2,929 research outputs found
Portrait of Helen Hunt Jackson painted by A.F. Harmer in 1885, ca. 1885
No full textPhotograph of a portrait of Helen Hunt Jackson painted by A.F. Harmer in 1885, ca. 1885. She is turned slightly to the right and is visible from the chest up. She is wearing a high collared light-colored ruffled blouse under a dark dress. The portrait is signed with the artist's initials, "A.F.H.". Jackson was the author of the book "Ramona." Possibly painted from sittings in 1880 or 1882
Design metrics for evaluating the propulsive efficiency of future ships
No full textThere is an increasing need for the ship design process to take account of environmental issues such as the emission of greenhouse gases and the likely extension of a carbon dioxide charging mechanism to international shipping. These issues, together with the need for economic viability, provide further incentives to improve the efficiency of propulsion of ships. The main components of powering are firstly reviewed. Individual components and other power saving devices are identified which should contribute to improvements in the overall efficiency of propulsion. Suitable design metrics and procedures, taking into account economic and environmental factors, are recommended for the design of future ships
Design and implementation of the Delft molecular-dynamics processor
No full textApplied SciencesApplied Science
Un’esperienza didattica in tema di paleonutrizione
No full textThe item arises from an "elective" Paleopathology course suggested for students graduating in Medicine and Surgery at the University of Milan. This course discussed subjects as: molecular paleobiology, tumors and infectious paleopathology, paleonutrition, paleopathological museums and history of medicine. The author dealt with the "paleonutrition" subject. Extremely actual aspects emerged which drew the students' attention
Strategische alliantie voor Esprithuis: Strategische allianties als organisatie- en rechtsvorm van samenwerkingsverbanden in de bouw
No full textSamenwerkingsverbanden binnen de bouw krijgen steeds meer aandacht. De studies naar projectallianties door de faculteit Bouwkunde van de Technische Universiteit Delft zijn daar een voorbeeld van. Door de kennis over projectallianties rijst de vraag of projectoverstijgende alliantie - zogenaamde strategische allianties - bruikbare samenwerkingsverbanden kunnen zijn voor ondernemingen in de bouw. Vereniging EspritHuis is een bedrijvenvereniging die op basis van mass customization woningen wil gaan bouwen. Mass customization vraagt van de aanbiedende partij(en) een vergaande uitwisseling van informatie over de verschillende producten die worden aangeboden. De klant krijgt in een mass customized project namelijk de vrijheid om - binnen de (ruime) grenzen van de aanbieder - zijn of haar woonwensen te realiseren. De ontwikkelingen die door Vereniging EspritHuis zijn getieerd vragen van de deelnemers aan de ontwikkeling een intensieve en langdurige samenwerking. De doelen van het ontwikkelingsproces van Vereniging EspritHuis heeft sterke parallellen met de algemene eigenschappen van een strategische alliantie. De probleemstelling van dit rapport is daarom als volgt. Gezien de eerder geschetste situatie is het waardevol de strategische alliantie als organisatie- en contractmodel te onderzoeken en te beschouwen of deze is toe te passen op procesgroep EspritHuis, die op basis van mass customization een nieuw bouwproduct op de markt wil zetten. Vanuit het huidige organisatiemodel van EspritHuis is - om alle deelnemers aan de ontwikkeling te laten wennen aan de verhoudingen binnen een strategische alliantie - een stappenplan opgesteld voor de groei naar een model wat past binnen strategische allianties. Daarnaast is op basis van de nieuwe wetgeving voor personenvennootschappen een keuzeschema opgesteld om de juiste rechtsvorm te kiezen voor de strategische alliantie. Vanuit de mededingingswetgeving is niet te verwachten dat EspritHuis beperkingen zal worden opgelegd.Architectur
Environmental epigenetics : a role in endocrine disease?
