938 research outputs found
sj-docx-1-cpp-10.1177_15396754231199170 – Supplemental material for How network resources empower expert involvement? Evidence from urban planning decision-making in China
No full textSupplemental material, sj-docx-1-cpp-10.1177_15396754231199170 for How network resources empower expert involvement? Evidence from urban planning decision-making in China by Yuchen Guo, Huiling Xu and Shi Wu in Chinese Public Administration Review</p
Jian gou Mali. Xuelai zai "Ke xue guai ren" yu "Zui hou yi ren" zhong de "fan si xing jin bu zheng zhi xue"
No full textLiang, Huiling.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 84-90).Abstracts also in Chinese.Title from PDF title page (viewed on 26, September, 2016).Liang, Huiling
Supplemental Material2 - Supplemental material for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis
No full textSupplemental material, Supplemental Material2 for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis by Ling Guo, Linna Li, Yang Zhang, Shulin Fu, Jing Zhang, Xiuying Wang, Huiling Zhu, Mu Qiao, Lingying Wu and Yulan Liu in Innate Immunity</p
Supplemental Material1 - Supplemental material for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis
No full textSupplemental material, Supplemental Material1 for Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis by Ling Guo, Linna Li, Yang Zhang, Shulin Fu, Jing Zhang, Xiuying Wang, Huiling Zhu, Mu Qiao, Lingying Wu and Yulan Liu in Innate Immunity</p
sj-docx-1-dhj-10.1177_20552076231183544 - Supplemental material for Patients, carers and healthcare providers’ perspectives on a patient-owned surveillance system for diabetic foot ulcer care: A qualitative study
No full textSupplemental material, sj-docx-1-dhj-10.1177_20552076231183544 for Patients, carers and healthcare providers’ perspectives on a patient-owned surveillance system for diabetic foot ulcer care: A qualitative study by Zhiwen Joseph Lo, Bryan Chong, Elaine Tan, Desmond Ooi, Huiling Liew, Wai Han Hoi, Yuan Teng Cho, Kyle Wu, Naren Kumar Surendra, Maleyka Mammadova, Audrey Nah, Victor Goh and Josip Car in DIGITAL HEALTH</p
Topical hADSCs-HA Gel Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Paracrine Activating PPARβ/δ Pathway
No full textChaoying Jin,1,2,* Ruolin Zhao,3,4,* Weihang Hu,5 Xiaolong Wu,4 Li Zhou,6 Letian Shan,4,6 Huiling Wu1,2 1Department of Plastic and Aesthetic Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China; 2School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, People’s Republic of China; 3Yichen Biotechnology Co., Ltd, Hangzhou, Zhejiang, 311200, People’s Republic of China; 4Fuyang Academy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311403, People’s Republic of China; 5Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of China; 6The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Letian Shan; Huiling Wu, Email [email protected]; [email protected]: Pressure ulcer is common in the bedridden elderly with high mortality and lack of effective treatment. In this study, human-adipose-derived-stem-cells-hyaluronic acid gel (hADSCs-HA gel) was developed and applied topically to treat pressure ulcers, of which efficacy and paracrine mechanisms were investigated through in vivo and in vitro experiments.Methods: Pressure ulcers were established on the backs of C57BL/6 mice and treated topically with hADSCs-HA gel, hADSCs, hyaluronic acid, and normal saline respectively. The rate of wound closure was observed continuously during the following 14 days and the wound samples were obtained for Western blot, histopathology, immunohistochemistry, and proteomic analysis. Human dermal fibroblasts (HDFs) and human venous endothelial cells (HUVECs) under normal or hypoxic conditions were treated with conditioned medium of human ADSCs (ADSC-CM), then CCK-8, scratch test, tube formation, and Western blot were conducted to evaluate the paracrine effects of hADSCs and to explore the underlying mechanism.Results: The in vivo data demonstrated that hADSCs-HA gel significantly accelerated the healing of pressure ulcers by enhancing collagen expression, angiogenesis, and skin proliferation. The in vitro data revealed that hADSCs strengthened the proliferation and wound healing capabilities of HDFs and HUVECs, meanwhile promoted collagen secretion and tube formation through paracrine