234 research outputs found
Abstract 3305: Autophagic induction through upregulation of sestrin-2 transcription and mRNA stability mediates the anticancer effect of new compound ChlA-F
No full textAbstract
ChlA-F is a novel conformation-derivative of Cheliensisin A (Chel A), which is a new styryl-lactone isolated from Chinese Herb Goniothalamus cheliensis Huand shows potent antitumor potential effect both in vitro and in vivo. However, the anticancer activity and its potential mechanisms underlying ChlA-F action have never been explored. In present study, we evaluated the potency of ChlA-F on anchorage-independent growth and its association with autophagic responses in human high grade invasive bladder cancer cells. We found that ChlA-F significantly inhibited anchorage-independent growth of human bladder cancer cells by induction of autophagy in a sestrin2(SESN2)-dependent Fashion. Our results revealed that ChlA-F treatment specifically induced SESN2 expression via increasing its both gene transcription and mRNA stability. On the one hand, ChlA-F treatment markedly attenuated Dicer protein abundance, and in turn abolished miR-27a maturation and further relieved miR-27a directly binding to SESN2 mRNA 3’UTR, thereby promoting SESN2 mRNA stabilization. On the other hand,ChlA-F treatment promoted Sp1 abundance and consequently mediated SESN2 transcription. Moreover, either knockdown of Sp-1 or ectopic expression of miR-27a could abolish the autophagic response and reversed the inhibition of anchorage-independent growth in human bladder cancer cells. These results demonstrate that anticancer effect of ChlA-F is mediated by its activating autophagic pathway through promoting both SESN2 mRNA transcription and stabilization,which offers novel insights into the anticancer effect of ChlA-F on bladder cancer and provides a therapeutic alternative against human bladder cancer.
Citation Format: Xiaohui Hua, Chuanshu Huang, Xueru Wu, Jingxia Li. Autophagic induction through upregulation of sestrin-2 transcription and mRNA stability mediates the anticancer effect of new compound ChlA-F [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3305. doi:10.1158/1538-7445.AM2017-3305</jats:p
Pimoa yajiangensis Irfan & Wang & Zhao & Zhang 2022, new species
No full textPimoa yajiangensis new species Figures 4A, B, 7C, 8 Type material. Holotype: female, China, Sichuan, Yajiang County, Xiangkezong, 29°59′16″N, 100°55′14″E, elev. 3424 m, 14 June 2018, L.Y. Wang, Z.S. Wu and Y.N. Mu leg. (SWUC-T-PI-04-01). Etymology. The specific name refers to the type locality. Diagnosis. Pimoa yajiangensis n. sp. resembles P. reniformis Xu & Li, 2007 (Xu & Li 2007: 493, figs 42–47) in having similar dorsal and ventral plates, which become narrow posteriorly and having an oval mark on the dorsal plate. However, the new species can be distinguished from all other Pimoa species by a heart-shaped epigynal ventral plate and the copulatory ducts with two turns directed dorso-ventrally before entering the spermathecae (Fig. 4A, B). Description. Female (holotype, Fig. 7C): Total length 10.24. Carapace 4.10 long, 3.09 wide. Abdomen 6.84 long, 5.64 wide. Eye sizes and interdistances: AME 0.22, ALE 0.21, PME 0.21, PLE 0.22; AME–AME 0.16, AME– ALE 0.19, PME–PME 0.18, PME–PLE 0.24. Carapace brownish with black lateral margins; thoracic fovea and radial grooves distinct; sternum brownish. Abdomen black with yellowish transverse chevron bands. Legs brownish with black annulations. Leg measurements: I: 21.16 (6.23, 7.08, 5.42, 2.43); II: 19.07 (5.62, 6.33, 4.87, 2.25); III: 14.14 (4.32, 4.44, 3.62, 1.76); IV: 18.56 (5.67, 6.17, 4.73, 1.99). Epigynum (Fig. 4A, B): heart-shaped; ventral and dorsal plates posteriorly narrow; copulatory openings distinct; Copulatory ducts with two turns and not fused; spermathecae round, touching each other; fertilization ducts oriented laterally. Male. Unknown. Distribution. Known only from the type locality, Sichuan, China (Fig. 8).Published as part of Irfan, Muhammad, Wang, Lu-Yu, Zhao, Jingxia & Zhang, Zhi-Sheng, 2022, Three new species of the spider genus Pimoa Chamberlin & Ivie, 1943 (Araneae, Pimoidae) from Qinghai-Tibet Plateau of China, pp. 318-330 in Zootaxa 5092 (3) on pages 324-325, DOI: 10.11646/zootaxa.5092.3.4, http://zenodo.org/record/588121
