10,370 research outputs found
Evaluation of a point-of care analyzer for determination of basal serum total thyroxine concentration in cats.
No full textBeyond East and West: What ‘Ladder’ Did John Wu Use Towards This Goal? (Part One)
No full text„Poza Wschodem i Zachodem” – jakiej „drabiny” użył John Wu do osiągnięcia tego celu?
John Wu Jingxiong (1899-1986) był dyplomatą, uczonym i autorytetem w dziedzinie prawa międzynarodowego. Był także wybitnym chińskim katolikiem. Jego duchowa autobiografia Beyond East and West (1951) przypomina Wyznania św. Augustyna poprzez poruszający opis nawrócenia Johna Wu na katolicyzm w 1937 r. i jego wczesne lata jako katolika. Sam tytuł autobiografii Wu wskazuje na jego duchowy ideał, który pozwala ludziom wykraczać poza kulturowe osobliwości (czy to zachodnie, chińskie czy inne). John Wu znalazł mądrość w wielkich chińskich tradycjach, tj. w konfucjanizmie, daoizmie i buddyzmie, wskazując na ich uniwersalne prawdy, które ostatecznie pochodzą od Chrystusa i w nim się wypełniają. Autor tego artykułu szukał uniwersalnych cech Johna Wu, które wykraczają poza jakąkolwiek kulturę i które metaforycznie nazwał „drabiną”. Znalazł potrójną drabinę, tj. wiarę chrześcijańską, przyjaźń wraz ludzką i boską miłością i prawo naturalne.John Wu Jingxiong (1899-1986) was a diplomat, scholar, and authority on international law. He was also a prominent Chinese Catholic convert. His spiritual autobiography Beyond East and West (1951) reminds us of the Confessiones of St. Augustine for its moving description of John Wu’s conversion to Catholicism in 1937 and his early years as a Catholic. The very title of Wu’s autobiography points to his spiritual ideal which let humanity go beyond cultural particularities (be they Western, Chinese or other). John Wu found wisdom in China’s great traditions, i.e. Confucianism, Daoism and Buddhism, pointing to their universal truths that come ultimately from, and are fulfilled in, Christ. The author of this contribution has searched for John Wu’s universal traits which go beyond any culture and which he called, metaphorically, a “ladder”. He has found a threefold ladder, i.e. that of Christian faith, that of human friendship and human and divine love, and that of natural law
„Poza Wschodem i Zachodem” – jakiej „drabiny” użył John Wu do osiągnięcia tego celu?
No full textJohn Wu Jingxiong (1899-1986) was a diplomat, scholar, and authority on international law. He was also a prominent Chinese Catholic convert. His spiritual autobiography Beyond East and West (1951) reminds us of the Confessiones of St. Augustine for its moving description of John Wu’s conversion to Catholicism in 1937 and his early years as a Catholic. The very title of Wu’s autobiography points to his spiritual ideal which let humanity go beyond cultural particularities (be they Western, Chinese, or other). John Wu found wisdom in China’s great traditions, i.e., Confucianism, Daoism and Buddhism, pointing to their universal truths that come ultimately from, and are fulfilled in, Christ. The author of this contribution has searched for John Wu’s universal traits which go beyond any culture and calls them, metaphorically, a “ladder”. He has found a threefold ladder, i.e. that of the Christian faith, of human friendship and human and divine love, and that of natural law.John Wu Jingxiong (1899-1986) był dyplomatą, uczonym i autorytetem w dziedzinie prawa międzynarodowego. Był także wybitnym chińskim katolikiem. Jego duchowa autobiografia Beyond East and West (1951) przypomina Wyznania św. Augustyna poprzez poruszający opis nawrócenia Johna Wu na katolicyzm w 1937 r. i jego wczesne lata jako katolika. Sam tytuł autobiografii Wu wskazuje na jego duchowy ideał, który pozwala ludziom wykraczać poza kulturowe osobliwości (czy to zachodnie, chińskie czy inne). John Wu znalazł mądrość w wielkich chińskich tradycjach, tj. w konfucjanizmie, daoizmie i buddyzmie, wskazując na ich uniwersalne prawdy, które ostatecznie pochodzą od Chrystusa i w nim się wypełniają. Autor tego artykułu szukał uniwersalnych cech Johna Wu, które wykraczają poza jakąkolwiek kulturę i które metaforycznie nazwał „drabiną”. Znalazł potrójną drabinę, tj. wiarę chrześcijańską, przyjaźń wraz ludzką i boską miłością i prawo naturalne
Effects of diesel exhaust particles on left ventricular function in isoproterenol induced myocardial injury and healthy rats
No full text
Will biological agents supplant systemic glucocorticoids as the first-line treatment for thyroid-associated ophthalmopathy?
