198 research outputs found
sj-pdf-1-jtr-10.1177_00472875231177229 – Supplemental material for e-Tourism Information Literacy and Its Role in Driving Tourist Satisfaction With Online Travel Information: A Qualitative Comparative Analysis
No full textSupplemental material, sj-pdf-1-jtr-10.1177_00472875231177229 for e-Tourism Information Literacy and Its Role in Driving Tourist Satisfaction With Online Travel Information: A Qualitative Comparative Analysis by Rui Wang, Chuanhui Wu, Xia Wang, Feifei Xu and Qinjian Yuan in Journal of Travel Research</p
sj-pdf-1-jcb-10.1177_0271678X221111852 - Supplemental material for Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy
No full textSupplemental material, sj-pdf-1-jcb-10.1177_0271678X221111852 for Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy by Xian Wang, Xiaoyin Wang, Jin Ma, Milan Jia, Longfei Wu, Weili Li, Chuanhui Li, Chuanjie Wu, Changhong Ren, Xin Chen, Wenbo Zhao and Xunming Ji in Journal of Cerebral Blood Flow & Metabolism</p
sj-pdf-1-wso-10.1177_17474930211040923 - Supplemental material for Basilar Artery Occlusion Chinese Endovascular Trial: Protocol for a prospective randomized controlled study
No full textSupplemental material, sj-pdf-1-wso-10.1177_17474930211040923 for Basilar Artery Occlusion Chinese Endovascular Trial: Protocol for a prospective randomized controlled study by Chuanhui Li, Chuanjie Wu, Longfei Wu, Wenbo Zhao, Jian Chen, Ming Ren, Chen Yao, Xiaoyan Yan, Chongya Dong, Haiqing Song, Qingfeng Ma, Jiangang Duan, Yunzhou Zhang, Hongqi Zhang, Liqun Jiao, Yuping Wang, Tudor G Jovin, Xunming Ji and on behalf of the BAOCHE Investigators in International Journal of Stroke</p
JCB903697 Supplemental Material - Supplemental material for Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status
No full textSupplemental material, JCB903697 Supplemental Material for Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status by Di Wu, Jian Chen, Mohammed Hussain, Longfei Wu, Jingfei Shi, Chuanjie Wu, Yanhui Ma, Mo Zhang, Qi Yang, Yongjuan Fu, Yunxia Duan, Cui Ma, Feng Yan, Zixin Zhu, Xiaoduo He, Tianqi Yao, Ming Song, Xinglong Zhi, Chunxiu Wang, Lipeng Cai, Chuanhui Li, Shengli Li, Yongbiao Zhang, Yuchuan Ding and Xunming Ji in Journal of Cerebral Blood Flow & Metabolism</p
Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma
Get PDFLiting Zhong,1,2,* Weiwei Peng,1,2,* Jingyuan Sun,3 Yongyi Luo,3 Hailong Sheng,4 Yi Wu,5 Tonggang Zhou,5 Chaoming Zhou,1,2 Chuanhui Cao1,3 1Department of Oncology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi, People’s Republic of China; 2Department of Oncology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, People’s Republic of China; 3Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Interventional Radiology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanhui Cao, Department of Oncology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, No. 16 Meiguan Avenue, Ganzhou, Jiangxi, People’s Republic of China, Email [email protected]: The optimal timing for combining radiotherapy with immunotherapy in patients with hepatocellular carcinoma (HCC) remains uncertain and affects treatment efficacy and patient outcomes. This study aimed to evaluate and compare the efficacy and treatment-related adverse events (TRAEs) of synchronously administered radiotherapy and programmed cell death protein (PD)-1 inhibitors and sequential administration in patients with HCC.Patients and Methods: We retrospectively enrolled 67 patients with HCC who were undergoing liver radiotherapy and PD-1 inhibitor therapy at two medical centers between July 2017 and April 2023. Additionally, we created an experimental tumor model using 6-week-old female mice to validate our findings.Results: In the concurrent group, the median overall survival was indefinite; however, it was 13 months in the sequential group (95% confidence interval [CI] 6.7– 19.3 months, P=0.010). The median progression-free survival was significantly longer in the concurrent group (12 months, 95% CI 9.5– 14.5 months) than in the sequential group (7 months, 95% CI 1.3– 12.7 months; P=0.043). Grade 3/4 TRAEs occurred in 30.4% (concurrent) and 28.6% (sequential) of patients without any treatment-related deaths. In the mouse model, synchronous treatment significantly inhibited tumor growth compared to sequential treatment (293.4± 45.18 mm3 versus 602.7± 41.68 mm3; P=0.001). Flow cytometry revealed an increased Tregs/CD3+ T cell ratio and a decreased CD8+/Treg cell ratio post-radiotherapy, suggesting an immunosuppressive tumor microenvironment.Conclusion: Synchronous treatment demonstrated superior efficacy in treating HCC compared to sequential treatment, with manageable adverse events. The rapid increase in Tregs after radiotherapy may contribute to the reduced efficacy of sequential radiotherapy plus PD-1 inhibitors.Keywords: immunotherapy, treatment efficacy, adverse events, tumor microenvironmen
The constitutional protection of private property in China ::historical evolution and comparative research /
No full textThis timely book reviews the changes in legal reform around the constitutional protection of private property in China since 1949. Using a comparative approach, it analyses the development of property theories and the various constitutionalisation models and practices of private property in representative countries including the United States, Canada, Germany, India and China. It also explores the interwoven social forces that have been driving the evolution of the constitutional protection of private property in China. By comparing China with the United States, Germany and India, the author reveals the unfairness, unjustness and insufficiency in China's application of three constitutional doctrines ́ђأ public use, just compensation and due process or procedure. The book concludes by predicting future progress and suggests feasible measures for gradual reform that will be compatible with China's existing political system
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