Application of the “Hand-as-Foot” teaching method in localizing of myocardial infarction area
No full text中国网络流行语在新加坡的传播与使用情况——以《咬文嚼字》年度十大流行语为例 = The spread and use of China's internet buzzwords in Singapore
No full text互联网与社交媒体的发展形成了一种新颖且特殊的语言形式，即网络语言。网络流行语是网络语言的一种语言形式，可定义为某一段时期在网络上受人们广泛使用以及传播，具有时代性的语言形式。网络流行语在中国是极为普遍的现象，尤其在于年轻群体当中。网络流行语目前的研究着重于中国社会。众多学者对网络流行语进行了研究，如网络流行语的类型与特征、传播与变迁以及使用情况。少数的研究者在中国以外展开网络流行语的调查或将中老年群体包括在调查对象当中。在新加坡，则没有学者针对网络流行语的使用进行实证调查研究。笔者希望填补网络流行语研究的空缺，因此通过问卷调查的方式，并以年龄层与时间段的角度探讨新加坡网络流行语的传播与使用情况、态度与其因素。本研究发现，青年和中老年这两个年龄组的调查对象都对实用性高的网络流行语认知度高，对与中国政策相关的流行语认知度低，对形式简单的流行语理解度高。另外，本研究的结果显示了网络流行语认知度、理解度与使用度之间的可能关系——较低的认知度导致较低的理解度，从而降低使用度。其次，两个年龄组对于早期的网络流行语认知度、理解度与使用度较高，且青年组在这三方面的程度都比中老年组的更高。本研究发现这些现象与网络因素以及与中国媒体或亲友的接触有可能的关系。
最后，两组对网络流行语的态度都较为积极，但青年组比中老年组的表现更加为乐观，支持也更为强烈。笔者希望这项调查研究能够为新加坡网络流行语的各别情况提供价值性的参考，对新加坡语言方面的研究作出贡献。关键词:网络流行语;实证研究;使用情况;新加坡华语 The development of the Internet and social media has created a new and distinct language form, Internet language. Internet buzzwords are a form of Internet language, which can be defined as a language form that is widely used and disseminated on the Internet during a certain period of time. They are extremely common in China, especially among the younger generation. Current research on Internet buzzwords focuses on China’s society, and many scholars have conducted research on the types and characteristics of Internet buzzwords, their dissemination and changes, and their usage. Very few researchers conducted surveys on Internet buzzwords outside of China or included middle-aged/elderly groups in their targeted groups. In Singapore, no scholars have conducted empirical research on the use of Internet buzzwords. The author hopes to fill up current research gaps in this area. Hence in this research, a questionnaire survey was conducted, targeting the young and middle-aged/elderly groups and discussing the spread and use of Internet buzzwords in Singapore and the attributing factors to related trends from the perspectives of age group and time period. This study found that respondents in both age groups have higher degree of cognition towards Internet buzzwords that are practical in terms of use and lower degree of cognition towards buzzwords related to China's policies. Respondents from both age groups also have higher degree of understanding towards buzzwords that come in simpler forms. In addition, the results of this study show a possible relationship between degree of cognition, understanding and usage of Internet buzzwords, that is, lower degree of cognition leads to lower degree of understanding, which in turn leads to lower usage. Moreover, the study also found that both age groups have a higher degree of cognition, understanding and usage of Internet buzzwords from the earlier period, and in these three aspects, the results from the youth group is shown to be higher than that of the middle-aged/elderly group. This study found that these phenomena may be related to network factors and contact with China’s media or Chinese relatives and friends. Also, both groups were found to have positive attitudes towards Internet buzzwords, but the youth group showed stronger optimism and support. The author hopes that this investigation and research can provide valuable references for the individual situations of Singaporean Internet buzzwords and contribute to the study of Singaporean language. Keywords: Internet Buzzwords; Empirical Research; Usage Situation; Singapore MandarinBachelor of Arts in Chines
The elemental pegging effect in locally ordered nanocrystallites of high-entropy oxide enables superior lithium storage