mode. ADSC-CM was also proved to exert protective effects on hypoxic HDFs and HUVECs. Besides, the results of proteomic analysis and Western blot elucidated that lipid metabolism and PPARβ/δ pathway mediated the healing effect of hADSCs-HA gel on pressure ulcers.Conclusion: Our research showed that topical application of hADSCs-HA gel played an important role in dermal regeneration and angiogenesis. Therefore, hADSCs-HA gel exhibited the potential as a novel stem-cell-based therapeutic strategy of treating pressure ulcers in clinical practices. Keywords: pressure ulcer, wound healing, human adipose derived stem cell, hydrogel, PPARβ/δ, lipid metabolism, skin regeneratio
Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells
No full textJing Zhang,1 Kai Wu,2 Ting Xu,3 Jiajun Wu,1 Pengfei Li,1 Hong Wang,4 Huiling Wu,1 Gang Wu5 1Department of Plastic and Aesthetic Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China; 2Spine Lab, Department of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China; 3Department of Stomatology, First Affiliated Hospital, Zhejiang University, Hangzhou, China; 4Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Centre, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, North Holland, the Netherlands; 5Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, North Holland, the Netherlands Purpose: The aim of this study is to investigate the effects of epigallocatechin-3-gallate (EGCG), a major polyphenol extracted from green tea, on the osteoblastogenic differentiation of human adipose-derived stem cells (hASCs).Patients and methods: hASCs were acquired from human adipose tissue. With informed consent, subcutaneous adipose tissue samples were harvested from periorbital fat pad resections from ten healthy female adults who underwent double eyelid surgery. hASCs were cultured in osteogenic medium with or without EGCG (1 µM, 5 µM, or 10 µM) for 14 days. We evaluated the effects of EGCG by quantifying cell growth, ALP activity (an early osteoblastogenic differentiation marker), BSP, OCN (a late osteoblastogenic differentiation marker), and extracellular matrix mineralization. We also performed Western blots to measure osteoblastogenesis-related proteins such as Runx2 and adipoblastogenesis-related transcription factors, such as STAT3, C/EBP-α, and PPAR-γ.Results: EGCG at 5 µM resulted in significantly higher cell proliferation and ALP activity than did the control on days 3, 7, and 14. On day 7, 5 µM EGCG significantly enhanced BSP expression. On day 14, EGCG at all concentrations promoted OCN expression. In addition, EGCG at 5 µM resulted in the highest level of extracellular matrix mineralization. On day 3, the expression levels of Runx2 were significantly higher in the 5 µM EGCG group than in the other groups, whereas later, on days 7 and 14, Runx2 expression levels in the EGCG group were significantly lower than those of the control group. EGCG at all three concentrations was associated with significantly lower levels of phosphorylated STAT3, C/EBP-α, and PPAR-γ.Conclusion: EGCG at 5 µM significantly enhanced the osteoblastogenic differentiation of hASCs. Keywords: EGCG, hASCs, osteoblastogenesis, STAT3, bone regeneratio
Optimal Investment-Consumption Strategy under Inflation in a Markovian Regime-Switching Market
No full textThis paper studies an investment-consumption problem under inflation. The consumption price level, the prices of the available assets, and the coefficient of the power utility are assumed to be sensitive to the states of underlying economy modulated by a continuous-time Markovian chain. The definition of admissible strategies and the verification theory corresponding to this stochastic control problem are presented. The analytical expression of the optimal investment strategy is derived. The existence, boundedness, and feasibility of the optimal consumption are proven. Finally, we analyze in detail by mathematical and numerical analysis how the risk aversion, the correlation coefficient between the inflation and the stock price, the inflation parameters, and the coefficient of utility affect the optimal investment and consumption strategy
Mali Xuelai xiao shuo zhong de "dao de de zi wo"
