437 research outputs found
Association between T2D PRS (T2D PRS) and selected variables included in analyses.
No full textPRS, polygenic risk score; T2D, type 2 diabetes. (XLSX)</p
PRS Weight Tables for Nine Traits using LDpred2-auto
No full textThe rds file contains a list of data frames, corresponding to PRS weight tables for nine traits.
Single nucleotide polymorphism (SNP)-based Polygenic Risk Scores (PRS) were calculated with data obtained from Illumina GSA chip (v2), ambiguously oriented SNPs were excluded. Genetic data were imputed by the Minimac4 tool with the HRC r1.1 (European panel). PRS for schizophrenia (Trubetskoy et al. 2022), bipolar disorder (including separately type I and type II, Mullins et al. 2021), autism (Grove et al. 2019), epilepsy (focal and GGE, ILAEC 2022), ADHD (Demontis et al. 2019), and height (Yengo et al. 2018) were inferred with LDpred2-auto tool (Privé et al. 2020) available in the R package “bigsnpr” (v1.12.2). We followed a guide from the method’s author (https://privefl.github.io/bigsnpr/articles/LDpred2.html). An in-house sample (n=1638) collected in the laboratory of Clinical Genetics, Mental Health Research Center, predominantly consisting of individuals of Slavic descent from the Moscow region, was employed as the LD reference. All samples consisted of unrelated individuals. No covariates were incorporeted into the PRS calculations. Both control and SZ patient samples were similar in terms of gender and ethnicity.</p
Mean T2D PRS in women with GDM.
No full textMean T2D PRS in women with GDM who subsequently did and did not develop T2D, compared to age- and BMI-matched control groups of females without GDM, and males. Data are presented as group mean with 95% CIs according to sex-by-GDM subgroup, stratified by subsequent T2D status. BMI, body mass index; CI, confidence interval; GDM, gestational diabetes mellitus; PRS, polygenic risk score; T2D, type 2 diabetes.</p
Difference in average PRS scores (95% CI) by whether participant had observed or missing BMI scores at a given age.
No full textDrawn from separate regressions for each combination of PRS score (columns) and age of follow-up (rows). (DOCX)</p
List of variants used in the T2D PRS for G&H.
No full textG&H, Genes & Health; PRS, polygenic risk score; T2D, type 2 diabetes. (XLSX)</p
Distribution of previously reported glycaemic trait PRS and wGRS across clusters in the Integrated Model.
No full textPRS, polygenic risk score; wGRS, weighted genetic risk scores. (XLSX)</p
Characteristics of individuals used to construct T2D PRS in G&H.
No full textG&H, Genes & Health; PRS, polygenic risk score; T2D, type 2 diabetes. (XLSX)</p
Authors', Institutions' and Countries' rankings in regional and urban science : an analysis for nine top international journals from 1991 to 2000
No full textThis paper examines the most productive authors, institutions and countries in regional and urban science from 1991 to 2000 using information on published articles (and pages) from a sample of widely recognized journals in this field: ARS, JUE, JRS, IJURR, IRSR, PRS, RSUE, RS and US. We also consider the relation between the country of the institution named in articles and the country in which the journal is published, in order to know if there are a home publication bias in regional and urban science. Analysis was made for the whole decade and by subperiods, this allowed us to make a more dynamic interpretation of the results- El siguiente artículo examina los autores, instituciones y paises más productivos en la ciencia regional y urbana desde 1991 hasta 2000 usando información sobre artículos publicados de una muestra de revistas ampliamente reconocida en este campo: ARS, JUE, JRS, IJURR, IRSR, PRS, RSUE, RS y US. También se analiza la relación existente entre el país de la institución en que el autor desarrolla su investigación y el país de edición de las revistas donde se publican los trabajos con el objetivo de analizar si existe ¿sesgo doméstico¿. El análisis se realiza para toda la década y por subperíodos lo que permite una interpretación dinámica de los resultado
PULSE SHAPE, EXCESS BANDWIDTH, AND TIMING ERROR SENSITIVITY IN PRS SYSTEMS - COMMENT
No full textSeveral non-minimum-bandwidth partial-response-signaling (PRS) techniques were compared in the above paper (ibid., vol.COM-35, p.475-80, April 1987). One of the criteria used for the comparison was the robustness to the timing jitter. The commenter shows that according to this criterion the duobinary signaling technique is superior to the dicode scheme at low values of the roll-off factor, in contradiction to the conclusion in the original study. In reply the author agrees that the comment is correct and that unnormalized and normalized figure-of-merit plots show different aspects of timing jitter sensitivity as a function of excess bandwidth
Authors', Institutions' and Countries' rankings in regional and urban science. An analysis for nine top international journals from 1991 to 2000
No full textThis paper examines the most productive authors, institutions and countries in regional and urban science from 1991 to 2000 using information on published articles (and pages) from a sample of widely recognized journals in this field: ARS, JUE, JRS, IJURR, IRSR, PRS, RSUE, RS and US. We also consider the relation between the country of the institution named in articles and the country in which the journal is published, in order to know if there are a home publication bias in regional and urban science. Analysis was made for the whole decade and by subperiods, this allowed us to make a more dynamic interpretation of the results.rankings, regional and urban research, bibliometric analysis
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