No full textHigh-entropy oxides (HEOs) can be well suited for lithium-ion battery anodes because of their multi-principal synergistic effect and good stability. The appropriate selection and combination of elements play a crucial role in designing conversion-type anode materials with outstanding electrochemical performance. In this study, we have successfully built a single-phase spinel-structured HEO material of (Mn0.23Fe0.23Co0.22Cr0.19Zn0.13)3O4 (HEO-MFCCZ). When the HEO-MFCCZ materials transform into a coexisting state of amorphous and nanocrystalline structures during the cycling process, the inert Zn element can initiate a pegging effect, causing enhanced stability. The transition also introduces many defect sites, effectively reducing the potential barrier for ion transport and accelerating ion transport. The increased electronic and ionic conductivities and pseudocapacitive contribution significantly enhance the rate performance. As a result, a unique and practical approach is provided for developing anode materials for lithium-ion batteries.No Full Tex
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Free trade and cultural diversity in international law /
No full text"This book attempts to reconcile the concept of free trade with a key non-trade social value - cultural diversity - in an era of economic globalisation. It first shows how we can look at culture in many different ways, and explains why we should care about cultural diversity. The book then examines the challenges that policymakers are faced with in formulating cultural measures in the new media environment, and analyses UNESCO's theories and approaches to cultural diversity. This is followed by a comprehensive examination of the treatment of 'culture' in global and regional trade agreements, including the framework of the GATT/WTO system, the WTO's judicial practice involving cultural products, and the treatment of culture under the EC/EU and NAFTA. This identifies the challenges trade norms encounter in dealing with cultural products. The author seeks to formulate a balanced view of the challenge of protecting and promoting cultural diversity while also recognising the important goal of trade liberalisation. To this end Professor Shi proposes a dual method through which the norms found in WTO agreements and in UNESCO cultural instruments may be brought into alignment: the first highlighting the compatibility of cultural policy measures with trade obligations on a domestic level, the second suggesting potential linkages between the WTO rules and the UNESCO Convention from the perspectives of treaty interpretation."--Bloomsbury Publishing
On the Gender Discrimination in English
No full textLanguage, as a tool for people’s daily communication, has no gender bias itself. With the development of society, the language has changed correspondingly. Language serve as the mirror of society, inevitably reflecting people’s minds or ideology as well as the culture and social conditions of a society. While in English, as the mother tongue of many western countries, amounts of gender discrimination expressions are embodied. To some extent, the gender bias toward females serves as the embodiment that females are considerably insignificant and share a low social status. In this paper, the author will analyse the phenomenon of gender discrimination in English language, and find the reason behind it to make people realize the importance of eliminating this phenomenon. If people keep using sexism language unconsciously, it will become the hindrance of the social harmony
Dual-functional gum arabic binder for silicon anodes in lithium ion batteries
No full textSi has attracted enormous research and manufacturing attention as an anode material for lithium ion batteries (LIBs) because of its high specifi c capacity. The lack of a low cost and effective mechanism to prevent the pulverization of Si electrodes during the lithiation/ delithiation process has been a major barrier in the mass production of Si anodes. Naturally abundant gum arabic (GA), composed of polysaccharides and glycoproteins, is applied as a dualfunction binder to address this dilemma. Firstly, the hydroxyl groups of the polysaccharide in GA are crucial in ensuring strong binding to Si. Secondly, similar to the function of fi ber in fi berreinforced concrete (FRC), the long chain glycoproteins provide further mechanical tolerance to dramatic volume expansion by Si nanoparticles. The resultant Si anodes present an outstanding capacity of ca. 2000 mAh/g at a 1 C rate and 1000 mAh/g at 2 C rate, respectively, throughout 500 cycles. Excellent long-term stability is demonstrated by the maintenance of 1000 mAh/g specifi c capacity at 1 C rate for over 1000 cycles. This low cost, naturally abundant and environmentally benign polymer is a promising binder for LIBs in the future.Griffith Sciences, Griffith School of EnvironmentNo Full Tex
