8,021 research outputs found
The genetic differences with whole genome linkage disequilibrium mapping between responder and non-responder in interferon-alpha and ribavirin combined therapy for chronic hepatitis C patients.
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DITERPENOID ALKALOIDS FROM ACONITUM-VILMORRIANUM
No full textA new diterpenoid alkaloid, vilmorrianone (1), has been isolated from Aconitum vilmorrianum Kom. The structure was elucidated by spectral methods and confirmed by X-ray diffraction analysis. Also four known diterpenoid alkaloids have been isolated and identified
Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits.
No full textAuthor Attributions in Medieval Text Collections: An Exploration
Full text linkThis article examines the role and function of author attributions in multi-text manuscripts containing Dutch, English, French or German short verse narratives. The findings represent one strand of the investigations undertaken by the cross-European project ‘The Dynamics of the Medieval Manuscript’, which analysed the dissemination of short verse narratives and the principles of organisation underlying the compilation of text collections. Whilst short verse narratives are more commonly disseminated anonymously, there are manuscripts in which authorship is repeatedly attributed to a text or corpus. Through six case studies, this article explores medieval concepts of authorship and how they relate to constructions of authority, whether regarding an empirical figure or a literary construction. In addition, it looks at how authorship plays a role in manuscript compilation, and at the effects of attributions (by author and/or compiler) on reception. The case studies include manuscripts from the thirteenth to fifteenth centuries, produced in a range of social and cultural contexts, and featuring some of the most important European authors of short verse narratives: Rutebeuf, Baudouin de Condé, Der Striker, Konrad von Würzberg, Willem of Hildegaersberch, and Geoffrey Chaucer. The preliminary findings contribute to our understanding of author attributions in text collections from across northern Europe and point towards future lines of enquiry into the role of authorship in medieval textual dissemination
Batch Bayesian Learning of Large-Scale LS-SVMs Based on Low-rank Tensor Networks
No full textLeast Squares Support Vector Machines (LS-SVMs) are state-of-the-art learning algorithms that have been widely used for pattern recognition. The solution for an LS-SVM is found by solving a system of linear equations, which involves the computational complexity of O(N^3). When datasets get larger, solving LS-SVM problems with standard methods becomes burdensome or even unfeasible. The Tensor Train (TT) decomposition provides an approach to representing data in highly compressed formats without loss of accuracy. By converting vectors and matrices in the TT format, the storage and computational requirements can be greatly reduced. In this thesis, we develop a Bayesian learning method in the TT format to solve large-scale LS-SVM problems, which involves the computation of a matrix inverse. This method allows us to include the information we know about the model parameters in the prior distribution. As a result, we are able to obtain a probability distribution of the parameters, which enables us to construct confidence levels of the predictions. In the numerical experiment, we show that the developed method performs competitively with the current methods.Mechanical Engineering | Systems and Contro
Additive Manufacturing: Polymers Applicable for Laser Sintering (LS)
No full textAbstractAdditive Manufacturing (AM) is close to become a production technique changing the way of part fabrication in future. Enhanced complexity and personalized features are aimed. The expectations in AM for the future are enormous and betimes it is considered as kind of the next industrial revolution. Laser Sintering (LS) of polymer powders is one component of the AM production techniques. However materials successfully applicable to Laser Sintering (LS) are very limited today. The presentation picks up this topic and gives a short introduction on the material available today. Important factors of polymer powders, their significance for effective LS processing and analytical approaches to access those values are presented in the main part. Concurrently the exceptional position of polyamide 12 powders is this connection is outlined
Accurate Wide Angle SAR Imaging Based on LS-CS-Residual
No full textWide angle synthetic aperture radar (WASAR) receives data from a large angle, which causes the problem of aspect dependent scattering. L 1 regularization is a common compressed sensing (CS) model. The L 1 regularization based WASAR imaging method divides the whole aperture into subapertures and reconstructs the subaperture images individually. However, the aspect dependent scattering recovery of it is not accurate. The subaperture images of WASAR can be regarded as the SAR video. The support set among the different frames of SAR video are highly overlapped. Least squares on compressed sensing residuals (LS-CS-Residuals) can reconstruct the time sequences of sparse signals which change slowly with time. This is to replace CS on the observation by CS on the least squares (LS) residual computed using the prior estimate of the support. In this paper, we introduce LS-CS-Residual into WASAR imaging. In the iteration of LS-CS-Residual, the azimuth-range decoupled operators are used to avoid the huge memory cost. Real data processing results show that LS-CS-Residual can estimate the aspect dependent scatterings of the targets more accurately than CS based methods
Simulation of retrofitted unreinforced concrete masonry unit walls under blast loading
Full text linkThis paper describes an investigation into the effectiveness of using spray-on nano-particle reinforced polymer and aluminium foam as new types of retrofit material to prevent the breaching and collapse of unreinforced concrete masonry walls subjected to blast over a whole range of dynamic and impulsive regimes. Material models from the LS-DYNA material library were used to model the behaviors of each of the materials and its interface for retrofitted and unretrofitted masonry walls. Available test data were used to validate the numerical models. Using the validated LS-DYNA numerical models, the pressure-impulse diagrams for retrofitted concrete masonry walls were constructed. The efficiency of using these retrofits to strengthen the unreinforced concrete masonry unit (CMU) walls under various pressures and impulses was investigated using pressure-impulse diagrams. Comparisons were made to find the most efficient retrofits for masonry walls against blasts.Sanam Aghdamy, Chengqing Wu and Michael Griffit
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