8,215 research outputs found
Romantic Dialogues: Writing the Self in De Quincey and Woolf
No full textVirginia Woolf has been recognised as a pioneering modernist writer creating a new literary voice. It is not unusual to discover in Woolf’s writings the aesthetic and literary traces of those past traditions and influences which have been woven into her modern narratives. One significant, but often overlooked, influence comes from the Romantic period and the essayist, Thomas De Quincey. De Quincey’s stylish essays inspire Woolf’s art. Both writers’ fascination with representing the self (and their devotion to creating a literary thinking about, and narrative of, the subject) indicates a shared affinity between these two writers in spite of important cultural, historical, and social differences between them. My treatment of the self in De Quincey and Woolf is aware of the aesthetic and literary affinities between them and those cultural and historical differences that divide them. Tracing important connections between these two important writers sheds light on the larger concerns and patterns of both the literary scenes of Romanticism and Modernism.
Six chapters in three sections focus on three main aspects of the self central to De Quincey and Woolf—the art of literature, the representation of time and the question of autobiographical writing. Chapter One and Two investigate De Quincey’s literature of power and Woolf’s art of fiction to examine the relationship between literary representation and the self. Chapter Three and Four discuss issues of time and self in De Quincey and Woolf. The final two chapters contend that De Quincey’s and Woolf’s reflections on literary representation, and time as a philosophical problem are embodied in their writings of the self across their respective literary careers. A project of this kind is alert to and enriches a recent burgeoning critical interest from Romanticists and Modernists alike in the exchanges, interchanges, bequests, and legacies of Romanticism to Modernism
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Moral Good, the Beatific Vision, and God’s Kingdom Writings by Germain Grisez and Peter Ryan, S.J.. Edited by Peter J. Weigel
No full textFor close to half a century, the work of Germain Grisez has been highly influential, and his writings continue to receive considerable attention from philosophers and theologians of diverse viewpoints. His co-author for this work is the professor and noted moral theologian Fr. Peter Ryan, S.J., currently the executive director of the Secretariat of Doctrine and Canonical Affairs of the United States Conference of Catholic Bishops (USCCB). These two eminent scholars explore fundamental questions about Christian eschatology, moral theory, the purpose of human life, and the promise of human fulfilment. The authors examine Christian teaching on the final destiny of persons, investigating the meaning of God's kingdom, the hope of the beatific vision, and the centrality of moral goodness and divine grace in one's final end. This work is an ideal source for students, scholars, ministers and lay persons interested in basic questions of Christian theology, the philosophy of religion, ethical theory, and Catholic doctrin
The dialectic of self and other in Montaigne, Proust and Woolf
No full textThis thesis investigates the construction of identity in relation to an other. It considers three
writers who, working at moments when the nature of selfhood was an urgent issue, conduct
profound and original enquiries into the question of self- construction, and seeks both to
reassess their contributions to this debate, and, in bringing their preoccupations and methods
to bear upon each other, to open up new ways of approaching and reading their work.
Considering a range of socio-cultural and religious forms of otherness -- the cannibal, the
witch, the Jew, the aristocrat, the woman, the divine -- it embraces material from a number of
important modem critical fields, and suggests how these topics might be combined to offer a
coherent statement about the enduring issue of s elf- fashioning.
The thesis seeks to map out a trajectory of decreasing investment in external communities,
and an increasing perception of the self as a source and agent in the construction of identity.
Looking in turn at the work of Montaigne, Proust and Woolf, it argues that where the Essais
construct complex orders which appropriate the other to reinforce the identity of the self,
Proust and Woolf increasingly, although gradually, and by no means always successfully,
attempt to negotiate a less precisely- engaged relationship between other and self, and to
assign the other a less constitutive role in the realization and expression of identity. The
thesis also considers more briefly contexts in which this trajectory is reversed. To the extent
that they examine modernist subjectivity, Proust and Woolf articulate an anxiety about the
separation of self and world which leads to an attempted recuperation of the integrated orders
depicted by Montaigne
Portrait of Peter J. Jerry.
No full textHandwritten inscription: \u27With all good wishes - Peter J. Jerry\u27https://egrove.olemiss.edu/fmjohnston/1241/thumbnail.jp
Gesamtkunstwerk as an aesthetic pre-occupation in the novels of Virginia Woolf.