No full textIn this article, the two authors present their opposing points of view concerning the likelihood that glucocorticoids will be replaced by newly developed biological agents in the treatment of active, moderate-to-severe thyroid-associated ophthalmopathy (TAO). TAO is a vexing, disfiguring and potentially blinding autoimmune manifestation of thyroid autoimmunity. One author expresses the opinion that steroids are nonspecific, frequently fail to improve the disease and can cause sometimes serious side effects. He suggests that glucocorticoids should be replaced as soon as possible by more specific and safer drugs, once they become available. The most promising of these are biological agents. The other author argues that glucocorticoids are proven effective and are unlikely to be replaced by biologicals. He reasons that while they may not uniformly result in optimal benefit, they have been proven effective in many reports. He remains open minded about alternative therapies such as biologicals but remains skeptical that they will replace steroids as the first-line therapy for active, moderate-to-severe TAO without head-to-head comparative clinical trials demonstrating superiority. Despite these very different points of view, both authors are optimistic about the availability of improved medical therapies for TAO, either as single agents or in combination. Further, both agree that better treatment options are needed to improve the care of our patients with active moderate-to-severe TAO
Wheel/rail non-linear interactions with coupling between vertical and lateral directions
No full textSummary A theoretical model is developed to explore the high frequency wheel/rail interaction with coupling between the vertical and lateral directions. This coupling is introduced through the track dynamics due to the offset of the wheel/rail contact point from the rail centre line. Equivalent models of the railway track in the time domain are developed according to the rail vibration receptances in the frequency domain. The wheel is represented by a mass in each direction with no vertical-lateral coupling. The vertical wheel/rail interaction is generated through a non-linear Hertzian contact stiffness, allowing for the possibility of loss of contact between the wheel and rail. The lateral interaction is represented by a contact spring and a creep force damper in series and their values depend on the vertical contact force. The vibration source is the roughness on the wheel and rail contact surfaces which forms a relative displacement excitation in the vertical direction. Using the combined interaction model with this relative displacement excitation, the wheel/rail interactions with coupling between the vertical and lateral vibrations are simulated. It is found that the lateral interaction force caused by the offset is usually less than thirty percent of the vertical dynamic force. The lateral vibration of the rail is significantly reduced due to the presence of the lateral coupling, whereas the vertical interaction is almost unaffected by the lateral force
An investigation into rail corrugation due to micro-slip under multiple wheel/rail interactions
Full text linkThe formation of short pitch corrugation on the railhead is studied by using an approach combining wheel/track dynamics, contact mechanics and wear. Multiple wheel/rail interactions are taken into account in the wheel/track dynamics. A quasi-static method based on a two-dimensional contact model is used to solve the unsteady rolling contact problem where the normal contact force and the surface curvature vary. The longitudinal slip due to traction is considered. Corrugation growth rate is calculated at different wavelengths and at two train speeds using parameters from a British Class 87 electric locomotive and typical track. It has been found that the corrugation growth rate becomes largest when the phase of the normal dynamic contact force is such that its peak occurs about 135° after the corresponding trough in the roughness. The wear is found to be heavier at shorter wavelength and proportional to the amplitude of the dynamic contact force. In addition corrugation is shown to develop more quickly using stiffer pads than softer pads, whereas growth occurs at several frequencies for softer pads
The effects of track non-linearity on wheel/rail impact
No full textWheel/track impact due to rail joints or wheel flats has been studied over many years. The railway track is usually assumed to be linear in order to simplify the track model, although the rail pad and ballast are actually non-linear. This may cause incorrect results to some extent in some circumstances, as the pad and ballast stiffness varies with load. In this paper wheel/track impact is studied using a non-linear track model. The rail is represented by a finite element (FE) model and is supported by a non-linear track foundation. Wheel/track impacts are simulated at different train speeds and three types of rail pad, soft, medium and stiff, are used in the simulations. It is shown that the impact forces rise dramatically when the stiff rail pads are used. On the other hand, using soft pads can reduce impact forces significantly. Compared with the results from the linear track model, both the impact force and the track vibration level are shown to be noticeably higher from the nonlinear track than those from the linear track. It is therefore concluded that linear track models are not appropriate for wheel/track impact because the track foundation stiffness varies dramatically under the impact force
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