795 research outputs found
JQ-1 restricts viral infection <i>in vivo</i>.
No full text(a) Experimental strategy for PRV-QXX challenge and JQ-1 treatment in mice. (b and c) IFN-β (b) and IL-1β (c) mRNA were assessed with RT-qPCR analysis in the lungs of mice (n = 4 per group). (d and e) IFN-β (d) and IL-1β (e) were quantified by ELISA in the serum in mice (n = 5 per group). (f) The survival rate was monitored daily for 10 days after PRV and PRV/JQ-1 challenge. (n = 12 per group). (g) The PRV genome was assessed with RT-qPCR analysis in the lungs of mice at 3 days post treatment of PRV and PRV/JQ-1 (n = 5 per group). (h) Experimental strategy for VSV-GFP challenge and JQ-1 treatment in mice. (i-k) The VSV genome was assessed with RT-qPCR analysis in the lung (i), spleen (j) and liver (k) of mice at 18 h post treatment of VSV and VSV/JQ-1 (n = 5 per group). (l) H&E stained images of lungs sections from mice treated as in g and i. Scale bar, 100 μM. All data are shown as mean ± SD based on three independent experiments. * P t-test.</p
A real-time information gathering agent based on ontology
No full textThis paper provides an agent based on an ontology that helps user to gather the real-time information. We present an approach of ontology representation based on concept graph and introduce the building and revising algorithms of knowledge base, then discuss the application of the ontology in information source representation. Experimental results show that the agent helps user accomplish the task effectively.Computer Science, Information SystemsComputer Science, Theory & MethodsSCI(E)CPCI-S(ISTP)
Data for: Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Non-erosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protocol
No full textData for: Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Non-erosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protoco
Data for: Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Non-erosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protocol
No full textData for: Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Non-erosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protoco
The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.
No full textBACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing enzymes. This study evaluated whether the polymorphisms in these enzymes were associated with an increased risk of anti-TB drug-induced hepatitis in patients and could potentially be used to identify patients at risk of liver injury. METHODS AND DESIGN: In a cross-sectional study, 2244 tuberculosis patients were assessed two months after the start of treatment. Anti-TB drug-induced liver injury (ATLI) was defined as an ALT, AST or bilirubin value more than twice the upper limit of normal. NAT2, CYP2E1, GSTM1 and GSTT1 genotypes were determined using the PCR/ligase detection reaction assays. RESULTS: 2244 patients were evaluated, there were 89 cases of ATLI, a prevalence of 4% 9 patients (0.4%) had ALT levels more than 5 times the upper limit of normal. The prevalence of ATLI was greater among men than women, and there was a weak association with NAT2*5 genotypes, with ATLI more common among patients with the NAT2*5*CT genotype. The sensitivity of the CT genotype for identifying patients with ATLI was 42% and the positive predictive value 5.9%. CT ATLI was more common among slow acetylators (prevalence ratio 2.0 (95% CI 0.95,4.20) )compared to rapid acetylators. There was no evidence that ATLI was associated with CYP2E1 RsaIc1/c1genotype, CYP2E1 RsaIc1/c2 or c2/c2 genotypes, or GSTM1/GSTT1 null genotypes. CONCLUSIONS: In Xinjiang Uyghur TB patients, liver injury was associated with the genetic variant NAT2*5, however the genetic markers studied are unlikely to be useful for screening patients due to the low sensitivity and low positive predictive values for identifying persons at risk of liver injury
Soliton solutions for quasilinear Schrodinger equations, I
No full textFor a class of quasilinear Schrodinger equations we establish the existence of ground states of soliton type solutions by a minimization argument.Mathematics, AppliedMathematicsSCI(E)95ARTICLE2441-44813
Transport property in narrow barrier GaAs/AlAs superlattice under hydrostatic pressure