No full textAbstract
Endocrine disrupting chemicals that are structurally similar to steroid or amine hormones have the potential to mimic endocrine endpoints at the receptor level. However, more recently, epigenetic-induced alteration in gene expression has emerged as an alternative way in which environmental compounds may exert endocrine effects. We review concepts related to environmental epigenetics and relevance for endocrinology through three broad examples: 1) effect of early-life nutritional exposures on future obesity and insulin resistance, 2) effect of lifetime environmental exposures such as ionizing radiation on endocrine cancer risk, and 3) potential for compounds previously classified as endocrine disrupting to additionally or alternatively exert effects through epigenetic mechanisms. The field of environmental epigenetics is still nascent, and additional studies are needed to confirm and reinforce data derived from animal models and preliminary human studies. Current evidence suggests that environmental exposures may significantly impact expression of endocrine-related genes and thereby affect clinical endocrine outcomes
Cancer risk in patients with constitutional chromosome deletions: a nationwide British cohort study
No full textThe finding of increased risks of specific cancers in individuals with constitutional deletions of chromosomes 11p and 13q led to the discovery of cancer predisposition genes at these locations, but there have been no systematic studies of cancer risks in patients with constitutional deletions, across the chromosome complement. Therefore, we assessed cancer incidence in comparison with national cancer incidence rates in a follow-up of 2561 patients with constitutional autosomal chromosome deletions diagnosed by microscopy or fluorescence in situ hybridisation in Britain during the period 1965-2002. Thirty cancers other than non-melanoma skin cancer occurred in the cohort (standardised incidence ratio (SIR)=2.4, 95% confidence interval (CI) 1.6-3.5). There were significantly increased risks of renal cancer in persons with 11p deletions (SIR=1869, 95% CI 751-3850; P=4 x 10(-21)), eye cancer with 13q deletions (SIR=1084, 95% CI 295-2775; P=2 x 10(-11)), and anogenital cancer with 11q deletions (SIR=305, 95% CI 63-890; P=3 x 10(-7)); all the three latter cancers were in the 11 subjects with 11q24 deletions. The results strongly suggest that in addition to suppressor genes relating to Wilms' tumour risk on 11p and retinoblastoma on 13q, there are suppressor genes around 11q24 that greatly affect anogenital cancer ris
Liberating the modern Chinese football fan: a theoretical perspective
No full textThe cultural and philosophical heritage of modernism underpinning general marketing
management theory imparts profound implications for organisations operating in professional sport. This theoretical paper uses the context of China’s professional football industry to argue that marketing may benefit from a more postmodern approach to marketing management
Aspects of the circulation in the Rockall Trough
No full textAn investigation is made of the circulation and structure of the water masses in the Rockall Trough in spring, combining the results of a recent synoptic survey (May 1998) with those from a high-resolution ocean circulation model. In the near-surface layer, saline flows are carried northwards by a "Shelf Edge Current" around the eastern slopes, possibly with some branching in the northern Trough. Fresher waters from the west inflow between 52 and 538N and partially mix with these saline flows in the southern Trough, so that waters of intermediate salinity are also swept northwards. In the southern approaches to the Trough, Labrador Sea Water (LSW) also flows strongly in from the west between 52 and 538N, and while much of this turns south, a proportion penetrates north to join a cyclonic gyre in the Trough extending to 56.58N. The northwestern limb of this gyre is fed by, and mixes with, more saline waters which result from overflows across the Wyville–Thomson Ridge. Furthermore, salinity and CFC data suggest episodic inflow of LSW into the central Trough. The circulation of the North East Atlantic Deep Water in the Trough follows a cyclonic pattern similar to, and lying below, that of the LSW. The Wyville–Thomson Ridge overflows in the model extend to higher densities than in the survey, are topographically steered southwestward down the Feni Ridge system, and eventually join a deep cyclonic circulation in the North East Atlantic basin. Overall, the model and the observations are in good agreement, particularly in the central Rockall Trough, and this has allowed conclusions to be drawn which are significantly more robust than those which would result from either the survey or the model alone. In particular, we have been able to infer cyclonic circulation pathways for the intermediate and deeper waters in the Rockall Trough for (we believe) the first time. The study has also contributed to an ongoing community effort to assess the realism of, and improve, our current generation of ocean circulation models
Author Correction:A cattle graph genome incorporating global breed diversity
No full textThe original version of this Article omitted from the author list the 12th and 13th authors Dennis Muhanguzi and Wilson Amanyire, who are from the ‘School of Biosecurity, Biotechnology and Laboratory Sciences (SBLS), College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O Box 7062, Kampala, Uganda’. Consequently, the final sentence of the Author Contributions incorrectly read ‘D.W., P.T., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been replaced with ‘D.W., P.T., W.A., D.M., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been corrected in both the PDF and HTML versions of the Article
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