Regulates Fast- and Slow-Cycling Intestinal Stem Cells." Scientific Reports, 2016. (in press) 3. Chen, Kai-Yuan*; Srinivasan, Tara*; Choi, Jiahn*; Bu, Pengcheng; Tung, Kuei-Ling; Nishimura, Nozomi; Shen, Xiling. "Dynamic regulation of intestinal stem cell niche recovery in real-time." Cell Systems, 2015. (in review) 4. Murthy, Preetish KL*; Srinivasan, Tara*; Bochter, Skye; Bu, Pengcheng; Cole, Susan; Shen, Xiling. "FRINGE-dependent modification of NOTCH Ligands in Intestinal Stem Cells." 2016. (in preparation) 5. Rothschild, Daniel; Srinivasan, Tara; Aponte-Santiago, Linette; Shen, Xiling; Irving, Allen. "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids." JoVE, 2015. (in press) 6. Bu, Pengcheng*; Wang, Lihua*; Chen, Kai-Yuan; Srinivasan, Tara; Lakshminarasimha, Preetish; Tung, Kuei-Ling; Varanko, Anastasia; Ai, Yiwei; Lipkin, Steven; Shen, Xiling. "miR34a and Numb synergize for asymmetric cell fate determination." Cell Stem Cell, 2016 Feb 4;18(2):189-202. 7. Crespo, Miguel; Tsai, Su-Yi; Srinivasan, Tara; Pipalia, Nina; Maxfield, Nina; Lipkin, Steven M; Evans, Todd; Chen, Shuibing. "Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing." Nature Medicine, 2015. (in review) 8. Wang, Lihua*; Bu, Pengcheng*; Ai, Yiwel; Srinivasan, Tara; Lipkin, Steven M; Shen, Xiling. "A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division." eLife, 2016. (in press
sj-docx-2-jva-10.1177_11297298211052528 – Supplemental material for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial
No full textSupplemental material, sj-docx-2-jva-10.1177_11297298211052528 for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial by Chunli Huang, Zhenming Wu, Weihua Huang, Xinghong Zhang, Xiling Lin, Jielin Luo, Lihua Li and Jia Li in The Journal of Vascular Access</p
sj-docx-1-jva-10.1177_11297298211052528 – Supplemental material for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial
No full textSupplemental material, sj-docx-1-jva-10.1177_11297298211052528 for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial by Chunli Huang, Zhenming Wu, Weihua Huang, Xinghong Zhang, Xiling Lin, Jielin Luo, Lihua Li and Jia Li in The Journal of Vascular Access</p
现代日中书道团体的交流 : 以“鸣鹤流”天溪会与西泠印社为例
No full textTenkeikai Society and Xiling Seal Engraver’s Society are two calligraphy groups active in modern Japan and China. The two groups were linked by the friendship between the two calligraphers Kusakabe Meikaku and Wu Changshuo. This paper takes early contacts between Kusakabe and Wu as the starting point, traces their early contacts and the interchanges between Tenkeikai Society and Xiling Seal Engraver’s Society under their respective, and further explores the cultural exchange Japanese and Chinese calligraphy groups.陶徳民教授古稀記念号departmental bulletin pape
TERMS OF TRADE BETWEEN AGRICULTURE AND INDUSTRY -- THIRTY YEARS EXPERIENCE IN CHINA
No full textThe relationship between agriculture and industry is very important in any economic development. The whole process of development can be understood in the context of the relationship between agriculture and industry and its evolution. This is because first, agriculture and industry are usually the biggest and primary material production sectors in the economy, they provide physical goods for a society's survival and the foundation for any further development. Second, it becomes more and more clear that one sector cannot develop properly without the other.
The purpose of this paper is to explore the agriculture industry relationship from the point of view of the intersectoral terms of trade, which is considered as the most important factor in agriculture industry relationship because the connection between the two sectors is mainly through product exchanges
TERMS OF TRADE BETWEEN AGRICULTURE AND INDUSTRY -- THIRTY YEARS EXPERIENCE IN CHINA
No full textThe relationship between agriculture and industry is very important in any economic development. The whole process of development can be understood in the context of the relationship between agriculture and industry and its evolution. This is because first, agriculture and industry are usually the biggest and primary material production sectors in the economy, they provide physical goods for a society's survival and the foundation for any further development. Second, it becomes more and more clear that one sector cannot develop properly without the other. The purpose of this paper is to explore the agriculture industry relationship from the point of view of the intersectoral terms of trade, which is considered as the most important factor in agriculture industry relationship because the connection between the two sectors is mainly through product exchanges.Industrial Organization, International Relations/Trade,
Simulation of a mixed wave and definition of nonlinearity parameter with diffraction correction
No full textThe acoustic nonlinearity parameter has been frequently measured for early detection of micro damage in various materials. The technique typically employs a toneburst signal of single frequency and measures the second harmonic generation during its propagation in through-transmission mode. In this work, we propose a two wave mixing technique and the use of difference frequency components in determining the nonlinearity parameter. One important advantage of this technique is to use difference frequency components apart from higher harmonics including the second harmonic, therefore effects of source nonlinearity can be minimized and low attenuating nonlinear signal can be acquired.
Beam fields radiated from various configurations of radiating transducers are simulated. The fundamental and difference frequency waves are calculated using the multi-Gaussian beam model based on the quasilinear solution for the Westervelt equation. Explicit expressions for diffraction and attenuation corrections are derived, and the nonlinearity parameter is newly defined with these corrections included.</p
Relationship between agricultural growth and farm imports in LDCs: a Sims' causality test based on 35 countries
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