No full textThe current-voltage (I-V) characteristics of a doped weakly coupled GaAs/AlAs superlattice (SL) with narrow barriers are measured under hydrostatic pressure from 1 bar to 13.5 kbar at both 77 and 300 K. The experimental results show that, contrary to the results in SL with wide barriers, the plateau in the I-V curve at 77 K does not shrink with increasing pressure, and becomes wider after 10.5 kbar. It is explained by the fact that the E-Gamma 1-E-Gamma 1 resonance peak is higher than the E-Gamma 1-E-X1 resonance peak. At 300 K, however, because of the more important contribution of the nonresonant component to the current, the plateau shrinks with increasing pressure. (C) 1999 American Institute of Physics. [S0021-8979(99)02008-3]
Suppression of self-sustained field domain oscillation in GaAs/AlAs superlattice by hydrostatic pressure at room temperature
No full textThe behavior of room temperature self-sustained current oscillations resulting from sequential resonance tunneling in a doped weakly-coupled GaAs/AlAs superlattice (SL) is investigated under hydrostatic pressure. From atmosphere pressure to 6.5 kbar, oscillations exist in the whole plateau of the I-V curve and oscillating characteristics are affected by the pressure. When hydrostatic pressure is higher than 6.5 kbar, the current oscillations are completely suppressed although a current plateau still can be seen in the I-V curve. The plateau disappears when the pressure is close to 13.5 kbar. As the main effect of hydrostatic pressure is to lower the X point valley with respect to Gamma point valley, the disappearance of oscillation and the plateau shrinkage before Gamma - X resonance takes place are attributed to the increases of thermoionic emission and nonresonant tunneling components determined by the lowest Gamma - X barrier height in GaAs/AlAs SL structure
THE CALCULATIONS OF LOW-ENERGY BEAM TRANSPORT
No full textAfter the ion beams are extracted from ion sources, it is necessary to transport the beams to the experimental areas or to the accelerating installations. Low-energy beam transport systems usually consist of some axially symmetrical electrostatic focusing and accelerating lenses as well as quadrupoles and dipoles. Here, we discuss the calculation methods for the beam transport in electrostatic lens systems and describe a computer program for this use.Instruments & InstrumentationPhysics, AppliedSCI(E)
Phylogeography and allopatric divergence in cypress species (Cupressus L.) in the Qinghai-Tibetan Plateau and adjacent regions
No full textAdditional files can be found at http://www.biomedcentral.com/1471-2148/10/194Background Although allopatric speciation is viewed as the most common way in which species originate, allopatric divergence among a group of closely related species has rarely been examined at the population level through phylogeographic analysis. Here we report such a case study on eight putative cypress (Cupressus) species, which each have a mainly allopatric distribution in the Qinghai-Tibetan Plateau (QTP) and adjacent regions. The analysis involved sequencing three plastid DNA fragments (trnD-trnT, trnS-trnG and trnL-trnF) in 371 individuals sampled from populations at 66 localities. Results Both phylogenetic and network analyses showed that most DNA haplotypes recovered or haplotype-clustered lineages resolved were largely species-specific. Across all species, significant phylogeographic structure (NST > GST, P < 0.05) implied a high correlation between haplotypes/lineages and geographic distribution. Two species, C. duclouxiana and C. chengiana, which are distributed in the eastern QTP region, contained more haplotypes and higher diversity than five species with restricted distributions in the western highlands of the QTP. The remaining species, C. funebris, is widely cultivated and contained very little cpDNA diversity. Conclusions It is concluded that the formation of high mountain barriers separating deep valleys in the QTP and adjacent regions caused by various uplifts of the plateau since the early Miocene most likely promoted allopatric divergence in Cupressus by restricting gene flow and fixing local, species-specific haplotypes in geographically isolated populations. The low levels of intraspecific diversity present in most species might stem from population bottlenecks brought about by recurrent periods of unfavorable climate and more recently by the negative impacts of human activities on species' distributions. Our findings shed new light on the importance of geographical isolation caused by the uplift of the QTP on the development of high plant species diversity in the QTP biodiversity hotspot.Peer reviewe
- …