No full textPh.D.In Shelley scholarship, there has been controversy as to whether Shelley is radical or conservative, feminist or ambivalent towards feminine self-assertion. There has also been disagreement over the extent to which she is critical of key Romantic ideas, especially that of transcendence. This thesis argues that Shelley is neither conventional nor contrarian. It contends that Shelley celebrates a notion of what I call the ethical self: an individual self that is able to maintain an ongoing exchange between opposite yet interrelated aspects of human life, such as freedom and duty, passion and reason, transcendence and domesticity, romance and reality, romance and history. The notion "exchange" is characterised by a kind of tempered or moderate dialecticism, which is concerned with mediating or balancing contrary, yet complimentary aspects of human life through the qualification of one aspect by its contrary.Chapter One focuses on Frankenstein. It argues that Shelley upholds the radical perspective of political monstrosity that attributes human monstrosity to the lack of freedom in society. It also contends that unqualified individual freedom or unqualified moral duty can lead to monstrosity. Moreover, it looks into the role passion plays in the formation of morality, and the disastrous effects of excessive passions. Finally, it explores both the egotistical and humanitarian aspects of Wordsworthian transcendence, P. B. Shelley's notion of transcendence, and Shelley's notion of what I call interconnected transcendence.Chapter Two is about Valperga. It suggests that Euthanasia places morality and humanity above historical circumstances and one's political identity. It also examines Euthanasia's notion of spiritual freedom, and how her freedom is qualified by a sense of duty towards her city-state, and more importantly, towards humanity. Additionally, this chapter explores the ongoing mediation between reason and passion, reason and imagination. Lastly, it probes how Shelley critiques the transcendence the Byronic hero seeks through individual heroism, as well as the Byronic vision of love that transcends morality or humanity.Chapter Three concerns Lodore. It argues that Shelley is critical of the aristocratic code of honour and the practice of dueling. It also contends that Byronic individualism is contradictory and theatrical in the sense that he needs the world to reject the world. This chapter also demonstrates Cornelia's transformation, suggesting that her new feeling of freedom is accompanied by a genuine sense of duty towards her daughter. Furthermore, it explores Fanny's self-affirming dialecticism between independence and duty, and Ethel's, between romance and reality.Chapter Four studies Falkner. It contends that the Byronic Falkner regards life as a self-directing drama in which he plays the role of a rebellious and remorseful hero. Moreover, Falkner's individualistic reading is unqualified by empathetic imagination, whilst Gerard's empathetic reading of Hamlet is unqualified by an awareness of the differences between him and Hamlet. Lastly, this chapter argues that Elizabeth's fidelity is based on her ethical self.This thesis concludes that the notion of the ethical self allows us to see how Shelley qualified and critiqued the ideas she was influenced by, and, in so doing, made them her own.在雪萊的研究中，對於她是激進還是保守，是支持女權主義還是對女性自我表達有搖擺不定的态度，乃至她對浪漫主義思想的批評，尤其是關於超越的思想，學界都有爭議。本論文提出雪萊並非傳統，也非反傳統，而是堅持一種思想，我稱之為道德的自我。其意思是，作為個體的自我，有能力對人類生活中對立而互聯的各方面, 例如自由與責任、情感與理性、超脫的精神世界與踏實的家庭生活、浪漫式的想象與現實、以及傳奇文學與歷史，持续進行辯證式的互相交流，這種溫和的辯證思想旨在調節或平衡對立的兩方。第一章研究《科學怪人》。雪萊支持激進派對於“醜惡/怪物”這個政治比喻的看法，將人性的醜惡歸咎於缺乏自由的社會。但是，她認為過分的個人自由或者過分的道德責任都會導致人性的醜惡。此章也探討了情感對於道德觀形成的作用，以及過分的情感會造成的嚴重後果。此章還討論了華茲華斯式精神超越的兩個方面 - 自我為中心和人道主義，珀西·比希·雪萊式的超越，以及雪莱對超越的看法，我稱之為互连的超越。第二章是關於《瓦爾伯加》。此章探討了尤瑟尼西亞對精神自由的理解。此外，她的個人自由與她對城邦乃至對人道的責任是互相修正的。此章也討論了理性與情感、理性與想象力之間的互相調節。最後，此章探討了拜伦式英雄通過個人英雄主義而達到的一種超越，以及拜倫式的超越道德或人道的愛情觀。第三章關於《洛多尔》。雪萊批判了貴族的榮譽準則以及決鬥這種行為。此章提出拜倫式個人主義的矛盾性和戲劇性，就是說，他需要這個世界作為觀眾，看他如何拒絕這個世界。此章還探討了芬妮在獨立和責任之間的辯證，以及艾瑟兒在浪漫式的想象與現實之間的辯證，這些辯證都是自我肯定的。第四章研究《福克納》。拜倫式的福克納把人生看做一部自導自演的戲劇，他飾演一個反叛和充滿悔恨的英雄。福克納的個性化閱讀缺乏共情想象，而傑拉德對哈姆雷特的共情閱讀沒有意識到自己跟哈姆雷特的不同。最後一個論點是，伊麗莎白的忠誠是基於她的道德的自我。本論文的結論是“道德的自我”這個觀點能夠讓我們了解雪萊是如何通過修正和批判那些對她有影響的思想，從而將那些思想轉化成她自己的見解。Liang, Huiling.Thesis Ph.D. Chinese University of Hong Kong 2020.Includes bibliographical references (leaves 245-262).Abstracts also in Chinese.Title from PDF title page (viewed on November 5, 2021).Liang, Huiling
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