新加坡华语口语重叠式研究 = A study of reduplication in spoken Singapore Mandarin
No full text新加坡华语作为现代汉语的一种变体，在许多方面都有其特殊之处，而重叠便是其中一个方面。现今学界对于现代汉语重叠式的研究已相当成熟且丰富，但相比之下，新加坡华语口语的重叠式研究则稍显不够完善。因此，本文旨在深入且系统地探讨新加坡华语口语重叠式的可重叠范围、表达的语法意义和语用功能。目前为止，新加坡还未有一个实用的口语语料库，因此，笔者决定连同其他三位本科生一起建立一个口语语料库。本文大部分的新加坡华语口语重叠式例子和例句都是取自这个口语语料库。另外，本文除了利用口语语料库的数据分析重叠式之外，也将额外以问卷调查的形式，考察新加坡华语“VV一下”这一特殊结构。总的来说，通过本次研究，笔者发现新加坡特殊的重叠式主要集中在动词重叠、形容词重叠及名词重叠。其中，新加坡特殊的形容词重叠式出现的频率最高。此外，大多的特殊重叠式是受到闽南语的影响而形成的。Singapore Mandarin is, in many ways, different from the standard Modern Chinese, and reduplication is one of the aspects where Singapore Mandarin has exhibited its distinctiveness. Today, there exist many in-depth studies on reduplication in Modern Chinese. Yet, the study of reduplication in Singapore Mandarin paled in comparison. As such, this thesis aims to provide a systematic and thorough investigation on the scope, grammatical meaning and pragmatic functions of reduplications in Singapore Mandarin. As Singapore lacks database of spoken Singapore Mandarin, the author, along with 3 other undergraduates majoring in Chinese, constructed a corpus of spoken Singapore Mandarin together for the purpose of this study. In addition to the corpus data, a survey was also conducted to investigate the “VV yixia” structure that is exclusive to Singapore Mandarin. All in all, through this study, it was found that the unique forms of reduplication in Singapore Mandarin are mainly reduplicated verb, reduplicated adjective and reduplicated noun. Among the three, reduplicated adjective has the highest number of unique forms. It was also found that the unique reduplications were mostly influenced by the Hokkien dialect in Singapore.Bachelor of Art
Chinese insolvency law symposium : developing an insolvency infrastructure: 17-18 November 2000
No full textpublished_or_final_versionIntroductory materialsInstitutional reasoning in drafting new bankruptcy law of China Wang Weiguo Wang, We-guoRelationship between bankruptcy liquidation and ordinary liquidation of legal-person enterprise Wu Jingming Wu, Jing-mingReconsideration of the reorganization system in China's bankruptcy law and relevant issues Li Yongjun Li, Yong- junChinese bankruptcy law in an emerging market economy : the Shenzhen experience Xianchu Zhang Charles Booth Zhang, Xian-chu Booth, CharlesInsolvency of groups : problems involving parent companies and their affiliates Shi Jianzhong Shi, Jian- zhongCorporate group liability in insolvency - a Malaysian perspective Aiman Nariman Mohd-Sulaiman Mohd-Sulaiman, Aiman NarimanEvaluation of the draft of a new PRC insolvency law Ronald Harmer Harmer, RonaldA new insolvency infrastructure for the PRC Henry Pitney Pitney, HenryBasics of business reorganization in bankruptcy Steven Schwarcz Schwarcz, StevenOverview of insolvency law basics Steven Schwarcz Schwarcz, StevenAdministrative structure of the federal courts in the United States Lloyd George George, LloydThe UNCITRAL model law on cross-border insolvency Gerold Herrmann Herrmann, GeroldChinese cross-border insolvencies : current issues and future developments Shi Jingxia Shi, Jing-xiaPractical issues arising from Hong Kong SAR insolvency proceedings of companies with assets in mainland China Mark Hyde Hyde, MarkA commentary on cross-border insolvency issues Paul Heath Heath, PaulJapanese points of view to the draft Chinese insolvency law Shinjiro Takagi Takagi, ShinjiroAMCs and debt-equity swaps in China, can they really solve the state commercial bank NPL problem? Lou Jianbo Lou, Jian-boMainland China's accounting standards for debt structure Liu Yan Liu, YanBusiness reorganization in bankruptcy Mark Scarberry Scarberry, MarkChinese bankruptcy law for state-owned enterprises (1986)Chinese restructuringsCross-border insolvency articlesExcerpts from the Law Reform Commission of Hong Kong's report on the winding-up provisions of the Companies Ordinance (1999)The draft bankruptcy law of the People's Republic of Chin
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