No full textPhDThis thesis aims to show that Wagner's theories of Gesamtkunstwerk were a
pre-occupation in Woolf's work throughout her career. The introduction
explores Gesamtkunstwerk theory, tracing its development in theories
concerning the combination of art forms, I go on to show how Woolf uses the
Voyage Out to explore what the modern novel can learn from musical arts, while
Jacob's Room adds painting to music as a significant field of interest for
Woolf Mrs Dalloway adds to the complexity of combination, for I will
demonstrate that in this novel a Nietzschean interpretation of Wagner's ideas
found in The Birth of Tragedy is detectable, allowing Woolf to compare the
motivation of more extreme avant-garde groups. The chapter on To the
Lighthouse will consider Woolf's evaluation of her parents' cultural
background and the influence of Roger Fry on her developing aesthetic theory
of combination. I shall argue that understanding of these areas allows Woolf to
begin to experiment with her own form of Gesamtkunstwerk. It is in The
Waves that the connection with Wagner is most obvious. Here, I believe
Woolf shifts the focus of attention from Wagnerian theories of
Gesamtkunstwerk to the Modernists' development of such ideas,
demonstrating her knowledge of Diaghilev's Ballets Russes. Looking closely
at the 1915 Raid Scene in The Years, I intend to show that Woolf's thinking on
the concept of combination is equally radical in this novel which is often
considered to be more conventional. I will go on to suggest that Between the
Acts, widely acknowledged to indicate a crisis in Woolf's confidence in
Modernism, marks a turning point in her thinking about the possibilities of
combining the arts to achieve Gesamtkunstwerk. I will argue that in this piece
Woolf provides us with all the elements used to create unity in the previous
works and yet they are never wholly united. Woolf, however, is not suggesting
that Gesamtkunstwerk is an impossibility, she is rather indicating that the
audience lacks the ability to provide the stage for such a piece to exist
A fuzzy logic approach to analyzing gene expression data
No full textWoolf, Peter J., and Yixin Wang. A fuzzy logic approach to analyzing gene expression data. Physiol Genomics 3: 9–15, 2000.—We have developed a novel algorithm for analyzing gene expression data. This algorithm uses fuzzy logic to transform expression values into qualitative descriptors that can be evaluated by using a set of heuristic rules. In our tests we designed a model to find triplets of activators, repressors, and targets in a yeast gene expression data set. For the conditions tested, the predictions made by the algorithm agree well with experimental data in the literature. The algorithm can also assist in determining the function of uncharacterized proteins and is able to detect a substantially larger number of transcription factors than could be found at random. This technology extends current techniques such as clustering in that it allows the user to generate a connected network of genes using only expression data.</jats:p
Joseph Bimeler letter to Peter Kaufmann, June 8, 1844
No full textLetter from J. M. Bimeler (by Christian Weibel) to Peter Kaufmann, acknowledging receipt of Bibles and spelling books and ordering more Bibles. He repeats his statement from his letter of April 31, 1844, of a preference for Bibles that embrace the Apocrypha. The letter also requests a catalog of books on hand at Kaufmann's establishment.
Led by Joseph Bimeler (sometimes spelled Bäumeler) in 1817, a group of Lutheran separatists left Germany and eventually established the small community of Zoar in Tuscarawas County, Ohio. The group formed the Society of Separatists of Zoar, in which each person donated his or her property to the community as a whole, and in exchange for their work, the society would provide for them. After decades of economic prosperity, the unity of the village declined, and by 1898 the Zoarites disbanded the society.
Peter Kaufmann was a German immigrant and intellectual. He arrived first in Philadelphia, Pennsylvania, in 1820; in 1826 he became professor of languages at the Harmony Society town of Economy, Pennsylvania. In 1827, Kaufmann led the establishment of Teutonia, a utopian community in Columbiana County, Ohio, and published its weekly titled "Teutonia: The Herald of a Better Time." Following this he moved to Canton, Ohio, where he became translator and editor of "Der Vaterlandsfreund und Geist der Zeit" under Solomon Sala. Additionally, Kaufmann wrote a number of books on education, as well as a German almanac. He was also an influential Democrat, counting President Van Buren among his friends, and knew Ralph Waldo Emerson
COMPUTATIONAL ANALYSIS OF G-PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION
No full textMechanistic models of G-protein coupled receptor (GPCR) signaling are used to gain insight into how changes in drug properties affect cellular response. Broadly, this work is divided in to three areas focusing on drug screening, desensitization, and receptor dimerization.
First, ordinary differential equation models are used to examine biases in drug screening assays such as those used in drug discovery. It is shown that some screens should be innately biased against detecting inverse agonists and as such may miss pharmaceutically valuable drug leads. However, the results also suggest ways in which the screening assay can be modified to correct this bias.
Second, Monte Carlo simulations of protein diffusion and reaction are used to determine the effects of drug properties on GPCR activation and desensitization. For most GPCRs, drugs cause an initial burst of activity (activation) followed by an attenuation of the signal over long times (desensitization). Simulations of this activation and desensitization process show that the mean drug-receptor lifetime can affect
desensitization in a way that allows receptor activation and desensitization to be partially decoupled.
Third, Monte Carlo simulations of receptor dimerization and diffusion are used to show how dimerization can affect membrane organization. Many membrane bound proteins, including GPCRs, form transient dimers, but the physiological reason for dimerization is not clear. The simulations show that dimerization under diffusion limited conditions can lead to the formation of extended clusters. These clusters, in turn, can alter the receptor internalization rate and the degree of cross-talk among receptors, in agreement with experimental findings.
Overall, this work has a variety of implications. Pharmacologically, this work presents a new way of making drug discovery a more rational process by focusing assays toward drugs with desirable efficacies and improved desensitization profiles. Similarly, receptor dimerization could also provide a novel mechanism for affecting drug signaling. For basic biology, the modeling work presented here suggests that dimerization could provide a new way to control protein organization within the cell membrane. Together this work helps us to provide us with a more mechanistic understanding of how cells communicate via GPCRs.http://deepblue.lib.umich.edu/bitstream/2027.42/133962/1/woolf.thesis.pdfDescription of woolf.thesis.pdf : Peter Woolf Thesis Documen
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