1,113 research outputs found
A survey of the research of J. Neville Birdsall
No full textA personal reflection on the life and works of J. Neville Birdsall by the author himself
A review of mechanistic studies on aromatase (CYP19) and 17?-hydroxylase-17,20-lyase (CYP17)
No full textIn the conventional P-450 dependent hydroxylation reaction, the FeIII resting state of the enzyme, by a single electron transfer, is reduced to FeII, which reacts with O2 to produce a FeIII–O–O intermediate. The latter following the transfer of another electron furnishes a ferric-peroxyanion, FeIII–O–O?, which after protonation leads to the fission of the O–O bond resulting in the formation of FeVO, the key player in the hydroxylation process. Certain members of the P-450 family, including CYP17 and CYP19, catalyze, at the same active site, not only the hydroxylation process but also an acyl–carbon bond cleavage reaction which has been interpreted to involve the nucleophilic attack of the ferric-peroxyanion, FeIII–O–O?, on the acyl carbon to furnish a tetrahedral intermediate which fragments, leading to acyl–carbon cleavage. Evidence is presented to show that in the case of CYP17 the attack of FeIII–O–O? on the target carbon is promoted by cytochrome b5, which acts as a conformational regulator of CYP17. It is this regulation of CYP17 that provides a safety mechanism which ensures that during corticoid biosynthesis, which involves 17?-hydroxylation by CYP17, androgen formation is avoided. Finally, a brief account is presented of the inhibitors, of the two enzymes, which have been designed on the basis of their mechanism of action
Miss Maude Neville
No full textMiss Maude Neville, society editor of the Paris News, sitting at a desk. She is wearing a dress. On the desk is a typewriter, telephone, box of tissues and various documents. She is the daughter of Mr. Alexander White Neville, editor-in-chief of the Paris News. She is one of the three Neville children who have followed in their father\u27s professional footsteps. One is employed at Houston and another is author of a syndicated newspaper feature. Published Fort Worth Star-Telegram Morning Edition March 3, 1940.https://mavmatrix.uta.edu/specialcollections_startelegram1940s/1690/thumbnail.jp
Catalogue of valuable pictures and drawings, by old masters of the Italian, dutch & Flemish schools ... Anthony J. Wright Biddulph, (decd) ... the property of Sir John Child ... G.H. Bodley ... pictures mainly of the English and French schools, and English drawings in pastel ... portraits in pastel ... an important collection of thirty-three portrait studies by John Downman ... the property of the Hon. Mrs. Ralph Neville ... Col. Eustace Hill ... sporting pictures and naval actions, the property of Capt. of McCullum ... Mrs. Bucknill ... and ... Capt. H.W. Murray ... which will be sold by auction by Messrs. Sotheby and Co. ... at their large galleries ... on Wednesday, the 9th of December, 1931 ... /
No full textNiet geannoteerdCover title: Catalogue of pictures and drawings ... Anthony J. Wright Biddulph, deceased ... Sir John Child ... G.H. Bodley ... the Hon. Mrs. Ralph Neville ... Col. Eustace Hill ... Capt. McCullum ... Mrs. Bucknill ... Capt. H.W. Murray and other properties.Price list tipped in
Our birds /
No full text1st ed. Cover ill.; Also available online at: http://nla.gov.au/nla.aus-vn758015; Library's copy signed by the author, and inscribed: "With the publishers compliments"
Neville-Jones, Milošević, Izetbegović, and Tuđman at the Signing of the Dayton Peace Agreement
No full textBritish representative Pauline Neville-Jones, Serbian President Slobodan Milošević, Bosnian President Alija Izetbegović, and Croatian President Franjo Tuđman sitting at the table at the Dayton Peace Agreement signing at Wright-Patterson Air Force Base.https://corescholar.libraries.wright.edu/special_ms458_photographs/1083/thumbnail.jp
Neville-Jones, Milošević, Izetbegović, and Tuđman Sit at Dayton Peace Accords Signing Table
No full textBritish representative Pauline Neville-Jones, Serbian President Slobodan Milošević, Bosnian President Alija Izetbegović, and Croatian President Franjo Tuđman sit at the signing table at the Dayton Peace Accords, held at Wright-Patterson Air Force Base.https://corescholar.libraries.wright.edu/special_ms458_photographs/1144/thumbnail.jp
Neville-Jones, Milošević, Izetbegović, and Tuđman at the Signing of the Dayton Peace Agreement
No full textBritish representative Pauline Neville-Jones, Serbian President Slobodan Milošević, Bosnian President Alija Izetbegović, and Croatian President Franjo Tuđman sitting at the table at the Dayton Peace Agreement signing at Wright-Patterson Air Force Base.https://corescholar.libraries.wright.edu/special_ms458_photographs/1082/thumbnail.jp
Neville-Jones, Milošević, Izetbegović, and Tuđman Sit at Dayton Peace Accords Signing Table
No full textBritish representative Pauline Neville-Jones, Serbian President Slobodan Milošević, Bosnian President Alija Izetbegović, and Croatian President Franjo Tuđman sit at the signing table at the Dayton Peace Accords, held at Wright-Patterson Air Force Base.https://corescholar.libraries.wright.edu/special_ms458_photographs/1145/thumbnail.jp
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