4,735 research outputs found
Helen Wright, secretary to the President of CAT
No full textHelen Wright, secretary to the President of CAT
Regulation of domestic cat ownership to protect urban wildlife: a justification based on the precautionary principle
No full textWhile it is undeniable that both feral cats and owned domestic cats prey on native wildlife, evidence that this is a threat to the viability of wildlife populations is contentious, particularly in the suburbs. Where uncertainty is great or the risks are high, the precautionary principle is a guide as to whether or not action should be taken to regulate domestic cats This involves an evaluation of the available evidence and the extent of uncertainty, as well as consideration of the viewpoints of major stakeholders. Applying this approach leads to the conclusion that wildlife can be protected while improving cat welfare, Containing cats at night not only separates cats and nocturnal wildlife, but minimises trauma from both cat fights and road accidents while reducing nuisance to neighbours from caterwauling and fighting. Desexed cats no longer contribute toward unwanted stray and feral cat populations that depredate native wildlife populations and are often less of a nuisance to neighbours and themselves as spraying and fighting are reduced. Cats with identification can be returned to their owners should they be found lost or injured, while problem cats can be identified. Therefore, the cat welfare issue is the key to a successful precautionary approach because it achieves wildlife protection while respecting the interests of cat owners
Property A and CAT(0) cube complexes
No full textProperty A is a non-equivariant analogue of amenability defined for metric spaces. Euclidean spaces and trees are examples of spaces with Property A. Simultaneously generalising these facts, we show that finite-dimensional CAT(0) cube complexes have Property A. We do not assume that the complex is locally finite. We also prove that given a discrete group acting properly on a finite-dimensional CAT(0) cube complex the stabilisers of vertices at infinity are amenable
Finite asymptotic dimension for CAT(0) cube complexes
No full textWe prove that the asymptotic dimension of a finite-dimensional CAT(0) cube complex is bounded above by the dimension. To achieve this we prove a controlled colouring theorem for the complex. We also show that every CAT(0) cube complex is a contractive retraction of an infinite dimensional cube. As an example of the dimension theorem we obtain bounds on the asymptotic dimension of small cancellation groups
Literary Studies : The Author Cat - Clemens's Life in Fiction
No full textA review of The Author Cat: Clemens's Life in Fiction by Forrest G. Robinson (Fordham UP, 2007).\ud
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Even at its most basic, guilt forms a counterweight to the hesitancy and unpleasantness of authorship, forcing writers back to the desk when they have come to despise their work. Guilt as task-master is familiar to most, even those to whom more elevated feelings, such as inspiration, make occasional visits. It seems that guilt is effective because writing is so seldom an organic or natural activity - rather, good writing emerges out of unhappy pressures that eventually overwhelm the writer's evasive strategies, from visits to the fridge door to the most sophisticated forms they take, such as when the author creates a narrative persona that claims to have owned up..
Muscle proteome changes during cancer
No full textINTRODUCTION. Both cancer and cancer associated therapies (CAT; including chemotherapy or concurrent chemoradiation) disrupt cellular metabolism throughout the body, including the regulation of skeletal muscle mass and function. Adjunct testosterone therapy during standard of care chemotherapy and chemoradiation modulates CAT-induced dysregulation of skeletal muscle metabolism and protects lean body mass during CAT. However, the extent to which the skeletal muscle proteome is altered under these therapeutic conditions is unknown.
OBJECTIVE. We probed the skeletal muscle proteome of cancer patients as an ancillary analysis following a randomized, double-blind, placebo-controlled phase II trial investigating the effect of adjunct testosterone on body composition in men and women with advanced cancers undergoing CAT.
METHODS. Men and women diagnosed with late stage (≥IIB) or recurrent head and neck or cervical cancer who were scheduled to receive standard of care CAT were administered an adjunct 7 week treatment of weekly intramuscular injections of either 100 mg testosterone (CAT+T, n = 9; 3M/6F) or placebo/saline (CAT+P, n = 10; 7 M/3F). Biopsies were performed on the vastus lateralis before (PRE) and after (POST) the 7 week treatment. Extracted proteins were separated with 2-dimensional gel electrophoresis (2DE), and subjected to analyses of total protein abundance, phosphorylation and s-nitrosylation. Proteoforms showing significant fold differences (t-test p ≤ 0.05) between PRE and POST timepoints were identified by mass spectroscopy (MS), and lists of altered proteins were subjected to Gene Set Enrichment Analysis (GSEA) to identify affected pathways.
RESULTS. A total of 756 distinct protein spots were identified. Of those spots, 102 were found to be altered in terms of abundance, phosphorylation, or s-nitrosylation, and identified by MS analysis to represent 59 unique proteins. Among the biological processes and pathways identified, CAT+P impacted muscle contraction, catabolic processes, and oxygen transport, while CAT+T impacted transcription regulation, muscle differentiation, muscle development, and contraction.
CONCLUSIONS. Cancer and CAT significantly altered the skeletal muscle proteome in a manner suggestive of loss of structural integrity, reduced contractile function, and disrupted metabolism. Proteomic analysis suggests that the addition of adjunct testosterone minimized the structural and contractile influence of cancer and its associated therapies
The Thursday Murder Club: Launching a megabrand author - a publishing case study
No full textIn 2020, the Christmas book charts in the UK made headlines: Barack Obama’s eagerly awaited autobiography, The Promised Land, was beaten to the top spot by The Thursday Murder Club by Richard Osman, a debut cosy crime novel set in a retirement village. Not only did Osman’s book beat the former US president’s expected bestseller, it also broke records, becoming the fastest-selling debut crime novel of all time. Although Osman has a certain level of fame in the UK from his TV appearances on shows such as Pointless, his celebrity status does not entirely explain the novel’s huge sales. This article tracks the acquisition, publication, and promotion journey of The Thursday Murder Club in order to understand the industry and cultural context of its success and to interrogate the role of celebrity in the creation of author brands. The findings suggest that the unexpected scale of the success of the book owed to a number of factors, including in-depth editing by the novel’s agent, editor, and author to tighten up the plot, an extensive and strategic promotional campaign, the pandemic (which drove interest in the book’s genre and themes), and the quality of the writing. We find that the book’s success was accentuated by Osman’s celebrity status rather than being entirely reliant on it. This research adds to the growing scholarship on celebrity authorship by means of an in-depth case study and provides insight into the processes behind publishing a ‘celebrity’ book and launching a megabrand author
Cat on a Hot Tin Roof Rehearsal
No full textA scene from the production of Cat on A Hot Tin Roof rehearsal at Wright State University.https://corescholar.libraries.wright.edu/wsu_historical_photos/1511/thumbnail.jp
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